Skip to main content
Top
Published in: Current Allergy and Asthma Reports 5/2017

01-05-2017 | Immunologic/Diagnostic Tests in Allergy (M Chapman and A Pomés, Section Editors)

New Perspectives on the Diagnosis of Allergy to Anisakis spp.

Authors: Ignacio Moneo, Noelia Carballeda-Sangiao, Miguel González-Muñoz

Published in: Current Allergy and Asthma Reports | Issue 5/2017

Login to get access

Abstract

Purpose of Review

To compare the prevalence of sensitization in different countries based on specific IgE values and to evaluate the use of isolated native or recombinant allergens for diagnosis.

Recent Findings

Isolated allergens help in the diagnosis of truly sensitized patients avoiding false positives due to cross-reactions. Their use is therefore highly recommended, especially when used as a combination of several relevant allergens.

Summary

The use of purified allergens allows an accurate diagnosis and this has led to three important findings: (1) in addition to the digestive route of sensitization, occupational and non-digestive exposure seems to be clinically relevant. (2) The parasite appears as an important agent for chronic urticaria. And (3) in endemic countries, the amount of highly sensitized subjects in the general population could be as high as 7%. Adequate information to asymptomatic patients on fish consumption habits would avoid new contacts with parasite allergens and decrease their specific IgE levels and consequently the appearance of acute or chronic episodes induced by the parasite.
Literature
1.
go back to reference van Thiel PH, van Houten H. The herring worm Anisakis marina as a human parasite outside the wall of the gastrointestinal tract. Ned Tijdschr Geneeskd. 1966;110(35):1524–8.PubMed van Thiel PH, van Houten H. The herring worm Anisakis marina as a human parasite outside the wall of the gastrointestinal tract. Ned Tijdschr Geneeskd. 1966;110(35):1524–8.PubMed
2.
go back to reference EFSA Panel on Biological Hazards (BIOHAZ). Scientific opinion on risk assessment of parasites in fishery products. EFSA J. 2010;8:1543. 91 pp CrossRef EFSA Panel on Biological Hazards (BIOHAZ). Scientific opinion on risk assessment of parasites in fishery products. EFSA J. 2010;8:1543. 91 pp CrossRef
8.
go back to reference Daschner A, Pascual CY. Anisakis simplex: sensitization and clinical allergy. Curr Opin Allergy Clin Immunol. 2005;5(3):281–5.CrossRefPubMed Daschner A, Pascual CY. Anisakis simplex: sensitization and clinical allergy. Curr Opin Allergy Clin Immunol. 2005;5(3):281–5.CrossRefPubMed
9.
go back to reference Arcos SC, Ciordia S, Roberston L, Zapico I, Jiménez-Ruiz Y, Gonzalez-Muñoz M, et al. Proteomic profiling and characterization of differential allergens in the nematodes Anisakis simplex sensu stricto and A. pegreffii. Proteomics. 2014;14(12):1547–68. doi:10.1002/pmic.201300529.CrossRefPubMed Arcos SC, Ciordia S, Roberston L, Zapico I, Jiménez-Ruiz Y, Gonzalez-Muñoz M, et al. Proteomic profiling and characterization of differential allergens in the nematodes Anisakis simplex sensu stricto and A. pegreffii. Proteomics. 2014;14(12):1547–68. doi:10.​1002/​pmic.​201300529.CrossRefPubMed
12.
go back to reference Patelis A, Janson C, Borres MP, Nordvall L, Alving K, Malinovschi A. Aeroallergen and food IgE sensitization and local and systemic inflammation in asthma. Allergy. 2014;69(3):380–7. doi:10.1111/all.12345.CrossRefPubMed Patelis A, Janson C, Borres MP, Nordvall L, Alving K, Malinovschi A. Aeroallergen and food IgE sensitization and local and systemic inflammation in asthma. Allergy. 2014;69(3):380–7. doi:10.​1111/​all.​12345.CrossRefPubMed
13.
go back to reference Caffarelli C, Garrubba M, Greco C, Mastrorilli C, Povesi DC. Asthma and food allergy in children: is there a connection or interaction? Front Pediatr. 2016;5(4):34. doi:10.3389/fped.2016.00034. Caffarelli C, Garrubba M, Greco C, Mastrorilli C, Povesi DC. Asthma and food allergy in children: is there a connection or interaction? Front Pediatr. 2016;5(4):34. doi:10.​3389/​fped.​2016.​00034.
14.
go back to reference Scala E, Giani M, Pirrotta L, Guerra EC, Cadoni S, Girardelli CR, et al. Occupational generalised urticaria and allergic airborne asthma due to Anisakis simplex. Eur J Dermatol. 2001;11(3):249–50.PubMed Scala E, Giani M, Pirrotta L, Guerra EC, Cadoni S, Girardelli CR, et al. Occupational generalised urticaria and allergic airborne asthma due to Anisakis simplex. Eur J Dermatol. 2001;11(3):249–50.PubMed
16.
18.
go back to reference •• Mladineo I, Poljak V, Martínez-Sernández V, Ubeira FM. Anti-Anisakis IgE seroprevalence in the healthy Croatian coastal population and associated risk factors. PLoS Negl Trop Dis. 2014;8(2):e2673. doi:10.1371/journal.pntd.0002673. Analysis of IgE seroprevalence to Anisakis spp. in healthy population. A logistic univariate regression analysis confirmed that raw fish intake, daily fish intake, homemade origin of fish dish and occupational exposure were risk factors associated to Anisakis spp. sensitization. CrossRefPubMedPubMedCentral •• Mladineo I, Poljak V, Martínez-Sernández V, Ubeira FM. Anti-Anisakis IgE seroprevalence in the healthy Croatian coastal population and associated risk factors. PLoS Negl Trop Dis. 2014;8(2):e2673. doi:10.​1371/​journal.​pntd.​0002673. Analysis of IgE seroprevalence to Anisakis spp. in healthy population. A logistic univariate regression analysis confirmed that raw fish intake, daily fish intake, homemade origin of fish dish and occupational exposure were risk factors associated to Anisakis spp. sensitization. CrossRefPubMedPubMedCentral
20.
go back to reference •• Barbarroja-Escudero J, Sanchez-Gonzalez MJ, Antolin-Amerigo D, Rodriguez-Rodriguez M, Alvarez-Mon M. Nonoccupational airborne-induced anaphylaxis caused by Anisakis simplex. J Investig Allergol Clin Immunol. 2016;26(3):196–7. doi:10.18176/jiaci.0055. The first report of non-occupational airborne-induced anaphylaxis caused by Anisakis established by a specific inhalation challenge. CrossRefPubMed •• Barbarroja-Escudero J, Sanchez-Gonzalez MJ, Antolin-Amerigo D, Rodriguez-Rodriguez M, Alvarez-Mon M. Nonoccupational airborne-induced anaphylaxis caused by Anisakis simplex. J Investig Allergol Clin Immunol. 2016;26(3):196–7. doi:10.​18176/​jiaci.​0055. The first report of non-occupational airborne-induced anaphylaxis caused by Anisakis established by a specific inhalation challenge. CrossRefPubMed
23.
25.
go back to reference Alonso-Gómez A, Moreno-Ancillo A, López-Serrano MC, Suarez-de-Parga JM, Daschner A, Caballero MT, et al. Anisakis simplex only provokes allergic symptoms when the worm parasitises the gastrointestinal tract. Parasitol Res. 2004;93(5):378–84. doi:10.1007/s00436-004-1085-9.CrossRefPubMed Alonso-Gómez A, Moreno-Ancillo A, López-Serrano MC, Suarez-de-Parga JM, Daschner A, Caballero MT, et al. Anisakis simplex only provokes allergic symptoms when the worm parasitises the gastrointestinal tract. Parasitol Res. 2004;93(5):378–84. doi:10.​1007/​s00436-004-1085-9.CrossRefPubMed
26.
go back to reference Peñalver J, Dolores EM, Muñoz P. Absence of anisakid larvae in farmed European sea bass (Dicentrarchus labrax L.) and gilthead sea bream (Sparus aurata L.) in Southeast Spain. J Food Prot. 2010;73:1332–4.CrossRefPubMed Peñalver J, Dolores EM, Muñoz P. Absence of anisakid larvae in farmed European sea bass (Dicentrarchus labrax L.) and gilthead sea bream (Sparus aurata L.) in Southeast Spain. J Food Prot. 2010;73:1332–4.CrossRefPubMed
27.
go back to reference Trujillo MJ, Rodríguez A, Gracia Bara MT, Matheu V, Herrero T, Rubio M, et al. Dietary recommendations for patients allergic to Anisakis simplex. Allergol Immunopathol (Madr). 2002;30:311–4.CrossRef Trujillo MJ, Rodríguez A, Gracia Bara MT, Matheu V, Herrero T, Rubio M, et al. Dietary recommendations for patients allergic to Anisakis simplex. Allergol Immunopathol (Madr). 2002;30:311–4.CrossRef
29.
go back to reference Polimeno L, Loiacono M, Pesetti B, Mallamaci R, Mastrodonato M, Azzarone A, et al. Anisakiasis, an underestimated infection: effect on intestinal permeability of Anisakis simplex-sensitized patients. Foodborne Pathog Dis. 2010;7(7):809–14. doi:10.1089/fpd.2009.0484.CrossRefPubMed Polimeno L, Loiacono M, Pesetti B, Mallamaci R, Mastrodonato M, Azzarone A, et al. Anisakiasis, an underestimated infection: effect on intestinal permeability of Anisakis simplex-sensitized patients. Foodborne Pathog Dis. 2010;7(7):809–14. doi:10.​1089/​fpd.​2009.​0484.CrossRefPubMed
33.
go back to reference • Fitzsimmons CM, Falcone FH, Dunne DW. Helminth allergens, parasite-specific IgE, and its protective role in human immunity. Front Immunol. 2014;14(5):61. doi:10.3389/fimmu.2014.00061. This review describes the modulation of the human immune responses by helminth parasites and compares dominant IgE-antigens in worms with clinically important environmental allergens. • Fitzsimmons CM, Falcone FH, Dunne DW. Helminth allergens, parasite-specific IgE, and its protective role in human immunity. Front Immunol. 2014;14(5):61. doi:10.​3389/​fimmu.​2014.​00061. This review describes the modulation of the human immune responses by helminth parasites and compares dominant IgE-antigens in worms with clinically important environmental allergens.
34.
go back to reference Pérez-Pérez J, Fernández-Caldas E, Marañón F, Sastre J, Bernal ML, Rodríguez J, et al. Molecular cloning of paramyosin, a new allergen of Anisakis simplex. Int Arch Allergy Immunol. 2000;123(2):120–9. doi:10.1159/000024442.CrossRefPubMed Pérez-Pérez J, Fernández-Caldas E, Marañón F, Sastre J, Bernal ML, Rodríguez J, et al. Molecular cloning of paramyosin, a new allergen of Anisakis simplex. Int Arch Allergy Immunol. 2000;123(2):120–9. doi:10.​1159/​000024442.CrossRefPubMed
36.
go back to reference Rodriguez-Mahillo AI, Gonzalez-Muñoz M, Gomez-Aguado F, Rodriguez-Perez R, Corcuera MT, Caballero ML, et al. Cloning and characterisation of the Anisakis simplex allergen Ani s 4 as a cysteine-protease inhibitor. Int J Parasitol. 2007;37(8–9):907–17. doi:10.1016/j.ijpara.2007.01.007.CrossRefPubMed Rodriguez-Mahillo AI, Gonzalez-Muñoz M, Gomez-Aguado F, Rodriguez-Perez R, Corcuera MT, Caballero ML, et al. Cloning and characterisation of the Anisakis simplex allergen Ani s 4 as a cysteine-protease inhibitor. Int J Parasitol. 2007;37(8–9):907–17. doi:10.​1016/​j.​ijpara.​2007.​01.​007.CrossRefPubMed
41.
44.
go back to reference Moneo I, Caballero ML, Rodriguez-Perez R, Rodriguez-Mahillo AI, Gonzalez-Muñoz M. Sensitization to the fish parasite Anisakis simplex: clinical and laboratory aspects. Parasitol Res. 2007;101(4):1051–5. doi:10.1007/s00436-007-0587-7.CrossRefPubMed Moneo I, Caballero ML, Rodriguez-Perez R, Rodriguez-Mahillo AI, Gonzalez-Muñoz M. Sensitization to the fish parasite Anisakis simplex: clinical and laboratory aspects. Parasitol Res. 2007;101(4):1051–5. doi:10.​1007/​s00436-007-0587-7.CrossRefPubMed
45.
go back to reference Rodero M, Cuéllar C, Chivato T, Mateos JM, Laguna R. Western blot antibody determination in sera from patients diagnosed with Anisakis sensitization with different antigenic fractions of Anisakis simplex purified by affinity chromatography. J Helminthol. 2007;81(3):307–10. doi:10.1017/S0022149X07820220.CrossRefPubMed Rodero M, Cuéllar C, Chivato T, Mateos JM, Laguna R. Western blot antibody determination in sera from patients diagnosed with Anisakis sensitization with different antigenic fractions of Anisakis simplex purified by affinity chromatography. J Helminthol. 2007;81(3):307–10. doi:10.​1017/​S0022149X0782022​0.CrossRefPubMed
48.
go back to reference Ibarrola I, Arilla MC, Herrero MD, Esteban MI, Martínez A, Asturias JA. Expression of a recombinant protein immunochemically equivalent to the major Anisakis simplex allergen Ani s 1. J Investig Allergol Clin Immunol. 2008;18:78–83.PubMed Ibarrola I, Arilla MC, Herrero MD, Esteban MI, Martínez A, Asturias JA. Expression of a recombinant protein immunochemically equivalent to the major Anisakis simplex allergen Ani s 1. J Investig Allergol Clin Immunol. 2008;18:78–83.PubMed
53.
go back to reference Anadón AM, Rodríguez E, Gárate MT, Cuéllar C, Romarís F, Chivato T, et al. Diagnosing human anisakiasis: recombinant Ani s 1 and Ani s 7 allergens versus the UniCAP 100 fluorescence enzyme immunoassay. Clin Vaccine Immunol. 2010;17:496–502. doi:10.1128/CVI.00443-09.CrossRefPubMedPubMedCentral Anadón AM, Rodríguez E, Gárate MT, Cuéllar C, Romarís F, Chivato T, et al. Diagnosing human anisakiasis: recombinant Ani s 1 and Ani s 7 allergens versus the UniCAP 100 fluorescence enzyme immunoassay. Clin Vaccine Immunol. 2010;17:496–502. doi:10.​1128/​CVI.​00443-09.CrossRefPubMedPubMedCentral
54.
go back to reference Martínez-Aranguren RM, Gamboa PM, García-Lirio E, Asturias J, Goikoetxea MJ, Sanz ML. In vivo and in vitro testing with rAni s 1 can facilitate diagnosis of Anisakis simplex allergy. J Investig Allergol Clin Immunol. 2014;24(6):431–8.PubMed Martínez-Aranguren RM, Gamboa PM, García-Lirio E, Asturias J, Goikoetxea MJ, Sanz ML. In vivo and in vitro testing with rAni s 1 can facilitate diagnosis of Anisakis simplex allergy. J Investig Allergol Clin Immunol. 2014;24(6):431–8.PubMed
55.
go back to reference Lin AH, Nepstad I, Florvaag E, Egaas E, Van Do T. An extended study of seroprevalence of anti-Anisakis simplex IgE antibodies in Norwegian blood donors. Scand J Immunol. 2014;79(1):61–7. doi:10.1111/sji.12130.CrossRefPubMed Lin AH, Nepstad I, Florvaag E, Egaas E, Van Do T. An extended study of seroprevalence of anti-Anisakis simplex IgE antibodies in Norwegian blood donors. Scand J Immunol. 2014;79(1):61–7. doi:10.​1111/​sji.​12130.CrossRefPubMed
56.
go back to reference Iijima S, Moriyama T, Ichikawa H, Kobayashi Y, Shiomi K. A case of an allergic reaction due to Anisakis simplex possibly after the ingestion of squid—successful detection of four A. simplex allergens, Ani s 1, Ani s 2, Ani s 12 and troponin C-like protein. Arerugi. 2012;61(8):1104–10.PubMed Iijima S, Moriyama T, Ichikawa H, Kobayashi Y, Shiomi K. A case of an allergic reaction due to Anisakis simplex possibly after the ingestion of squid—successful detection of four A. simplex allergens, Ani s 1, Ani s 2, Ani s 12 and troponin C-like protein. Arerugi. 2012;61(8):1104–10.PubMed
57.
go back to reference Caballero ML, Umpierrez A, Perez-Piñar T, Moneo I, de Burgos C, Asturias JA, et al. Anisakis simplex recombinant allergens increase diagnosis specificity preserving high sensitivity. Int Arch Allergy Immunol. 2012;158(3):232–40. doi:10.1159/000331581.CrossRefPubMed Caballero ML, Umpierrez A, Perez-Piñar T, Moneo I, de Burgos C, Asturias JA, et al. Anisakis simplex recombinant allergens increase diagnosis specificity preserving high sensitivity. Int Arch Allergy Immunol. 2012;158(3):232–40. doi:10.​1159/​000331581.CrossRefPubMed
58.
go back to reference Carballeda-Sangiao N, Rodríguez-Mahillo AI, Careche M, Navas A, Caballero T, Dominguez-Ortega J, et al. Ani s 11-like protein is a pepsin-and heat-resistant major allergen of Anisakis spp. and a valuable tool for Anisakis allergy component-resolved diagnosis. Int Arch Allergy Immunol. 2016;169(2):108–12. doi:10.1159/000444981.CrossRefPubMed Carballeda-Sangiao N, Rodríguez-Mahillo AI, Careche M, Navas A, Caballero T, Dominguez-Ortega J, et al. Ani s 11-like protein is a pepsin-and heat-resistant major allergen of Anisakis spp. and a valuable tool for Anisakis allergy component-resolved diagnosis. Int Arch Allergy Immunol. 2016;169(2):108–12. doi:10.​1159/​000444981.CrossRefPubMed
59.
go back to reference Gamboa PM, Asturias J, Martínez R, Antépara I, Jáuregui I, Urrutia I, et al. Diagnostic utility of components in allergy to Anisakis simplex. J Investig Allergol Clin Immunol. 2012;22:13–9.PubMed Gamboa PM, Asturias J, Martínez R, Antépara I, Jáuregui I, Urrutia I, et al. Diagnostic utility of components in allergy to Anisakis simplex. J Investig Allergol Clin Immunol. 2012;22:13–9.PubMed
61.
go back to reference Cuéllar C, Daschner A, Valls A, De Frutos C, Fernández-Fígares V, Anadón AM, et al. Ani s 1 and Ani s 7 recombinant allergens are able to differentiate distinct Anisakis simplex-associated allergic clinical disorders. Arch Dermatol Res. 2012;304(4):283–8. doi:10.1007/s00403-012-1206-8.CrossRefPubMed Cuéllar C, Daschner A, Valls A, De Frutos C, Fernández-Fígares V, Anadón AM, et al. Ani s 1 and Ani s 7 recombinant allergens are able to differentiate distinct Anisakis simplex-associated allergic clinical disorders. Arch Dermatol Res. 2012;304(4):283–8. doi:10.​1007/​s00403-012-1206-8.CrossRefPubMed
62.
go back to reference Daschner A, Fernández-Fígares V, Rodero M, Valls A, De Frutos C, Ubeira FM, et al. Specific IgG4: possible role in the pathogenesis and a new marker in the diagnosis of Anisakis-associated allergic disease. Scand J Immunol. 2014;79(2):120–6. doi:10.1111/sji.12129.CrossRefPubMed Daschner A, Fernández-Fígares V, Rodero M, Valls A, De Frutos C, Ubeira FM, et al. Specific IgG4: possible role in the pathogenesis and a new marker in the diagnosis of Anisakis-associated allergic disease. Scand J Immunol. 2014;79(2):120–6. doi:10.​1111/​sji.​12129.CrossRefPubMed
63.
go back to reference López-Sáez MP, Zubeldia JM, Caloto M, Olalde S, Pelta R, et al. Is Anisakis simplex responsible for chronic urticaria? Allergy Asthma Proc. 2003;24(5):339–45.PubMed López-Sáez MP, Zubeldia JM, Caloto M, Olalde S, Pelta R, et al. Is Anisakis simplex responsible for chronic urticaria? Allergy Asthma Proc. 2003;24(5):339–45.PubMed
64.
go back to reference Fernández-Fígares V, Rodero M, Valls A, De Frutos C, Daschner A, Cuéllar C. Positive associations between infections of Toxoplasma gondii and seropositivity with Anisakis simplex in human patients suffering from chronic urticaria. J Helminthol. 2015;89(6):707–13. doi:10.1017/S0022149X14000480.CrossRefPubMed Fernández-Fígares V, Rodero M, Valls A, De Frutos C, Daschner A, Cuéllar C. Positive associations between infections of Toxoplasma gondii and seropositivity with Anisakis simplex in human patients suffering from chronic urticaria. J Helminthol. 2015;89(6):707–13. doi:10.​1017/​S0022149X1400048​0.CrossRefPubMed
65.
go back to reference Daschner A, Vega de la Osada F, Pascual CY. Allergy and parasites reevaluated: wide-scale induction of chronic urticaria by the ubiquitous fish-nematode Anisakis simplex in an endemic region. Allergol Immunopathol (Madr). 2005;33:31–7.CrossRef Daschner A, Vega de la Osada F, Pascual CY. Allergy and parasites reevaluated: wide-scale induction of chronic urticaria by the ubiquitous fish-nematode Anisakis simplex in an endemic region. Allergol Immunopathol (Madr). 2005;33:31–7.CrossRef
66.
go back to reference Frezzolini A, Cadoni S, De Pitá O. Usefulness of the CD63 basophil activation test in detecting Anisakis hypersensivity in patients with chronic urticaria: diagnosis and follow-up. Clin Exp Dermatol. 2010;35:765–70. doi:10.1111/j.1365-2230.2009.03694.x. Frezzolini A, Cadoni S, De Pitá O. Usefulness of the CD63 basophil activation test in detecting Anisakis hypersensivity in patients with chronic urticaria: diagnosis and follow-up. Clin Exp Dermatol. 2010;35:765–70. doi:10.​1111/​j.​1365-2230.​2009.​03694.​x.
67.
go back to reference • Ventura MT, Napolitano S, Menga R, Cecere R, Asero R. Anisakis simplex hypersensitivity is associated with chronic urticaria in endemic areas. Int Arch Allergy Immunol. 2013;160(3):297–300. doi:10.1159/000339869. Analysis of the association of chronic urticaria with Anisakis spp. sensitization in Italy and the beneficial effect of a 6-month diet regimen. CrossRefPubMed • Ventura MT, Napolitano S, Menga R, Cecere R, Asero R. Anisakis simplex hypersensitivity is associated with chronic urticaria in endemic areas. Int Arch Allergy Immunol. 2013;160(3):297–300. doi:10.​1159/​000339869. Analysis of the association of chronic urticaria with Anisakis spp. sensitization in Italy and the beneficial effect of a 6-month diet regimen. CrossRefPubMed
68.
go back to reference del Pozo MD. Estudio de la sensibilización a Anisakis simplex y su relevancia clínica como causa de urticaria o angioedema. 1998. Ph.D. thesis. University of Zaragoza, Spain. del Pozo MD. Estudio de la sensibilización a Anisakis simplex y su relevancia clínica como causa de urticaria o angioedema. 1998. Ph.D. thesis. University of Zaragoza, Spain.
69.
go back to reference Lopez-Saez MP, Zubeldia JM, Matheu V, Gracia MT, De Barrio M, Tornero P, et al. Sensibilización al Anisakis simplex: prevalencia en una consulta de Alergia hospitalaria de Madrid. Rev Esp Alergol Inmunol Clin. 1999;14:23–9. Lopez-Saez MP, Zubeldia JM, Matheu V, Gracia MT, De Barrio M, Tornero P, et al. Sensibilización al Anisakis simplex: prevalencia en una consulta de Alergia hospitalaria de Madrid. Rev Esp Alergol Inmunol Clin. 1999;14:23–9.
72.
go back to reference Abattouy N, Valero A, Martín-Sánchez J, Peñalver MC, Lozano J. Sensitization to Anisakis simplex species in the population of northern Morocco. J Investig Allergol Clin Immunol. 2012;22(7):514–9.PubMed Abattouy N, Valero A, Martín-Sánchez J, Peñalver MC, Lozano J. Sensitization to Anisakis simplex species in the population of northern Morocco. J Investig Allergol Clin Immunol. 2012;22(7):514–9.PubMed
73.
go back to reference • Carballeda-Sangiao N, Rodríguez-Mahillo AI, Puente S, Gutiérrez MT, Moneo I, González-Muñoz M. Anisakis/Ascaris IgE ratio improves specificity for the diagnosis of Anisakis simplex sensitization in travellers and immigrants. Acta Trop. 2014;138:1–4. doi:10.1016/j.actatropica.2014.05.020. ROC curve analysis providing cut-off values for the specific IgE to Anisakis spp. that increase the specificity of routine tests. CrossRefPubMed • Carballeda-Sangiao N, Rodríguez-Mahillo AI, Puente S, Gutiérrez MT, Moneo I, González-Muñoz M. Anisakis/Ascaris IgE ratio improves specificity for the diagnosis of Anisakis simplex sensitization in travellers and immigrants. Acta Trop. 2014;138:1–4. doi:10.​1016/​j.​actatropica.​2014.​05.​020. ROC curve analysis providing cut-off values for the specific IgE to Anisakis spp. that increase the specificity of routine tests. CrossRefPubMed
74.
go back to reference Rodero I, García L, Moneo I, Caballero ML, Sanz JC, Ordobás M, et al. Seroprevalencia frente a Anisakis simplex en población adulta de la Comunidad de Madrid. Gac Sant. 2005;19(Supl 1):49. Rodero I, García L, Moneo I, Caballero ML, Sanz JC, Ordobás M, et al. Seroprevalencia frente a Anisakis simplex en población adulta de la Comunidad de Madrid. Gac Sant. 2005;19(Supl 1):49.
76.
go back to reference •• Bao M, Pierce GJ, Pascual S, González-Muñoz M, Mattiucci S, Mladineo I, et al. Assessing the risk of an emerging zoonosis of worldwide concern: anisakiasis. Sci Rep. 2017;7:43699. doi:10.1038/srep43699. Development of a quantitative risk assessment for predicting the number of annual anisakiasis cases in Spain. It was elaborated using data on fishery landings, fish infection rates and consumption habits from questionnaires. CrossRefPubMedPubMedCentral •• Bao M, Pierce GJ, Pascual S, González-Muñoz M, Mattiucci S, Mladineo I, et al. Assessing the risk of an emerging zoonosis of worldwide concern: anisakiasis. Sci Rep. 2017;7:43699. doi:10.​1038/​srep43699. Development of a quantitative risk assessment for predicting the number of annual anisakiasis cases in Spain. It was elaborated using data on fishery landings, fish infection rates and consumption habits from questionnaires. CrossRefPubMedPubMedCentral
77.
go back to reference Mattiucci S, D’Amelio S. Anisakiasis. In: Bruschi F, editor. Helminth infections and their impact on global public health. Springer; 2014. Mattiucci S, D’Amelio S. Anisakiasis. In: Bruschi F, editor. Helminth infections and their impact on global public health. Springer; 2014.
Metadata
Title
New Perspectives on the Diagnosis of Allergy to Anisakis spp.
Authors
Ignacio Moneo
Noelia Carballeda-Sangiao
Miguel González-Muñoz
Publication date
01-05-2017
Publisher
Springer US
Published in
Current Allergy and Asthma Reports / Issue 5/2017
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-017-0698-x

Other articles of this Issue 5/2017

Current Allergy and Asthma Reports 5/2017 Go to the issue

Pediatric Allergy and Immunology (W Dolen, Section Editor)

Chronic Candidiasis in Children

Basic and Applied Science (I Lewkowich, Section Editor)

Mitochondrial Function in Allergic Disease

Immunologic/Diagnostic Tests in Allergy (M Chapman and A Pomés, Section Editors)

Natural Evolution of IgE Responses to Mite Allergens and Relationship to Progression of Allergic Disease: a Review

Pediatric Allergy and Immunology (W Dolen, Section Editor)

Emerging Approaches to Food Desensitization in Children