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Current Treatment Options in Oncology
Published in: Current Treatment Options in Oncology 5/2017

01-05-2017 | Breast Cancer (ML Telli, Section Editor)

The Changing Landscape of Genetic Testing for Inherited Breast Cancer Predisposition

Authors: Anosheh Afghahi, MD, MPH, Allison W. Kurian, MD, MSc

Published in: Current Treatment Options in Oncology | Issue 5/2017

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Opinion statement

The advent of multiple-gene germline panel testing has led to significant advances in hereditary breast and ovarian cancer risk assessment. These include guideline-specific cancer risk management recommendations for patients and their families, such as screening with breast magnetic resonance imaging and risk-reducing surgeries, which have the potential to reduce substantially the morbidity and mortality associated with a hereditary cancer predisposition. However, controversy remains about the clinical validity and actionability of genetic testing in a broader patient population. We discuss events leading to the wider availability of commercialized multiple-gene germline panel testing, the recent data that support using this powerful tool to improve cancer risk assessment and reduction strategies, and remaining challenges to clinical optimization of this new genetic technology.
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Metadata
Title
The Changing Landscape of Genetic Testing for Inherited Breast Cancer Predisposition
Authors
Anosheh Afghahi, MD, MPH
Allison W. Kurian, MD, MSc
Publication date
01-05-2017
Publisher
Springer US
Published in
Current Treatment Options in Oncology / Issue 5/2017
Print ISSN: 1527-2729
Electronic ISSN: 1534-6277
DOI
https://doi.org/10.1007/s11864-017-0468-y

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