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Current Treatment Options in Oncology
Published in: Current Treatment Options in Oncology 6/2020

01-06-2020 | Lymphoma | Lymphoma (DO Persky, Section Editor)

PI3K Inhibitors and Their Role as Novel Agents for Targeted Therapy in Lymphoma

Authors: Vladimir Sapon-Cousineau, MD, Sasha Sapon-Cousineau, DEC, Sarit Assouline, MD, MSc

Published in: Current Treatment Options in Oncology | Issue 6/2020

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Opinion statement

Phosphatidylinositol 3-kinase (PI3K) inhibitors represent a novel class of agents targeting the key cellular regulatory PI3K/AKT/mTOR pathway involved in crucial functions such as cellular proliferation, cell cycle regulation, protein synthesis, and cell motility. This review starts with an overview of the PI3K pathway and the rationale for its targeting in lymphoma and potential on-target side effects of PI3K inhibition. With three agents now FDA approved for the treatment of relapsed and refractory (R/R) indolent non-Hodgkin lymphoma (iNHL), idelalisib, copanlisib, and duvelisib, we aim to review the pivotal trials leading to their approval as well as their clinical applications according to lymphoma subtypes. Important treatment-related adverse events are also reviewed and a perspective on the clinical role of these agents is provided, as well as some practical guidance on how to prevent, monitor, and manage potential adverse events in the clinic. PI3K inhibitors have an established role in the management of R/R iNHL, but their use and development are hampered by adverse events, particularly when used in combination with other anti-lymphoma therapies. Finally, this review highlights areas in need of more research in order to optimally use these agents in the care of patients with lymphoma.
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Metadata
Title
PI3K Inhibitors and Their Role as Novel Agents for Targeted Therapy in Lymphoma
Authors
Vladimir Sapon-Cousineau, MD
Sasha Sapon-Cousineau, DEC
Sarit Assouline, MD, MSc
Publication date
01-06-2020
Publisher
Springer US
Keyword
Lymphoma
Published in
Current Treatment Options in Oncology / Issue 6/2020
Print ISSN: 1527-2729
Electronic ISSN: 1534-6277
DOI
https://doi.org/10.1007/s11864-020-00746-8

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