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Current Atherosclerosis Reports
Published in: Current Atherosclerosis Reports 4/2012

01-08-2012 | Cardiovascular Disease and Stroke (M Fink and J Safdieh, Section Editors)

The Pathophysiology and Clinical Presentation of Cerebral Amyloid Angiopathy

Authors: Eitan Auriel, Steven Mark Greenberg

Published in: Current Atherosclerosis Reports | Issue 4/2012

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Abstract

Cerebral amyloid angiopathy (CAA) is defined as the deposition of amyloid ß peptide within leptomeningial and cortical vessels, likely reflecting an imbalance between Aβ production and clearance. Amyloid buildup triggers a series of destructive alterations in the cerebral vascular architecture, leading to a spectrum of neurological events including lobar intracerebral hemorrhage, brain ischemia and cognitive decline. Although traditionally diagnosed pathologically, neuroimaging has taken a central role in defining CAA. This review will discuss the pathological, clinical and radiological aspects of CAA.
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Metadata
Title
The Pathophysiology and Clinical Presentation of Cerebral Amyloid Angiopathy
Authors
Eitan Auriel
Steven Mark Greenberg
Publication date
01-08-2012
Publisher
Current Science Inc.
Published in
Current Atherosclerosis Reports / Issue 4/2012
Print ISSN: 1523-3804
Electronic ISSN: 1534-6242
DOI
https://doi.org/10.1007/s11883-012-0254-z

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