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Current Atherosclerosis Reports

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01-02-2018 | Evidence-Based Medicine (L. Roever, Section Editor)

Human Immunodeficiency Virus Infection, Antiretroviral Therapy, and Statin: a Clinical Update

Authors: Hugo Ribeiro Zanetti, Leonardo Roever, Alexandre Gonçalves, Elmiro Santos Resende

Published in: Current Atherosclerosis Reports | Issue 2/2018

Abstract

Purpose of Review

This clinical update is intended to focus in relationship between HIV infection and use of antiretroviral therapy (ART) and statin.

Recent Findings

Though ART significantly changed the course of HIV infection, it is related to numerous side effects principally to the lipid profile. In this way, statins became one of the most used lipid-lowering therapies in this population. In our clinical update, we evaluated studies that demonstrate the relationship and molecular mechanisms that HIV infection and ART use trigger dyslipidemia and also the use of statin to reduce this condition.

Summary

We have demonstrated that use of statin can be used in dyslipidemic HIV-infected people as long as there is no drug interaction with ART. Recently, studies using rosuvastatin have shown greater effects when compared to the other statins.

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Title: Human Immunodeficiency Virus Infection, Antiretroviral Therapy, and Statin: a Clinical Update
Authors: Hugo Ribeiro Zanetti
Leonardo Roever
Alexandre Gonçalves
Elmiro Santos Resende
Publication date: 01-02-2018
Publisher: Springer US
Published in: Current Atherosclerosis Reports / Issue 2/2018
Print ISSN: 1523-3804
Electronic ISSN: 1534-6242
DOI: https://doi.org/10.1007/s11883-018-0708-z

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Abstract

Purpose of Review

Recent Findings

Summary

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