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Irish Journal of Medical Science (1971 -)
Published in: Irish Journal of Medical Science (1971 -) 6/2023

10-04-2023 | Metformin | Original Article

Liraglutide combined with metformin treatment for obese people with type 2 diabetes mellitus: a systematic review and meta-analysis

Authors: Yang Long, Yuxi Zhang

Published in: Irish Journal of Medical Science (1971 -) | Issue 6/2023

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Abstract

Aim

To assess clinical efficacy and safety of liraglutide combined with metformin (LMT) in obese patients with type 2 diabetes (ODP) by conducting a meta-analysis of randomized controlled trials (RCTs).

Methods

PubMed, EMBASE, Cochrane Library, CNKI, CNKI, and VIP databases were systematically searched for randomized controlled trials (RCTs) through January 1, 2015 to investigate the effectiveness of liraglutide combined with metformin treatment (LMT) in obesity patients with type 2 diabetes (ODP). Meta-analysis (using generic inverse variance random effects model) was performed when there were two or more studies reporting on the same evaluation indicators. Review Manager V.5.3 was used to perform the meta-analysis.

Results

A total of 1289 participants from 15 RCTs were selected for the final meta-analysis. A synthesis of current evidence of LMT for treating ODP was provided in this protocol.

Conclusion

This review will offer insights for future research and provide reference for LMT treatment for ODP.
Literature
1.
Jiang T, Zhang N, Zuo X, et al. (2017) Effects of exenatide on dietary habits in obese type 2 diabetic patients. Chin J Diabetes Mellitus 9:87–40
2.
Ji L, Liu J, Yang J, et al. (2019) Comparison of efficacy and safety of metformin XR to IR in the treatment of type 2 diabetes in north and south China. Chin J Diabetes Mellitus 27:369–374
3.
4.
Cao L, Song X, Feng K, et al. (2019) Effects of liraglutide intervention combined with PCI therapy on ventricular remodeling and cardiac function in patients with acute myocardial infarction and type 2 diabetes mellitus [J]. Chin J Endocrinol Metab Chin J Endocrinol Metab 35:121–127
5.
HuanXiong WuX, Guo X, et al. (2019) Practice of medication therapy management for a patient with obesity diabetes mellitus by clinical pharmacists. China Pharmacy 26:1830–1834
6.
D M, A L, J T, DG A, (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 339:b2535CrossRef
7.
Liu Z, Feng Q, Li L (2019) To explore the efficacy of Liraglutide combined with metformin in the treatment of type 2 diabetes mellitus with obesity (T2DM) patients. Straits Pharmacy 31:223–224
8.
Zhao X, Wang Q (2021) Clinical observation of lilalutide combined with metformin in the treatment of obese patients with newly diagnosed type 2 diabetes mellitus. China Pharmaceuticals 30:72–74
9.
10.
Song W (2016) Observation of clinical effoct of liraghutide combined with metformin in the treatment of patients with obesity type 2 diabetes. Drugs and Clinic 13:23–26
11.
Li W, Zhang Q, Yuan N, Chen H (2015) Clinical observation on liraglutide in treating early-onset T2DM of obstructive sleep apnea hypopnea syndrome complicating obesity. China Pharmaceuticals 24:58–60
12.
13.
Chen L (2016) Clinical curative effect of liraglutide combined with metformin in the treatment of obese patients with type 2 diabetes. Chinese Community Doctors 32:37+39
14.
Guo J (2018) Pharmacological characteristics and clinical application of Liraglutide in the treatment of obese type 2 diabetes mellitus Northern Chinese Pharmacy 15:75–75
15.
wang J, Lu Y, Wang H, Yang Y, (2021) Effects of liraglutide on fasting blood glucose, 2h postpranital blood glucose and glycosylated hemoglobin in patiengs with obese type2 diabetes mellitus. Hebei Medical Journal 43:897–900
16.
17.
Zheng H (2020) Pharmacological characteristics and clinical effects of Liraglutide in the treatment of obese type 2 diabetes mellitus Northern Pharmacy 17:121–122
18.
Huang H (2019) Efficacy of Liraglutide in the treatment of obese patients with type 2 diabetes. Journal of Heze Medical College 31:14–15+22
19.
Luo G, Liu J (2015) Efficacy of liraglutide combined with metformin in the treatment of newly diagnosed obese type 2 diabetes mellitus. Contemporary Medicine 21:121–122
20.
Yang D (2017) Clinical observation of liraglutide combined with metformin in the treatment of obese type 2 diabetes mellitus. Henan Medical Research 26:4475–4476
21.
Lin B, He M, Wang J (2020) Clinical observation of liraglutide combined with metformin in the treatment of newly diagnosed obese type 2 diabetes China Medicine and Pharmacy 10:78–81
22.
MO B, EM B, CT B, TVS D, PM H, CK R, KD R, AS K (2021) Effect of liraglutide treatment on body mass index and weight parameters in children and adolescents with type 2 diabetes: post hoc analysis of the ellipse trial. Pediatr Obes 16:e12778. https://​doi.​org/​10.​1111/​ijpo.​12778. Epub 2021 Feb 25. PMID: 33634589; PMCID: PMC8277686
23.
WT G, AL B, D D, G M, SD P, A S, D S, D S, C J, O M (2020) Efficacy and safety of liraglutide 3.0 mg in individuals with overweight or obesity and type 2 diabetes treated with basal insulin: the SCALE insulin randomized controlled trial. Diabetes Care 43:1085–1093. https://​doi.​org/​10.​2337/​dc19-1745
24.
Qiu H, Kong L, Ma L (2019) Clinical efficacy and safety evaluation of metformin combined with liraglutide in the treatment of obese type 2 diabetes. China Modern Doctor 57:98–101
25.
Huang H, Lai D, Zhou L, et al. (2020) Clinical efficacy of Liraglutide, lipliptin and metformin in the treatment of type 2 diabetes mellitus with non-alcoholic fatty liver disease. Chinese Modern Pharmaceutical Application 14:157–159
26.
Yan Y (2019) To observe the clinical effect of liraglutide combined with metformin in the treatment of type 2 diabetes. Chinese Journal of Modern Pharmaceutical Application 13:197–198
27.
Lao H (2021) Analysis of the efficacy and metabolic index of liraglutide combined with metformin in the treatment of obese type 2 diabetes. Diabetes New World 24(92–94):98
28.
Gong L (2021) Clinical efficacy of Liraglutide combined with metformin in the treatment of overweight/obese type 2 diabetes mellitus. Chin J of Clinical Rational Drug Use 14:68–70
29.
qingren N, Luo Q, (2021) Analysis the efficient of liraglutide combined with metformin in the treatment of obese Type 2 diabetes patients in plateau area. Qinghai Medical Journal 51:12–14
30.
Wu Y, Liu J, Yang Y (2021) Comparative study on dulaglutide and liraglutide combined with metformin in treatment of overweight and obesity type 2 diabetes mellitus. Drugs & Clinic 36:957–960
Metadata
Title
Liraglutide combined with metformin treatment for obese people with type 2 diabetes mellitus: a systematic review and meta-analysis
Authors
Yang Long
Yuxi Zhang
Publication date
10-04-2023
Publisher
Springer International Publishing
Published in
Irish Journal of Medical Science (1971 -) / Issue 6/2023
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI
https://doi.org/10.1007/s11845-023-03337-2

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