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Current Allergy and Asthma Reports

Published in:

01-05-2017 | Basic and Applied Science (I Lewkowich, Section Editor)

Mitochondrial Function in Allergic Disease

Authors: Divyaanka Iyer, Navya Mishra, Anurag Agrawal

Published in: Current Allergy and Asthma Reports | Issue 5/2017

Abstract

Purpose of the Review

The connections between allergy, asthma and metabolic syndrome are becoming increasingly clear. Recent research suggests a unifying mitochondrial link between the diverse phenotypes of these interlinked morbidities. The scope of this review is to highlight cellular mechanisms, epidemiology and environmental allergens influencing mitochondrial function and its importance in allergy and asthma. We briefly also consider the potential of mitochondria-targeted therapies in prevention and cure.

Recent Findings

Recent research has shown allergy, asthma and metabolic syndrome to be linked to mitochondrial dysfunction. Environmental pollutants and allergens are observed to cause mitochondrial dysfunction, primarily by inducing oxidative stress and ROS production. Malfunctioning mitochondria change the bioenergetics of the cell and its metabolic profile to favour systemic inflammation, which drives all three types of morbidities.

Summary

Given the existing experimental evidence, approaches targeting mitochondria (e.g. antioxidant therapy and mitochondrial replacement) are being conducted in relevant disease models—with some progressing towards clinical trials, making mitochondrial function the focus of translational therapy research in asthma, allergy and linked metabolic syndrome.

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Title: Mitochondrial Function in Allergic Disease
Authors: Divyaanka Iyer
Navya Mishra
Anurag Agrawal
Publication date: 01-05-2017
Publisher: Springer US
Published in: Current Allergy and Asthma Reports / Issue 5/2017
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-017-0695-0

At a glance: The STEP trials

Springer Medicine

Mitochondrial Function in Allergic Disease

Abstract

Purpose of the Review

Recent Findings

Summary

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose of the Review

Recent Findings

Summary

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