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Published in:

01-05-2014 | RHINITIS (JJ OPPENHEIMER AND J CORREN, SECTION EDITORS)

Cytokine Profiles in Allergic Rhinitis

Author: Guy Scadding

Published in: Current Allergy and Asthma Reports | Issue 5/2014

Abstract

Allergic rhinitis, particularly seasonal allergic rhinitis, is considered a classic Th2-mediated disease, with important contributions to pathology by interleukins 4, 5 and 13. As such, allergic rhinitis is an excellent model for studying allergic inflammation, with findings potentially relevant to the mechanism of lower airways inflammation seen in allergic asthma. However, recent evidence has revealed roles for additional non-Th2 cytokines in asthma, including IL-17 family cytokines and epithelial-derived cytokines. Additionally, putative roles for epithelial-derived cytokines and innate lymphoid cells have been described in chronic rhinosinusitis with nasal polyps. Here, evidence for the involvement of different cytokines and cytokine groups in allergic rhinitis is considered.

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Title: Cytokine Profiles in Allergic Rhinitis
Author: Guy Scadding
Publication date: 01-05-2014
Publisher: Springer US
Published in: Current Allergy and Asthma Reports / Issue 5/2014
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-014-0435-7

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