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Irish Journal of Medical Science (1971 -)

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Open Access 01-08-2018 | Original Article

Long non-coding RNA TRPM2-AS as a potential biomarker for hepatocellular carcinoma

Authors: C. Xu, Q. Huang, C. Zhang, W. Xu, G. Xu, X. Zhao, X. Liu, Y. Du

Published in: Irish Journal of Medical Science (1971 -) | Issue 3/2018

Abstract

Background

There is increasing evidence that long non-coding RNAs are involved in hepatocellular carcinoma (HCC) tumorigenesis. The expression level of TRPM2-AS in HCC and its clinical association remain poorly defined.

Method

qRT-PCR was performed to detect the expression of TRPM2-AS in 108 HCC patients. The correlations between TRPM2-AS expression and clinicopathological factors and prognosis were evaluated. The inference of TRPM2-AS to the proliferation and apoptosis of HCC cells was detected.

Aims

The aim of our study was to explore the expression of TRPM2-AS in hepatocellular carcinoma (HCC) and the relation with prognosis and clinical features.

Results

The expression of TRPM2-AS was higher in most HCC tissues and was significantly correlated with tumor size, AJCC stage, tumor differentiation, and the prognosis of HCC patients. Interfering TRPM2-AS expression using siRNA significantly inhibited cell proliferation and promoted cell apoptosis in two HCC cell lines.

Conclusion

Long non-coding RNA TRPM2-AS is upregulated in HCC and represents a new biomarker for HCC and the inhibition of TRPM2-AS promotes apoptosis in HCC cells in vitro.

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Title: Long non-coding RNA TRPM2-AS as a potential biomarker for hepatocellular carcinoma
Authors: C. Xu
Q. Huang
C. Zhang
W. Xu
G. Xu
X. Zhao
X. Liu
Y. Du
Publication date: 01-08-2018
Publisher: Springer London
Published in: Irish Journal of Medical Science (1971 -) / Issue 3/2018
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI: https://doi.org/10.1007/s11845-017-1692-y

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Long non-coding RNA TRPM2-AS as a potential biomarker for hepatocellular carcinoma

Abstract

Background

Method

Aims

Results

Conclusion

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Abstract

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Conclusion

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