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Published in: Current Allergy and Asthma Reports 6/2012

01-12-2012 | Pediatric Allergy and Immunology (JM Portnoy and CE Ciaccio, Section Editors)

IgE-Mediated Cow’s Milk Allergy in Children

Authors: Faith Huang, Jennifer S. Kim

Published in: Current Allergy and Asthma Reports | Issue 6/2012

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Abstract

The age at which the majority of children outgrow cow’s milk allergy now appears to be later than previously reported. Recent studies have attempted to elucidate factors that may help prevent cow’s milk allergy, assess markers of persistence, and evaluate the usefulness of new diagnostic methods. Strict avoidance of cow’s milk has been the mainstay of treatment. However, given the potential nutritional, social, and immunologic ramifications of cow’s milk elimination from a child’s diet, there has been a focus on reevaluating this therapeutic approach.
Literature
1.
go back to reference Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E, et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol. 2007;120(3):638–46. Epub 2007/07/14.PubMedCrossRef Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E, et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol. 2007;120(3):638–46. Epub 2007/07/14.PubMedCrossRef
2.
go back to reference Heine RG, Elsayed S, Hosking CS, Hill DJ. Cow's milk allergy in infancy. Curr Opin Allergy Clin Immunol. 2002;2(3):217–25. Epub 2002/06/05.PubMedCrossRef Heine RG, Elsayed S, Hosking CS, Hill DJ. Cow's milk allergy in infancy. Curr Opin Allergy Clin Immunol. 2002;2(3):217–25. Epub 2002/06/05.PubMedCrossRef
3.
go back to reference Host A. Cow's milk protein allergy and intolerance in infancy. Some clinical, epidemiological and immunological aspects. Pediatr Allergy Immunol: Off Publ Eur Soc Pediatr Allergy Immunol. 1994;5(5 Suppl):1–36. Epub 1994/01/01. Host A. Cow's milk protein allergy and intolerance in infancy. Some clinical, epidemiological and immunological aspects. Pediatr Allergy Immunol: Off Publ Eur Soc Pediatr Allergy Immunol. 1994;5(5 Suppl):1–36. Epub 1994/01/01.
4.
go back to reference Jarvinen KM, Chatchatee P. Mammalian milk allergy: clinical suspicion, cross-reactivities and diagnosis. Curr Opin Allergy Clin Immunol. 2009;9(3):251–8. Epub 2009/05/05.PubMedCrossRef Jarvinen KM, Chatchatee P. Mammalian milk allergy: clinical suspicion, cross-reactivities and diagnosis. Curr Opin Allergy Clin Immunol. 2009;9(3):251–8. Epub 2009/05/05.PubMedCrossRef
5.
go back to reference Host A, Halken S. A prospective study of cow milk allergy in Danish infants during the first 3 years of life. Clinical course in relation to clinical and immunological type of hypersensitivity reaction. Allergy. 1990;45(8):587–96. Epub 1990/11/01.PubMedCrossRef Host A, Halken S. A prospective study of cow milk allergy in Danish infants during the first 3 years of life. Clinical course in relation to clinical and immunological type of hypersensitivity reaction. Allergy. 1990;45(8):587–96. Epub 1990/11/01.PubMedCrossRef
6.
go back to reference Saarinen KM, Juntunen-Backman K, Jarvenpaa AL, Kuitunen P, Lope L, Renlund M, et al. Supplementary feeding in maternity hospitals and the risk of cow's milk allergy: a prospective study of 6209 infants. J Allergy Clin Immunol. 1999;104(2 Pt 1):457–61. Epub 1999/08/19.PubMedCrossRef Saarinen KM, Juntunen-Backman K, Jarvenpaa AL, Kuitunen P, Lope L, Renlund M, et al. Supplementary feeding in maternity hospitals and the risk of cow's milk allergy: a prospective study of 6209 infants. J Allergy Clin Immunol. 1999;104(2 Pt 1):457–61. Epub 1999/08/19.PubMedCrossRef
7.
go back to reference Schrander JJ, van den Bogart JP, Forget PP, Schrander-Stumpel CT, Kuijten RH, Kester AD. Cow's milk protein intolerance in infants under 1 year of age: a prospective epidemiological study. Eur J Pediatr. 1993;152(8):640–4. Epub 1993/08/01.PubMedCrossRef Schrander JJ, van den Bogart JP, Forget PP, Schrander-Stumpel CT, Kuijten RH, Kester AD. Cow's milk protein intolerance in infants under 1 year of age: a prospective epidemiological study. Eur J Pediatr. 1993;152(8):640–4. Epub 1993/08/01.PubMedCrossRef
8.
go back to reference • Osborne NJ, Koplin JJ, Martin PE, Gurrin LC, Lowe AJ, Matheson MC, et al. Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants. J Allergy Clin Immunol. 2011;127(3):668–76. e1-2. Epub 2011/03/08. This population-based study of 2,848 one-year-old infants in Australia provided cow’s milk allergy prevalence data.PubMedCrossRef • Osborne NJ, Koplin JJ, Martin PE, Gurrin LC, Lowe AJ, Matheson MC, et al. Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants. J Allergy Clin Immunol. 2011;127(3):668–76. e1-2. Epub 2011/03/08. This population-based study of 2,848 one-year-old infants in Australia provided cow’s milk allergy prevalence data.PubMedCrossRef
9.
go back to reference Osterballe M, Hansen TK, Mortz CG, Host A, Bindslev-Jensen C. The prevalence of food hypersensitivity in an unselected population of children and adults. Pediatr Allergy Immunol: Off Publ Eur Soc Pediatr Allergy Immunol. 2005;16(7):567–73. Epub 2005/10/22. Osterballe M, Hansen TK, Mortz CG, Host A, Bindslev-Jensen C. The prevalence of food hypersensitivity in an unselected population of children and adults. Pediatr Allergy Immunol: Off Publ Eur Soc Pediatr Allergy Immunol. 2005;16(7):567–73. Epub 2005/10/22.
10.
go back to reference Jarvinen KM, Sicherer SH, Sampson HA, Nowak-Wegrzyn A. Use of multiple doses of epinephrine in food-induced anaphylaxis in children. J Allergy Clin Immunol. 2008;122(1):133–8. Epub 2008/06/13.PubMedCrossRef Jarvinen KM, Sicherer SH, Sampson HA, Nowak-Wegrzyn A. Use of multiple doses of epinephrine in food-induced anaphylaxis in children. J Allergy Clin Immunol. 2008;122(1):133–8. Epub 2008/06/13.PubMedCrossRef
11.
go back to reference Du Toit G. Food-dependent exercise-induced anaphylaxis in childhood. Pediatr Allergy Immunol: Off Publ Eur Soc Pediatr Allergy Immunol. 2007;18(5):455–63. Epub 2007/07/10. Du Toit G. Food-dependent exercise-induced anaphylaxis in childhood. Pediatr Allergy Immunol: Off Publ Eur Soc Pediatr Allergy Immunol. 2007;18(5):455–63. Epub 2007/07/10.
12.
go back to reference Wal JM. Bovine milk allergenicity. Ann Allergy Asthma Immunol. 2004;93(5 Suppl 3):S2–11. Epub 2004/11/26.PubMedCrossRef Wal JM. Bovine milk allergenicity. Ann Allergy Asthma Immunol. 2004;93(5 Suppl 3):S2–11. Epub 2004/11/26.PubMedCrossRef
13.
go back to reference Restani P, Ballabio C, Di Lorenzo C, Tripodi S, Fiocchi A. Molecular aspects of milk allergens and their role in clinical events. Anal Bioanal Chem. 2009;395(1):47–56. Epub 2009/07/07.PubMedCrossRef Restani P, Ballabio C, Di Lorenzo C, Tripodi S, Fiocchi A. Molecular aspects of milk allergens and their role in clinical events. Anal Bioanal Chem. 2009;395(1):47–56. Epub 2009/07/07.PubMedCrossRef
14.
go back to reference Docena GH, Fernandez R, Chirdo FG, Fossati CA. Identification of casein as the major allergenic and antigenic protein of cow's milk. Allergy. 1996;51(6):412–6. Epub 1996/06/01.PubMed Docena GH, Fernandez R, Chirdo FG, Fossati CA. Identification of casein as the major allergenic and antigenic protein of cow's milk. Allergy. 1996;51(6):412–6. Epub 1996/06/01.PubMed
15.
go back to reference Natale M, Bisson C, Monti G, Peltran A, Garoffo LP, Valentini S, et al. Cow's milk allergens identification by two-dimensional immunoblotting and mass spectrometry. Mol Nutr Food Res. 2004;48(5):363–9. Epub 2005/01/27.PubMedCrossRef Natale M, Bisson C, Monti G, Peltran A, Garoffo LP, Valentini S, et al. Cow's milk allergens identification by two-dimensional immunoblotting and mass spectrometry. Mol Nutr Food Res. 2004;48(5):363–9. Epub 2005/01/27.PubMedCrossRef
16.
go back to reference Gaudin JC, Rabesona H, Choiset Y, Yeretssian G, Chobert JM, Sakanyan V, et al. Assessment of the immunoglobulin E-mediated immune response to milk-specific proteins in allergic patients using microarrays. Clin Exp Allergy. 2008;38(4):686–93. Epub 2008/03/01.PubMedCrossRef Gaudin JC, Rabesona H, Choiset Y, Yeretssian G, Chobert JM, Sakanyan V, et al. Assessment of the immunoglobulin E-mediated immune response to milk-specific proteins in allergic patients using microarrays. Clin Exp Allergy. 2008;38(4):686–93. Epub 2008/03/01.PubMedCrossRef
17.
go back to reference Chen WL, Hwang MT, Liau CY, Ho JC, Hong KC, Mao SJ. Beta-lactoglobulin is a thermal marker in processed milk as studied by electrophoresis and circular dichroic spectra. J Dairy Sci. 2005;88(5):1618–30. Epub 2005/04/15.PubMedCrossRef Chen WL, Hwang MT, Liau CY, Ho JC, Hong KC, Mao SJ. Beta-lactoglobulin is a thermal marker in processed milk as studied by electrophoresis and circular dichroic spectra. J Dairy Sci. 2005;88(5):1618–30. Epub 2005/04/15.PubMedCrossRef
18.
go back to reference Ehn BM, Ekstrand B, Bengtsson U, Ahlstedt S. Modification of IgE binding during heat processing of the cow's milk allergen beta-lactoglobulin. J Agric Food Chem. 2004;52(5):1398–403. Epub 2004/03/05.PubMedCrossRef Ehn BM, Ekstrand B, Bengtsson U, Ahlstedt S. Modification of IgE binding during heat processing of the cow's milk allergen beta-lactoglobulin. J Agric Food Chem. 2004;52(5):1398–403. Epub 2004/03/05.PubMedCrossRef
19.
go back to reference Nowak-Wegrzyn A, Bloom KA, Sicherer SH, Shreffler WG, Noone S, Wanich N, et al. Tolerance to extensively heated milk in children with cow's milk allergy. J Allergy Clin Immunol. 2008;122(2):342–7. 7 e1-2. Epub 2008/07/16.PubMedCrossRef Nowak-Wegrzyn A, Bloom KA, Sicherer SH, Shreffler WG, Noone S, Wanich N, et al. Tolerance to extensively heated milk in children with cow's milk allergy. J Allergy Clin Immunol. 2008;122(2):342–7. 7 e1-2. Epub 2008/07/16.PubMedCrossRef
20.
go back to reference • Jyonouchi S, Abraham V, Orange JS, Spergel JM, Gober L, Dudek E, et al. Invariant natural killer T cells from children with versus without food allergy exhibit differential responsiveness to milk-derived sphingomyelin. J Allergy Clin Immunol. 2011;128(1):102–9. e13. Epub 2011/04/05. This study introduced a novel mechanism in cow’s milk allergy. Milk sphingomyelin was shown to induce invariant natural kill T-cell activation and T H 2 cytokine production that is more exuberant in children with IgE-mediated CMA.PubMedCrossRef • Jyonouchi S, Abraham V, Orange JS, Spergel JM, Gober L, Dudek E, et al. Invariant natural killer T cells from children with versus without food allergy exhibit differential responsiveness to milk-derived sphingomyelin. J Allergy Clin Immunol. 2011;128(1):102–9. e13. Epub 2011/04/05. This study introduced a novel mechanism in cow’s milk allergy. Milk sphingomyelin was shown to induce invariant natural kill T-cell activation and T H 2 cytokine production that is more exuberant in children with IgE-mediated CMA.PubMedCrossRef
21.
go back to reference Fiocchi A, Terracciano L, Bouygue GR, Veglia F, Sarratud T, Martelli A, et al. Incremental prognostic factors associated with cow's milk allergy outcomes in infant and child referrals: the Milan Cow's Milk Allergy Cohort study. Ann Allergy Asthma Immunol. 2008;101(2):166–73. Epub 2008/08/30.PubMedCrossRef Fiocchi A, Terracciano L, Bouygue GR, Veglia F, Sarratud T, Martelli A, et al. Incremental prognostic factors associated with cow's milk allergy outcomes in infant and child referrals: the Milan Cow's Milk Allergy Cohort study. Ann Allergy Asthma Immunol. 2008;101(2):166–73. Epub 2008/08/30.PubMedCrossRef
22.
go back to reference Bishop JM, Hill DJ, Hosking CS. Natural history of cow milk allergy: clinical outcome. J Pediatr. 1990;116(6):862–7. Epub 1990/06/01.PubMedCrossRef Bishop JM, Hill DJ, Hosking CS. Natural history of cow milk allergy: clinical outcome. J Pediatr. 1990;116(6):862–7. Epub 1990/06/01.PubMedCrossRef
23.
go back to reference Skripak JM, Matsui EC, Mudd K, Wood RA. The natural history of IgE-mediated cow's milk allergy. J Allergy Clin Immunol. 2007;120(5):1172–7. Epub 2007/10/16.PubMedCrossRef Skripak JM, Matsui EC, Mudd K, Wood RA. The natural history of IgE-mediated cow's milk allergy. J Allergy Clin Immunol. 2007;120(5):1172–7. Epub 2007/10/16.PubMedCrossRef
24.
go back to reference Elizur A, Rajuan N, Goldberg MR, Leshno M, Cohen A, Katz Y. Natural course and risk factors for persistence of IgE-mediated cow's milk allergy. Journal Pediatr. 2012. Epub 2012/04/07. Elizur A, Rajuan N, Goldberg MR, Leshno M, Cohen A, Katz Y. Natural course and risk factors for persistence of IgE-mediated cow's milk allergy. Journal Pediatr. 2012. Epub 2012/04/07.
25.
go back to reference Allen KJ, Davidson GP, Day AS, Hill DJ, Kemp AS, Peake JE, et al. Management of cow's milk protein allergy in infants and young children: an expert panel perspective. J Paediatr Child Health. 2009;45(9):481–6. Epub 2009/08/26.PubMedCrossRef Allen KJ, Davidson GP, Day AS, Hill DJ, Kemp AS, Peake JE, et al. Management of cow's milk protein allergy in infants and young children: an expert panel perspective. J Paediatr Child Health. 2009;45(9):481–6. Epub 2009/08/26.PubMedCrossRef
26.
go back to reference Sampson HA. Update on food allergy. J Allergy Clin Immunol. 2004;113(5):805–19. quiz 20. Epub 2004/05/08.PubMedCrossRef Sampson HA. Update on food allergy. J Allergy Clin Immunol. 2004;113(5):805–19. quiz 20. Epub 2004/05/08.PubMedCrossRef
27.
go back to reference Host A, Halken S, Jacobsen HP, Christensen AE, Herskind AM, Plesner K. Clinical course of cow's milk protein allergy/intolerance and atopic diseases in childhood. Pediatr Allergy Immunol: Off Publ Eur Soc Pediatr Allergy Immunol. 2002;13 Suppl 15:23–8. Epub 2003/04/12. Host A, Halken S, Jacobsen HP, Christensen AE, Herskind AM, Plesner K. Clinical course of cow's milk protein allergy/intolerance and atopic diseases in childhood. Pediatr Allergy Immunol: Off Publ Eur Soc Pediatr Allergy Immunol. 2002;13 Suppl 15:23–8. Epub 2003/04/12.
28.
go back to reference Kvenshagen B, Halvorsen R, Jacobsen M. Adverse reactions to milk in infants. Acta Paediatr. 2008;97(2):196–200. Epub 2008/02/08.PubMedCrossRef Kvenshagen B, Halvorsen R, Jacobsen M. Adverse reactions to milk in infants. Acta Paediatr. 2008;97(2):196–200. Epub 2008/02/08.PubMedCrossRef
29.
go back to reference Venter C, Pereira B, Grundy J, Clayton CB, Roberts G, Higgins B, et al. Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life. J Allergy Clin Immunol. 2006;117(5):1118–24. Epub 2006/05/06.PubMedCrossRef Venter C, Pereira B, Grundy J, Clayton CB, Roberts G, Higgins B, et al. Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life. J Allergy Clin Immunol. 2006;117(5):1118–24. Epub 2006/05/06.PubMedCrossRef
30.
go back to reference Bock SA, Munoz-Furlong A, Sampson HA. Further fatalities caused by anaphylactic reactions to food, 2001–2006. J Allergy Clin Immunol. 2007;119(4):1016–8. Epub 2007/02/20.PubMedCrossRef Bock SA, Munoz-Furlong A, Sampson HA. Further fatalities caused by anaphylactic reactions to food, 2001–2006. J Allergy Clin Immunol. 2007;119(4):1016–8. Epub 2007/02/20.PubMedCrossRef
31.
go back to reference Pumphrey RS. Fatal anaphylaxis in the UK, 1992–2001. Novartis Found Symp. 2004;257:116–28. discussion 28–32, 57–60, 276–85. Epub 2004/03/18.PubMedCrossRef Pumphrey RS. Fatal anaphylaxis in the UK, 1992–2001. Novartis Found Symp. 2004;257:116–28. discussion 28–32, 57–60, 276–85. Epub 2004/03/18.PubMedCrossRef
32.
go back to reference Sampson HA, Mendelson L, Rosen JP. Fatal and near-fatal anaphylactic reactions to food in children and adolescents. N Engl J Med. 1992;327(6):380–4. Epub 1992/08/06.PubMedCrossRef Sampson HA, Mendelson L, Rosen JP. Fatal and near-fatal anaphylactic reactions to food in children and adolescents. N Engl J Med. 1992;327(6):380–4. Epub 1992/08/06.PubMedCrossRef
33.
go back to reference Levy MB, Goldberg MR, Nachshon L, Tabachnik E, Katz Y. Lessons from cases of mortality due to food allergy in Israel: cow's milk protein should be considered a potentially fatal allergen. Isr Med Assoc J. 14(1):29–33. Epub 2012/05/26. Levy MB, Goldberg MR, Nachshon L, Tabachnik E, Katz Y. Lessons from cases of mortality due to food allergy in Israel: cow's milk protein should be considered a potentially fatal allergen. Isr Med Assoc J. 14(1):29–33. Epub 2012/05/26.
34.
go back to reference •• Fleisher DM, Perry T, Atkins A, Wood RA, Burks W, Jones SM, et al. Allergic reactions to foods in preschool-aged children in a prospective observational food allergy study. Pediatrics. 2012. Epub June 25, 2012. This prospective, five-site observational study of 512 infants with CMA reported that allergic reactions were most frequently triggered by milk. They also reported that reaction severity was not statistically different between those induced by peanuts and those induced by milk. •• Fleisher DM, Perry T, Atkins A, Wood RA, Burks W, Jones SM, et al. Allergic reactions to foods in preschool-aged children in a prospective observational food allergy study. Pediatrics. 2012. Epub June 25, 2012. This prospective, five-site observational study of 512 infants with CMA reported that allergic reactions were most frequently triggered by milk. They also reported that reaction severity was not statistically different between those induced by peanuts and those induced by milk.
35.
go back to reference Fiocchi A, Schunemann HJ, Brozek J, Restani P, Beyer K, Troncone R, et al. Diagnosis and Rationale for Action Against Cow's Milk Allergy (DRACMA): a summary report. J Allergy Clin Immunol. 2010;126(6):1119–28. e12. Epub 2010/12/08.PubMedCrossRef Fiocchi A, Schunemann HJ, Brozek J, Restani P, Beyer K, Troncone R, et al. Diagnosis and Rationale for Action Against Cow's Milk Allergy (DRACMA): a summary report. J Allergy Clin Immunol. 2010;126(6):1119–28. e12. Epub 2010/12/08.PubMedCrossRef
36.
go back to reference Panel NI-SE, Boyce JA, Assa’ad A, Burks AW, Jones SM, Sampson HA, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol. 2010;126(6 Suppl):S1–58. Epub 2010/12/16. Panel NI-SE, Boyce JA, Assa’ad A, Burks AW, Jones SM, Sampson HA, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol. 2010;126(6 Suppl):S1–58. Epub 2010/12/16.
37.
go back to reference Perry TT, Matsui EC, Kay Conover-Walker M, Wood RA. The relationship of allergen-specific IgE levels and oral food challenge outcome. J Allergy Clin Immunol. 2004;114(1):144–9. Epub 2004/07/09.PubMedCrossRef Perry TT, Matsui EC, Kay Conover-Walker M, Wood RA. The relationship of allergen-specific IgE levels and oral food challenge outcome. J Allergy Clin Immunol. 2004;114(1):144–9. Epub 2004/07/09.PubMedCrossRef
38.
go back to reference Hill DJ, Heine RG, Hosking CS. The diagnostic value of skin prick testing in children with food allergy. Pediatr Allergy Immunol: Off Publ Eur Soc Pediatr Allergy Immunol. 2004;15(5):435–41. Epub 2004/10/16. Hill DJ, Heine RG, Hosking CS. The diagnostic value of skin prick testing in children with food allergy. Pediatr Allergy Immunol: Off Publ Eur Soc Pediatr Allergy Immunol. 2004;15(5):435–41. Epub 2004/10/16.
39.
go back to reference Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol. 2001;107(5):891–6. Epub 2001/05/10.PubMedCrossRef Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol. 2001;107(5):891–6. Epub 2001/05/10.PubMedCrossRef
40.
go back to reference Garcia-Ara C, Boyano-Martinez T, Diaz-Pena JM, Martin-Munoz F, Reche-Frutos M, Martin-Esteban M. Specific IgE levels in the diagnosis of immediate hypersensitivity to cows' milk protein in the infant. J Allergy Clin Immunol. 2001;107(1):185–90. Epub 2001/01/10.PubMedCrossRef Garcia-Ara C, Boyano-Martinez T, Diaz-Pena JM, Martin-Munoz F, Reche-Frutos M, Martin-Esteban M. Specific IgE levels in the diagnosis of immediate hypersensitivity to cows' milk protein in the infant. J Allergy Clin Immunol. 2001;107(1):185–90. Epub 2001/01/10.PubMedCrossRef
41.
go back to reference Wang J, Godbold JH, Sampson HA. Correlation of serum allergy (IgE) tests performed by different assay systems. J Allergy Clin Immunol. 2008;121(5):1219–24. Epub 2008/02/05.PubMedCrossRef Wang J, Godbold JH, Sampson HA. Correlation of serum allergy (IgE) tests performed by different assay systems. J Allergy Clin Immunol. 2008;121(5):1219–24. Epub 2008/02/05.PubMedCrossRef
42.
go back to reference Hamilton RG, Mudd K, White MA, Wood RA. Extension of food allergen specific IgE ranges from the ImmunoCAP to the IMMULITE systems. Ann Allergy Asthma Immunol. 2011;107(2):139–44. Epub 2011/08/02.PubMedCrossRef Hamilton RG, Mudd K, White MA, Wood RA. Extension of food allergen specific IgE ranges from the ImmunoCAP to the IMMULITE systems. Ann Allergy Asthma Immunol. 2011;107(2):139–44. Epub 2011/08/02.PubMedCrossRef
43.
go back to reference Kim TE, Park SW, Cho NY, Choi SY, Yong TS, Nahm BH, et al. Quantitative measurement of serum allergen-specific IgE on protein chip. Exp Mol Med. 2002;34(2):152–8. Epub 2002/06/28.PubMed Kim TE, Park SW, Cho NY, Choi SY, Yong TS, Nahm BH, et al. Quantitative measurement of serum allergen-specific IgE on protein chip. Exp Mol Med. 2002;34(2):152–8. Epub 2002/06/28.PubMed
44.
go back to reference Noh G, Ahn HS, Cho NY, Lee S, Oh JW. The clinical significance of food specific IgE/IgG4 in food specific atopic dermatitis. Pediatr Allergy Immunol: Off Publ Eur Soc Pediatr Allergy Immunol. 2007;18(1):63–70. Epub 2007/02/14. Noh G, Ahn HS, Cho NY, Lee S, Oh JW. The clinical significance of food specific IgE/IgG4 in food specific atopic dermatitis. Pediatr Allergy Immunol: Off Publ Eur Soc Pediatr Allergy Immunol. 2007;18(1):63–70. Epub 2007/02/14.
45.
go back to reference Ott H, Baron JM, Heise R, Ocklenburg C, Stanzel S, Merk HF, et al. Clinical usefulness of microarray-based IgE detection in children with suspected food allergy. Allergy. 2008;63(11):1521–8. Epub 2008/10/18.PubMedCrossRef Ott H, Baron JM, Heise R, Ocklenburg C, Stanzel S, Merk HF, et al. Clinical usefulness of microarray-based IgE detection in children with suspected food allergy. Allergy. 2008;63(11):1521–8. Epub 2008/10/18.PubMedCrossRef
46.
go back to reference •• Ito K, Futamura M, Moverare R, Tanaka A, Kawabe T, Sakamoto T, et al. The usefulness of casein-specific IgE and IgG4 antibodies in cow's milk allergic children. Clin Mol Allergy: CMA. 2012;10(1):1. Epub 2012/01/04. In this study, casein IgE was deemed the best discriminating test in children with CMA.PubMedCrossRef •• Ito K, Futamura M, Moverare R, Tanaka A, Kawabe T, Sakamoto T, et al. The usefulness of casein-specific IgE and IgG4 antibodies in cow's milk allergic children. Clin Mol Allergy: CMA. 2012;10(1):1. Epub 2012/01/04. In this study, casein IgE was deemed the best discriminating test in children with CMA.PubMedCrossRef
47.
go back to reference Garcia-Ara MC, Boyano-Martinez MT, Diaz-Pena JM, Martin-Munoz MF, Martin-Esteban M. Cow's milk-specific immunoglobulin E levels as predictors of clinical reactivity in the follow-up of the cow's milk allergy infants. Clin Exp Allergy. 2004;34(6):866–70. Epub 2004/06/16.PubMedCrossRef Garcia-Ara MC, Boyano-Martinez MT, Diaz-Pena JM, Martin-Munoz MF, Martin-Esteban M. Cow's milk-specific immunoglobulin E levels as predictors of clinical reactivity in the follow-up of the cow's milk allergy infants. Clin Exp Allergy. 2004;34(6):866–70. Epub 2004/06/16.PubMedCrossRef
48.
go back to reference Fiocchi A, Restani P, Riva E. Beef allergy in children. Nutrition. 2000;16(6):454–7. Epub 2000/06/28.PubMedCrossRef Fiocchi A, Restani P, Riva E. Beef allergy in children. Nutrition. 2000;16(6):454–7. Epub 2000/06/28.PubMedCrossRef
49.
go back to reference Werfel SJ, Cooke SK, Sampson HA. Clinical reactivity to beef in children allergic to cow's milk. J Allergy Clin Immunol. 1997;99(3):293–300. Epub 1997/03/01.PubMedCrossRef Werfel SJ, Cooke SK, Sampson HA. Clinical reactivity to beef in children allergic to cow's milk. J Allergy Clin Immunol. 1997;99(3):293–300. Epub 1997/03/01.PubMedCrossRef
50.
go back to reference Osborn DA, Sinn J. Formulas containing hydrolysed protein for prevention of allergy and food intolerance in infants. Cochrane Database Syst Rev. 2006;(4):CD003664. Epub 2006/10/21. Osborn DA, Sinn J. Formulas containing hydrolysed protein for prevention of allergy and food intolerance in infants. Cochrane Database Syst Rev. 2006;(4):CD003664. Epub 2006/10/21.
51.
go back to reference Lowe AJ, Hosking CS, Bennett CM, Allen KJ, Axelrad C, Carlin JB, et al. Effect of a partially hydrolyzed whey infant formula at weaning on risk of allergic disease in high-risk children: a randomized controlled trial. J Allergy Clin Immunol. 2011;128(2):360–5. e4. Epub 2011/06/24.PubMedCrossRef Lowe AJ, Hosking CS, Bennett CM, Allen KJ, Axelrad C, Carlin JB, et al. Effect of a partially hydrolyzed whey infant formula at weaning on risk of allergic disease in high-risk children: a randomized controlled trial. J Allergy Clin Immunol. 2011;128(2):360–5. e4. Epub 2011/06/24.PubMedCrossRef
52.
go back to reference von Berg A, Filipiak-Pittroff B, Kramer U, Link E, Bollrath C, Brockow I, et al. Preventive effect of hydrolyzed infant formulas persists until age 6 years: long-term results from the German Infant Nutritional Intervention Study (GINI). J Allergy Clin Immunol. 2008;121(6):1442–7. Epub 2008/06/10.CrossRef von Berg A, Filipiak-Pittroff B, Kramer U, Link E, Bollrath C, Brockow I, et al. Preventive effect of hydrolyzed infant formulas persists until age 6 years: long-term results from the German Infant Nutritional Intervention Study (GINI). J Allergy Clin Immunol. 2008;121(6):1442–7. Epub 2008/06/10.CrossRef
53.
go back to reference von Berg A, Koletzko S, Filipiak-Pittroff B, Laubereau B, Grubl A, Wichmann HE, et al. Certain hydrolyzed formulas reduce the incidence of atopic dermatitis but not that of asthma: three-year results of the German Infant Nutritional Intervention Study. J Allergy Clin Immunol. 2007;119(3):718–25. Epub 2007/01/24.CrossRef von Berg A, Koletzko S, Filipiak-Pittroff B, Laubereau B, Grubl A, Wichmann HE, et al. Certain hydrolyzed formulas reduce the incidence of atopic dermatitis but not that of asthma: three-year results of the German Infant Nutritional Intervention Study. J Allergy Clin Immunol. 2007;119(3):718–25. Epub 2007/01/24.CrossRef
54.
go back to reference von Berg A, Koletzko S, Grubl A, Filipiak-Pittroff B, Wichmann HE, Bauer CP, et al. The effect of hydrolyzed cow's milk formula for allergy prevention in the first year of life: the German Infant Nutritional Intervention Study, a randomized double-blind trial. J Allergy Clin Immunol. 2003;111(3):533–40. Epub 2003/03/19.CrossRef von Berg A, Koletzko S, Grubl A, Filipiak-Pittroff B, Wichmann HE, Bauer CP, et al. The effect of hydrolyzed cow's milk formula for allergy prevention in the first year of life: the German Infant Nutritional Intervention Study, a randomized double-blind trial. J Allergy Clin Immunol. 2003;111(3):533–40. Epub 2003/03/19.CrossRef
55.
go back to reference Christie L, Hine RJ, Parker JG, Burks W. Food allergies in children affect nutrient intake and growth. J Am Diet Assoc. 2002;102(11):1648–51. Epub 2002/11/27.PubMedCrossRef Christie L, Hine RJ, Parker JG, Burks W. Food allergies in children affect nutrient intake and growth. J Am Diet Assoc. 2002;102(11):1648–51. Epub 2002/11/27.PubMedCrossRef
56.
go back to reference Tiainen JM, Nuutinen OM, Kalavainen MP. Diet and nutritional status in children with cow's milk allergy. Eur J Clin Nutr. 1995;49(8):605–12. Epub 1995/08/01.PubMed Tiainen JM, Nuutinen OM, Kalavainen MP. Diet and nutritional status in children with cow's milk allergy. Eur J Clin Nutr. 1995;49(8):605–12. Epub 1995/08/01.PubMed
57.
go back to reference Carvalho NF, Kenney RD, Carrington PH, Hall DE. Severe nutritional deficiencies in toddlers resulting from health food milk alternatives. Pediatrics. 2001;107(4):E46. Epub 2001/05/23.PubMedCrossRef Carvalho NF, Kenney RD, Carrington PH, Hall DE. Severe nutritional deficiencies in toddlers resulting from health food milk alternatives. Pediatrics. 2001;107(4):E46. Epub 2001/05/23.PubMedCrossRef
58.
go back to reference Nguyen J, Cazassus F, Atallah A, Baba N, Sibille G, Coriatt D. [Kwashiorkor after an exclusion diet for eczema]. Presse Med. 2001;30(30):1496–7. Epub 2001/11/20. Kwashiorkor apres regime d'eviction pour eczema.PubMed Nguyen J, Cazassus F, Atallah A, Baba N, Sibille G, Coriatt D. [Kwashiorkor after an exclusion diet for eczema]. Presse Med. 2001;30(30):1496–7. Epub 2001/11/20. Kwashiorkor apres regime d'eviction pour eczema.PubMed
59.
go back to reference Novembre E, Leo G, Cianferoni A, Bernardini R, Pucci N, Vierucci A. Severe hypoproteinemia in infant with AD. Allergy. 2003;58(1):88–9. Epub 2003/02/13.PubMedCrossRef Novembre E, Leo G, Cianferoni A, Bernardini R, Pucci N, Vierucci A. Severe hypoproteinemia in infant with AD. Allergy. 2003;58(1):88–9. Epub 2003/02/13.PubMedCrossRef
60.
go back to reference Host A, Koletzko B, Dreborg S, Muraro A, Wahn U, Aggett P, et al. Dietary products used in infants for treatment and prevention of food allergy. Joint Statement of the European Society for Paediatric Allergology and Clinical Immunology (ESPACI) Committee on Hypoallergenic Formulas and the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Committee on Nutrition. Arch Dis Child. 1999;81(1):80–4. Epub 1999/06/18.PubMedCrossRef Host A, Koletzko B, Dreborg S, Muraro A, Wahn U, Aggett P, et al. Dietary products used in infants for treatment and prevention of food allergy. Joint Statement of the European Society for Paediatric Allergology and Clinical Immunology (ESPACI) Committee on Hypoallergenic Formulas and the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Committee on Nutrition. Arch Dis Child. 1999;81(1):80–4. Epub 1999/06/18.PubMedCrossRef
61.
go back to reference Kemp AS, Hill DJ, Allen KJ, Anderson K, Davidson GP, Day AS, et al. Guidelines for the use of infant formulas to treat cows milk protein allergy: an Australian consensus panel opinion. Med J Aust. 2008;188(2):109–12. Epub 2008/01/22.PubMed Kemp AS, Hill DJ, Allen KJ, Anderson K, Davidson GP, Day AS, et al. Guidelines for the use of infant formulas to treat cows milk protein allergy: an Australian consensus panel opinion. Med J Aust. 2008;188(2):109–12. Epub 2008/01/22.PubMed
62.
go back to reference Vandenplas Y, Koletzko S, Isolauri E, Hill D, Oranje AP, Brueton M, et al. Guidelines for the diagnosis and management of cow's milk protein allergy in infants. Arch Dis Child. 2007;92(10):902–8. Epub 2007/09/27.PubMedCrossRef Vandenplas Y, Koletzko S, Isolauri E, Hill D, Oranje AP, Brueton M, et al. Guidelines for the diagnosis and management of cow's milk protein allergy in infants. Arch Dis Child. 2007;92(10):902–8. Epub 2007/09/27.PubMedCrossRef
63.
go back to reference Jarvinen KM, Makinen-Kiljunen S, Suomalainen H. Cow's milk challenge through human milk evokes immune responses in infants with cow's milk allergy. J Pediatr. 1999;135(4):506–12. Epub 1999/10/13.PubMedCrossRef Jarvinen KM, Makinen-Kiljunen S, Suomalainen H. Cow's milk challenge through human milk evokes immune responses in infants with cow's milk allergy. J Pediatr. 1999;135(4):506–12. Epub 1999/10/13.PubMedCrossRef
64.
go back to reference Lifschitz CH, Hawkins HK, Guerra C, Byrd N. Anaphylactic shock due to cow's milk protein hypersensitivity in a breast-fed infant. J Pediatr Gastroenterol Nutr. 1988;7(1):141–4. Epub 1988/01/01.PubMedCrossRef Lifschitz CH, Hawkins HK, Guerra C, Byrd N. Anaphylactic shock due to cow's milk protein hypersensitivity in a breast-fed infant. J Pediatr Gastroenterol Nutr. 1988;7(1):141–4. Epub 1988/01/01.PubMedCrossRef
65.
go back to reference American Academy of Pediatrics. Committee on Nutrition. Hypoallergenic infant formulas. Pediatrics. 2000;106(2 Pt 1):346–9. Epub 2000/08/02. American Academy of Pediatrics. Committee on Nutrition. Hypoallergenic infant formulas. Pediatrics. 2000;106(2 Pt 1):346–9. Epub 2000/08/02.
66.
go back to reference Durham SR, Walker SM, Varga EM, Jacobson MR, O'Brien F, Noble W, et al. Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med. 1999;341(7):468–75. Epub 1999/08/12.PubMedCrossRef Durham SR, Walker SM, Varga EM, Jacobson MR, O'Brien F, Noble W, et al. Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med. 1999;341(7):468–75. Epub 1999/08/12.PubMedCrossRef
67.
go back to reference Goldberg A, Confino-Cohen R. Bee venom immunotherapy - how early is it effective? Allergy. 2010;65(3):391–5. Epub 2009/10/21.PubMedCrossRef Goldberg A, Confino-Cohen R. Bee venom immunotherapy - how early is it effective? Allergy. 2010;65(3):391–5. Epub 2009/10/21.PubMedCrossRef
68.
go back to reference Lerch E, Muller UR. Long-term protection after stopping venom immunotherapy: results of re-stings in 200 patients. J Allergy Clin Immunol. 1998;101(5):606–12. Epub 1998/05/26.PubMedCrossRef Lerch E, Muller UR. Long-term protection after stopping venom immunotherapy: results of re-stings in 200 patients. J Allergy Clin Immunol. 1998;101(5):606–12. Epub 1998/05/26.PubMedCrossRef
69.
go back to reference Muller U, Thurnheer U, Patrizzi R, Spiess J, Hoigne R. Immunotherapy in bee sting hypersensitivity. Bee venom versus wholebody extract. Allergy. 1979;34(6):369–78. Epub 1979/12/01.PubMedCrossRef Muller U, Thurnheer U, Patrizzi R, Spiess J, Hoigne R. Immunotherapy in bee sting hypersensitivity. Bee venom versus wholebody extract. Allergy. 1979;34(6):369–78. Epub 1979/12/01.PubMedCrossRef
70.
go back to reference Nelson HS. Advances in upper airway diseases and allergen immunotherapy. J Allergy Clin Immunol. 2004;113(4):635–42. Epub 2004/04/22.PubMedCrossRef Nelson HS. Advances in upper airway diseases and allergen immunotherapy. J Allergy Clin Immunol. 2004;113(4):635–42. Epub 2004/04/22.PubMedCrossRef
71.
go back to reference Norman PS. Immunotherapy: 1999–2004. J Allergy Clin Immunol. 2004;113(6):1013–23. quiz 24. Epub 2004/06/23.PubMedCrossRef Norman PS. Immunotherapy: 1999–2004. J Allergy Clin Immunol. 2004;113(6):1013–23. quiz 24. Epub 2004/06/23.PubMedCrossRef
72.
go back to reference Ross RN, Nelson HS, Finegold I. Effectiveness of specific immunotherapy in the treatment of allergic rhinitis: an analysis of randomized, prospective, single- or double-blind, placebo-controlled studies. Clin Ther. 2000;22(3):342–50. Epub 2000/08/30.PubMedCrossRef Ross RN, Nelson HS, Finegold I. Effectiveness of specific immunotherapy in the treatment of allergic rhinitis: an analysis of randomized, prospective, single- or double-blind, placebo-controlled studies. Clin Ther. 2000;22(3):342–50. Epub 2000/08/30.PubMedCrossRef
73.
go back to reference Walker SM, Pajno GB, Lima MT, Wilson DR, Durham SR. Grass pollen immunotherapy for seasonal rhinitis and asthma: a randomized, controlled trial. J Allergy Clin Immunol. 2001;107(1):87–93. Epub 2001/01/10.PubMedCrossRef Walker SM, Pajno GB, Lima MT, Wilson DR, Durham SR. Grass pollen immunotherapy for seasonal rhinitis and asthma: a randomized, controlled trial. J Allergy Clin Immunol. 2001;107(1):87–93. Epub 2001/01/10.PubMedCrossRef
74.
go back to reference Oppenheimer JJ, Nelson HS, Bock SA, Christensen F, Leung DY. Treatment of peanut allergy with rush immunotherapy. J Allergy Clin Immunol. 1992;90(2):256–62. Epub 1992/08/01.PubMedCrossRef Oppenheimer JJ, Nelson HS, Bock SA, Christensen F, Leung DY. Treatment of peanut allergy with rush immunotherapy. J Allergy Clin Immunol. 1992;90(2):256–62. Epub 1992/08/01.PubMedCrossRef
75.
go back to reference Nelson HS, Lahr J, Rule R, Bock A, Leung D. Treatment of anaphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract. J Allergy Clin Immunol. 1997;99(6 Pt 1):744–51. Epub 1997/06/01.PubMedCrossRef Nelson HS, Lahr J, Rule R, Bock A, Leung D. Treatment of anaphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract. J Allergy Clin Immunol. 1997;99(6 Pt 1):744–51. Epub 1997/06/01.PubMedCrossRef
76.
go back to reference Skripak JM, Nash SD, Rowley H, Brereton NH, Oh S, Hamilton RG, et al. A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy. J Allergy Clin Immunol. 2008;122(6):1154–60. Epub 2008/10/28.PubMedCrossRef Skripak JM, Nash SD, Rowley H, Brereton NH, Oh S, Hamilton RG, et al. A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy. J Allergy Clin Immunol. 2008;122(6):1154–60. Epub 2008/10/28.PubMedCrossRef
77.
go back to reference Longo G, Barbi E, Berti I, Meneghetti R, Pittalis A, Ronfani L, et al. Specific oral tolerance induction in children with very severe cow's milk-induced reactions. J Allergy Clin Immunol. 2008;121(2):343–7. Epub 2007/12/26.PubMedCrossRef Longo G, Barbi E, Berti I, Meneghetti R, Pittalis A, Ronfani L, et al. Specific oral tolerance induction in children with very severe cow's milk-induced reactions. J Allergy Clin Immunol. 2008;121(2):343–7. Epub 2007/12/26.PubMedCrossRef
78.
go back to reference Martorell A, De la Hoz B, Ibanez MD, Bone J, Terrados MS, Michavila A, et al. Oral desensitization as a useful treatment in 2-year-old children with cow's milk allergy. Clin Exp Allergy. 2011;41(9):1297–304. Epub 2011/04/13.PubMedCrossRef Martorell A, De la Hoz B, Ibanez MD, Bone J, Terrados MS, Michavila A, et al. Oral desensitization as a useful treatment in 2-year-old children with cow's milk allergy. Clin Exp Allergy. 2011;41(9):1297–304. Epub 2011/04/13.PubMedCrossRef
79.
go back to reference Morisset M, Moneret-Vautrin DA, Guenard L, Cuny JM, Frentz P, Hatahet R, et al. Oral desensitization in children with milk and egg allergies obtains recovery in a significant proportion of cases. A randomized study in 60 children with cow's milk allergy and 90 children with egg allergy. Eur Ann Allergy Clin Immunol. 2007;39(1):12–9. Epub 2007/03/23.PubMed Morisset M, Moneret-Vautrin DA, Guenard L, Cuny JM, Frentz P, Hatahet R, et al. Oral desensitization in children with milk and egg allergies obtains recovery in a significant proportion of cases. A randomized study in 60 children with cow's milk allergy and 90 children with egg allergy. Eur Ann Allergy Clin Immunol. 2007;39(1):12–9. Epub 2007/03/23.PubMed
80.
go back to reference Pajno GB, Caminiti L, Ruggeri P, De Luca R, Vita D, La Rosa M, et al. Oral immunotherapy for cow's milk allergy with a weekly up-dosing regimen: a randomized single-blind controlled study. Ann Allergy Asthma Immunol. 2010;105(5):376–81. Epub 2010/11/09.PubMedCrossRef Pajno GB, Caminiti L, Ruggeri P, De Luca R, Vita D, La Rosa M, et al. Oral immunotherapy for cow's milk allergy with a weekly up-dosing regimen: a randomized single-blind controlled study. Ann Allergy Asthma Immunol. 2010;105(5):376–81. Epub 2010/11/09.PubMedCrossRef
81.
go back to reference Brozek JL, Terracciano L, Hsu J, Kreis J, Compalati E, Santesso N, et al. Oral immunotherapy for IgE-mediated cow's milk allergy: a systematic review and meta-analysis. Clin Exp Allergy. 42(3):363–74. Epub 2012/02/24. Brozek JL, Terracciano L, Hsu J, Kreis J, Compalati E, Santesso N, et al. Oral immunotherapy for IgE-mediated cow's milk allergy: a systematic review and meta-analysis. Clin Exp Allergy. 42(3):363–74. Epub 2012/02/24.
82.
go back to reference Keet CA, Frischmeyer-Guerrerio PA, Thyagarajan A, Schroeder JT, Hamilton RG, Boden S, et al. The safety and efficacy of sublingual and oral immunotherapy for milk allergy. J Allergy Clin Immunol. 129(2):448–55, 55 e1-5. Epub 2011/12/02. Keet CA, Frischmeyer-Guerrerio PA, Thyagarajan A, Schroeder JT, Hamilton RG, Boden S, et al. The safety and efficacy of sublingual and oral immunotherapy for milk allergy. J Allergy Clin Immunol. 129(2):448–55, 55 e1-5. Epub 2011/12/02.
83.
go back to reference Dupont C, Kalach N, Soulaines P, Legoue-Morillon S, Piloquet H, Benhamou PH. Cow's milk epicutaneous immunotherapy in children: a pilot trial of safety, acceptability, and impact on allergic reactivity. J Allergy Clin Immunol. 2010;125(5):1165–7. Epub 2010/05/11.PubMedCrossRef Dupont C, Kalach N, Soulaines P, Legoue-Morillon S, Piloquet H, Benhamou PH. Cow's milk epicutaneous immunotherapy in children: a pilot trial of safety, acceptability, and impact on allergic reactivity. J Allergy Clin Immunol. 2010;125(5):1165–7. Epub 2010/05/11.PubMedCrossRef
84.
go back to reference Scurlock AM, Burks AW, Jones SM. Oral immunotherapy for food allergy. Curr Allergy Asthma Rep. 2009;9(3):186–93. Epub 2009/04/08.PubMedCrossRef Scurlock AM, Burks AW, Jones SM. Oral immunotherapy for food allergy. Curr Allergy Asthma Rep. 2009;9(3):186–93. Epub 2009/04/08.PubMedCrossRef
85.
go back to reference • Nadeau KC, Schneider LC, Hoyte L, Borras I, Umetsu DT. Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy. J Allergy Clin Immunol. 2011;127(6):1622–4. Epub 2011/05/07. In this pilot phase I study, omalizumab treatment combined with oral milk desensitization in children with CMA was found to permit rapid milk dose escalation in the majority of subjects..PubMedCrossRef • Nadeau KC, Schneider LC, Hoyte L, Borras I, Umetsu DT. Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy. J Allergy Clin Immunol. 2011;127(6):1622–4. Epub 2011/05/07. In this pilot phase I study, omalizumab treatment combined with oral milk desensitization in children with CMA was found to permit rapid milk dose escalation in the majority of subjects..PubMedCrossRef
86.
go back to reference Kalliomaki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet. 2001;357(9262):1076–9. Epub 2001/04/12.PubMedCrossRef Kalliomaki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet. 2001;357(9262):1076–9. Epub 2001/04/12.PubMedCrossRef
87.
go back to reference •• Kim JS, Nowak-Wegrzyn A, Sicherer SH, Noone S, Moshier EL, Sampson HA. Dietary baked milk accelerates the resolution of cow's milk allergy in children. J Allergy Clin Immunol. 128(1):125–31 e2. Epub 2011/05/24. This study demonstrated that the addition of baked milk to the diet of children who tolerated such foods may accelerate the development of unheated milk tolerance, as compared wilth those who avoided milk strictly. •• Kim JS, Nowak-Wegrzyn A, Sicherer SH, Noone S, Moshier EL, Sampson HA. Dietary baked milk accelerates the resolution of cow's milk allergy in children. J Allergy Clin Immunol. 128(1):125–31 e2. Epub 2011/05/24. This study demonstrated that the addition of baked milk to the diet of children who tolerated such foods may accelerate the development of unheated milk tolerance, as compared wilth those who avoided milk strictly.
88.
go back to reference Nowak-Wegrzyn A, Fiocchi A. Rare, medium, or well done? The effect of heating and food matrix on food protein allergenicity. Curr Opin Allergy Clin Immunol. 2009;9(3):234–7. Epub 2009/05/16.PubMedCrossRef Nowak-Wegrzyn A, Fiocchi A. Rare, medium, or well done? The effect of heating and food matrix on food protein allergenicity. Curr Opin Allergy Clin Immunol. 2009;9(3):234–7. Epub 2009/05/16.PubMedCrossRef
89.
go back to reference Thomas K, Herouet-Guicheney C, Ladics G, Bannon G, Cockburn A, Crevel R, et al. Evaluating the effect of food processing on the potential human allergenicity of novel proteins: international workshop report. Food Chem Toxicol. 2007;45(7):1116–22. Epub 2007/03/31.PubMedCrossRef Thomas K, Herouet-Guicheney C, Ladics G, Bannon G, Cockburn A, Crevel R, et al. Evaluating the effect of food processing on the potential human allergenicity of novel proteins: international workshop report. Food Chem Toxicol. 2007;45(7):1116–22. Epub 2007/03/31.PubMedCrossRef
90.
go back to reference Cooke SK, Sampson HA. Allergenic properties of ovomucoid in man. J Immunol. 1997;159(4):2026–32. Epub 1997/08/15.PubMed Cooke SK, Sampson HA. Allergenic properties of ovomucoid in man. J Immunol. 1997;159(4):2026–32. Epub 1997/08/15.PubMed
91.
go back to reference Jarvinen KM, Beyer K, Vila L, Bardina L, Mishoe M, Sampson HA. Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy. Allergy. 2007;62(7):758–65. Epub 2007/06/19.PubMedCrossRef Jarvinen KM, Beyer K, Vila L, Bardina L, Mishoe M, Sampson HA. Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy. Allergy. 2007;62(7):758–65. Epub 2007/06/19.PubMedCrossRef
92.
go back to reference Jarvinen KM, Chatchatee P, Bardina L, Beyer K, Sampson HA. IgE and IgG binding epitopes on alpha-lactalbumin and beta-lactoglobulin in cow's milk allergy. Int Arch Allergy Immunol. 2001;126(2):111–8. Epub 2001/12/01.PubMedCrossRef Jarvinen KM, Chatchatee P, Bardina L, Beyer K, Sampson HA. IgE and IgG binding epitopes on alpha-lactalbumin and beta-lactoglobulin in cow's milk allergy. Int Arch Allergy Immunol. 2001;126(2):111–8. Epub 2001/12/01.PubMedCrossRef
93.
go back to reference Wang J, Lin J, Bardina L, Goldis M, Nowak-Wegrzyn A, Shreffler WG, et al. Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. J Allergy Clin Immunol. 125(3):695–702, e1- e6. Epub 2010/03/17. Wang J, Lin J, Bardina L, Goldis M, Nowak-Wegrzyn A, Shreffler WG, et al. Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. J Allergy Clin Immunol. 125(3):695–702, e1- e6. Epub 2010/03/17.
94.
go back to reference Pelucchi C, Chatenoud L, Turati F, Galeone C, Moja L, Bach JF, et al. Probiotics supplementation during pregnancy or infancy for the prevention of atopic dermatitis: a meta-analysis. Epidemiology. 2012;23(3):402–14. Epub 2012/03/24.PubMedCrossRef Pelucchi C, Chatenoud L, Turati F, Galeone C, Moja L, Bach JF, et al. Probiotics supplementation during pregnancy or infancy for the prevention of atopic dermatitis: a meta-analysis. Epidemiology. 2012;23(3):402–14. Epub 2012/03/24.PubMedCrossRef
95.
go back to reference • Berni Canani R, Nocerino R, Terrin G, Coruzzo A, Cosenza L, Leone L, et al. Effect of Lactobacillus GG on tolerance acquisition in infants with cow's milk allergy: a randomized trial. J Allergy Clin Immunol. 2012;129(2):580–2. 2 e1-5. Epub 2011/11/15. This randomized study involving infants with strongly suspected cow’s milk allergy suggested that supplementation of extensively hydrolyzed casein formula with lactobacillus GG accelerates development of tolerance to cow's milk protein.PubMedCrossRef • Berni Canani R, Nocerino R, Terrin G, Coruzzo A, Cosenza L, Leone L, et al. Effect of Lactobacillus GG on tolerance acquisition in infants with cow's milk allergy: a randomized trial. J Allergy Clin Immunol. 2012;129(2):580–2. 2 e1-5. Epub 2011/11/15. This randomized study involving infants with strongly suspected cow’s milk allergy suggested that supplementation of extensively hydrolyzed casein formula with lactobacillus GG accelerates development of tolerance to cow's milk protein.PubMedCrossRef
96.
go back to reference • Savilahti EM, Viljanen M, Kuitunen M, Savilahti E. Cow's milk and ovalbumin-specific IgG and IgA in children with eczema: low beta-lactoglobulin-specific IgG4 levels are associated with cow's milk allergy. Pediatr Allergy Immunol: Off Publ Eur Soc Pediatr Allergy Immunol. 2012. Epub 2012/03/23. This study suggested that supplementation of extensively hydrolyzed casein formula with Lactobacillus GG accelerated the development of tolerance to cow’s milk in infants. • Savilahti EM, Viljanen M, Kuitunen M, Savilahti E. Cow's milk and ovalbumin-specific IgG and IgA in children with eczema: low beta-lactoglobulin-specific IgG4 levels are associated with cow's milk allergy. Pediatr Allergy Immunol: Off Publ Eur Soc Pediatr Allergy Immunol. 2012. Epub 2012/03/23. This study suggested that supplementation of extensively hydrolyzed casein formula with Lactobacillus GG accelerated the development of tolerance to cow’s milk in infants.
97.
go back to reference Karlsson MR, Rugtveit J, Brandtzaeg P. Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy. J Exp Med. 2004;199(12):1679–88. Epub 2004/06/16.PubMedCrossRef Karlsson MR, Rugtveit J, Brandtzaeg P. Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy. J Exp Med. 2004;199(12):1679–88. Epub 2004/06/16.PubMedCrossRef
Metadata
Title
IgE-Mediated Cow’s Milk Allergy in Children
Authors
Faith Huang
Jennifer S. Kim
Publication date
01-12-2012
Publisher
Current Science Inc.
Published in
Current Allergy and Asthma Reports / Issue 6/2012
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-012-0289-9

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