Skip to main content
Top
Published in: Irish Journal of Medical Science (1971 -) 4/2020

01-11-2020 | Acute Kidney Injury | Review Article

COVID-19 in adults: test menu for hospital blood science laboratories

Authors: Paula M. O’Shea, Graham Robert Lee, Tomás P. Griffin, Vincent Tormey, Amjad Hayat, Seán J. Costelloe, Damian Gerard Griffin, Saradha Srinivasan, Maurice O’Kane, Conor M. Burke, John Faul, Christopher J. Thompson, Gerard Curley, William P. Tormey

Published in: Irish Journal of Medical Science (1971 -) | Issue 4/2020

Login to get access

Abstract

Introduction

Coronavirus disease 2019 (COVID-19), is a respiratory illness caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The Clinical Blood Sciences Laboratory (CBSL) plays a key role in supporting the monitoring and management of patients with COVID-19 disease.

Objective

To provide a comprehensive CBSL testing protocol to support the medical management of SARS-CoV-2 infection.

Methods

Description of the biochemical, haematological and immunological tests that have a role in the assessment and monitoring of patients with COVID-19 infection.

Results

We provide a test menu for clinical laboratories to ensure the effective monitoring, management and prognostication of COVID-19 patients in hospital.

Conclusion

Given the rapidity with which patients with COVID-19 disease can deteriorate, we recommend regular testing with vigilance paid to the rate and trajectory of change in each of these parameters.
Literature
3.
go back to reference Mehta P, McAuley DF, Brown M et al (2020) COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 395:1033–1034CrossRef Mehta P, McAuley DF, Brown M et al (2020) COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 395:1033–1034CrossRef
5.
go back to reference Lippi G, Plebani M (2020) Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chim Acta 505:190–191CrossRef Lippi G, Plebani M (2020) Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chim Acta 505:190–191CrossRef
8.
go back to reference Guan WJ, Ni ZY, Hu Y, China Medical Treatment Expert Group for Covid-19 et al (2020) Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 382:1708–1720CrossRef Guan WJ, Ni ZY, Hu Y, China Medical Treatment Expert Group for Covid-19 et al (2020) Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 382:1708–1720CrossRef
9.
go back to reference Huang C, Wang Y, Li X et al (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395:497–506CrossRef Huang C, Wang Y, Li X et al (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395:497–506CrossRef
11.
go back to reference Hamming I, Timens W, Bulthuis ML et al (2004) Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 203:631–637CrossRef Hamming I, Timens W, Bulthuis ML et al (2004) Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 203:631–637CrossRef
12.
go back to reference Vaduganathan M, Vardeny O, Michel T et al (2020) Renin-angiotensin-aldosterone system inhibitors in patients with Covid-19. N Engl J Med 382:1653–1659CrossRef Vaduganathan M, Vardeny O, Michel T et al (2020) Renin-angiotensin-aldosterone system inhibitors in patients with Covid-19. N Engl J Med 382:1653–1659CrossRef
13.
go back to reference Zhou F, Yu T, Du R et al (2020) Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395:1054–1062CrossRef Zhou F, Yu T, Du R et al (2020) Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395:1054–1062CrossRef
14.
go back to reference Cheng Y, Luo R, Wang K et al (2020) Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int 97:829–838CrossRef Cheng Y, Luo R, Wang K et al (2020) Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int 97:829–838CrossRef
15.
go back to reference Levey AS, Stevens LA, Schmid CH et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150:604–612CrossRef Levey AS, Stevens LA, Schmid CH et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150:604–612CrossRef
16.
go back to reference Simmons J, Pittet JF (2015) The coagulopathy of acute sepsis. Curr Opin Anaesthesiol 28:227–236CrossRef Simmons J, Pittet JF (2015) The coagulopathy of acute sepsis. Curr Opin Anaesthesiol 28:227–236CrossRef
18.
go back to reference Kwong JC, Schwartz KL, Campitelli MA et al (2018) Acute myocardial infarction after laboratory-confirmed influenza infection. N Engl J Med 378:345–353CrossRef Kwong JC, Schwartz KL, Campitelli MA et al (2018) Acute myocardial infarction after laboratory-confirmed influenza infection. N Engl J Med 378:345–353CrossRef
19.
go back to reference Nguyen JL, Yang W, Ito K et al (2016) Seasonal influenza infections and cardiovascular disease mortality. JAMA Cardiol 1:274–281CrossRef Nguyen JL, Yang W, Ito K et al (2016) Seasonal influenza infections and cardiovascular disease mortality. JAMA Cardiol 1:274–281CrossRef
20.
go back to reference Smeeth L, Thomas SL, Hall AJ et al (2004) Risk of myocardial infarction and stroke after acute infection or vaccination. N Engl J Med 351:2611–2618CrossRef Smeeth L, Thomas SL, Hall AJ et al (2004) Risk of myocardial infarction and stroke after acute infection or vaccination. N Engl J Med 351:2611–2618CrossRef
27.
go back to reference Vankadari N, Wilce JA (2020) Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26. Emerg Microbes Infect 9:601–604CrossRef Vankadari N, Wilce JA (2020) Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26. Emerg Microbes Infect 9:601–604CrossRef
28.
go back to reference Komolmit P, Charoensuk K, Thanapirom K et al (2017) Correction of vitamin D deficiency facilitated suppression of IP-10 and DPP IV levels in patients with chronic hepatitis C: a randomised double-blinded, placebo-control trial. PLoS One 12:e0174608CrossRef Komolmit P, Charoensuk K, Thanapirom K et al (2017) Correction of vitamin D deficiency facilitated suppression of IP-10 and DPP IV levels in patients with chronic hepatitis C: a randomised double-blinded, placebo-control trial. PLoS One 12:e0174608CrossRef
29.
go back to reference Sadeghi K, Wessner B, Laggner U et al (2006) Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immunol 36:361–370CrossRef Sadeghi K, Wessner B, Laggner U et al (2006) Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immunol 36:361–370CrossRef
30.
go back to reference McCartney DM, Byrne DG (2020) Optimisation of vitamin D status for enhanced immuno-protection against Covid-19. Ir Med J 113:58PubMed McCartney DM, Byrne DG (2020) Optimisation of vitamin D status for enhanced immuno-protection against Covid-19. Ir Med J 113:58PubMed
Metadata
Title
COVID-19 in adults: test menu for hospital blood science laboratories
Authors
Paula M. O’Shea
Graham Robert Lee
Tomás P. Griffin
Vincent Tormey
Amjad Hayat
Seán J. Costelloe
Damian Gerard Griffin
Saradha Srinivasan
Maurice O’Kane
Conor M. Burke
John Faul
Christopher J. Thompson
Gerard Curley
William P. Tormey
Publication date
01-11-2020
Publisher
Springer London
Published in
Irish Journal of Medical Science (1971 -) / Issue 4/2020
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI
https://doi.org/10.1007/s11845-020-02252-0

Other articles of this Issue 4/2020

Irish Journal of Medical Science (1971 -) 4/2020 Go to the issue