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Irish Journal of Medical Science (1971 -)

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Open Access 01-08-2018 | Original Article

Cerebrospinal fluid and serum IL-8, CCL2, and ICAM-1 concentrations in astrocytic brain tumor patients

Authors: O. M. Koper, J. Kamińska, K. Sawicki, J. Reszeć, R. Rutkowski, M. Jadeszko, Z. Mariak, V. Dymicka-Piekarska, H. Kemona

Published in: Irish Journal of Medical Science (1971 -) | Issue 3/2018

Abstract

Background

The aim of the study was the evaluation of serum and CSF concentrations of CCL2, IL-8, and sICAM-1 in patients with astrocytic tumors as compared to a group of non-tumoral patients.

Methods

Chemokine concentrations were measured using the ELISA method.

Results

Regardless of the parameter tested and the patient group (brain tumor or non-tumoral patients), statistical differences (P < 0.05) were found between concentrations obtained in CSF compared to values obtained in serum for all proteins tested. CSF IL-8 concentrations were significantly elevated in CNS tumor patients as compared to non-tumoral individuals (P = 0.000); serum CCL2 and sICAM-1 concentrations were significantly decreased in CNS tumors in comparison with the comparative group (P = 0.002 and P = 0.026, respectively). Among proteins tested in the serum, a higher area under the ROC curve (AUC) revealed CCL2 compared to sICAM-1 in differentiating subjects with CNS brain tumors from non-tumoral subjects. AUC for CSF IL-8 was higher than for its index (CSF IL-8/serum IL-8).

Conclusions

For individual biomarkers (IL-8 and CCL2, sICAM-1), measured in CNS brain tumor patients, the appropriate material, respectively CSF or serum, should be chosen and quantitatively tested. Increased cerebrospinal fluid IL-8 with decreased serum CCL2 create a pattern of biomarkers, which may be helpful in the management of CNS astrocytic brain tumors.

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Title: Cerebrospinal fluid and serum IL-8, CCL2, and ICAM-1 concentrations in astrocytic brain tumor patients
Authors: O. M. Koper
J. Kamińska
K. Sawicki
J. Reszeć
R. Rutkowski
M. Jadeszko
Z. Mariak
V. Dymicka-Piekarska
H. Kemona
Publication date: 01-08-2018
Publisher: Springer London
Published in: Irish Journal of Medical Science (1971 -) / Issue 3/2018
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI: https://doi.org/10.1007/s11845-017-1695-8

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Background

Methods

Results

Conclusions

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