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Current Allergy and Asthma Reports

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01-04-2020 | Chlamydophila Pneumoniae | Asthma (V Ortega, Section Editor)

Th17/IL-17 Axis Regulated by Airway Microbes Get Involved in the Development of Asthma

Authors: Dan Liu, Yurong Tan, Ousman Bajinka, Lili Wang, Zhongxiang Tang

Published in: Current Allergy and Asthma Reports | Issue 4/2020

Abstract

Purpose of Review

Bronchial asthma is a common respiratory disease induced by immune imbalance, characterized by chronic non-specific airway inflammation and airway hyperresponsiveness (AHR). Many factors induce asthma, among which respiratory infection is the important cause. In this review, we discuss how respiratory microbes participate in the occurrence and progression of asthma via Th17/IL-17 axis.

Recent Findings

Pathogenesis of asthma has been considered as closely related to the imbalance in number and function of Th1/Th2 in the CD4⁺ T lymphocyte subsets. Recent studies have shown that Th17 cell and its secretory IL-17 also play an important role in AHR. Respiratory virus, bacteria, fungi, and other respiratory microbial infections can directly or indirectly induce the differentiation of Th17 cell and the production of related cytokines to induce AHR.

Summary

Respiratory microbial infection can affect the TH17/IL-17A axis through a variety of mechanisms, thereby promoting the occurrence and development of asthma, and these specific mechanisms may provide new effective therapeutic ideas for asthma.

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Title: Th17/IL-17 Axis Regulated by Airway Microbes Get Involved in the Development of Asthma
Authors: Dan Liu
Yurong Tan
Ousman Bajinka
Lili Wang
Zhongxiang Tang
Publication date: 01-04-2020
Publisher: Springer US
Keywords: Chlamydophila Pneumoniae
Bronchial Asthma
Cytokines
Published in: Current Allergy and Asthma Reports / Issue 4/2020
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-020-00903-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Th17/IL-17 Axis Regulated by Airway Microbes Get Involved in the Development of Asthma

Abstract

Purpose of Review

Recent Findings

Summary

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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