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Irish Journal of Medical Science (1971 -)

Published in:

01-08-2017 | Original Article

Obstetric outcomes of recurrent pregnancy loss patients diagnosed wıth inherited thrombophilia

Authors: C. Karadağ, T. Yoldemir, S. D. Karadağ, C. İnan, Z. N. Dolgun, L. Aslanova

Published in: Irish Journal of Medical Science (1971 -) | Issue 3/2017

Abstract

Background

Recurrent pregnancy loss (RPL) is defined by two or more failed pregnancies. The relation between RPL and inherited thrombophilia requires anticoagulant therapy during pregnancy. However the obstetric outcomes have not been well defined in these RPL patients diagnosed with inherited thrombophilia, who have been given anticoagulant therapy.

Aim

To investigate the obstetric outcomes in pregnant women with RPL who are given low molecular weight heparin (LMWH) and low-dose aspirin due to diagnosis of inherited thrombophilia.

Methods

A hundred and eight RPL women were diagnosed with inherited thrombophilia, and 98 women were diagnosed with unexplained RPL. The patients with inherited thrombophilia were given LMWH and low-dose aspirin. Unexplained RPL patients were not given any medicine. The obstetric outcomes of participants were noted.

Results

In thrombophilic group, the live-birth levels were significantly higher [90 (83%) vs 67 (68%) p < 0.05], and the miscarriage levels were significantly lower than that in the control group [14 (13%) vs 27 (28%) p < 0.01]. The number of patients with preeclampsia was significantly higher in the thrombophilic group [16 (15%) vs 6 (6%) p < 0.05]. The number of preterm births was significantly higher than that of the controls [25 (23%) vs 10 (10%) p < 0.05]. The median gestation age of delivery was 35 weeks for thrombophilic patients and 38 weeks for controls (p < 0.05).

Conclusion

The RPL patients diagnosed with inherited thrombophilia and who were given LMWH with low-dose aspirin had higher live-birth rates and lower miscarriage rates than those in the unexplained RPL patients. Increased risk of preeclampsia is seen in RPL patients with inherited thrombophilia despite thrombophilia prophylaxis.

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Title: Obstetric outcomes of recurrent pregnancy loss patients diagnosed wıth inherited thrombophilia
Authors: C. Karadağ
T. Yoldemir
S. D. Karadağ
C. İnan
Z. N. Dolgun
L. Aslanova
Publication date: 01-08-2017
Publisher: Springer London
Published in: Irish Journal of Medical Science (1971 -) / Issue 3/2017
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI: https://doi.org/10.1007/s11845-017-1569-0

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