Skip to main content
Top
Published in: Irish Journal of Medical Science (1971 -) 2/2012

01-06-2012 | Original Article

A budget impact analysis of natalizumab use in Ireland

Authors: A. Dee, M. Hutchinson, D. De La Harpe

Published in: Irish Journal of Medical Science (1971 -) | Issue 2/2012

Login to get access

Abstract

Background

Multiple sclerosis is the commonest cause of disability in young Irish adults. Natalizumab reduces disability progression in those patients with relapsing remitting multiple sclerosis who are suitable for it. First line disease modifying therapies are given in the community and are paid for by the hi-tech drug scheme. Natalizumab is given in hospital and is paid for from the hospital’s budget. Access to natalizumab has been problematic in some Irish hospitals. A budget impact analysis was performed to look at the overall cost to the Health Service Executive of giving natalizumab.

Methods

A budget impact analysis was performed from the perspective of the Health Service Executive comparing the use of natalizumab with first line disease modifying therapies for 2009–2011.

Results

The study showed that currently, the use of natalizumab is likely to be cost saving to the Health Service Executive overall, because some of the costs for natalizumab are borne by private insurers, whereas, all of the costs of disease modifying therapies are borne by the Health Service Executive.

Conclusions

Although the use of natalizumab is cost saving, current funding arrangements in the Health Service Executive do not allow for the transfer of money saved from drugs paid for in the hi-tech scheme, to hospitals who are supplying alternative treatments.
Footnotes
1
Health Atlas Ireland is a collaboration of Population Health, HSE (Health Intelligence and HPSC), the School of Public Health and Population Sciences UCD and Dept of Geography, NUI, Maynooth providing access to “health mapping” across a sector through integrating geographical information systems, health datasets and statistical techniques. Funded by the Health Research Board and HPSC, it uses geocoded data from the Census, HIPE, mortality, infectious disease notifications, cancer registration, prescribing, disability and environmental data.
 
Literature
1.
go back to reference McGuigan C, McCarthy A, Quigley C, Bannan L, Hawkins S, Hutchinson M (2004) Latitudinal variation in the prevalence of multiple sclerosis in Ireland, an effect of genetic diversity. J Neurol Neurosurg Psychiatry 75(4):572–576PubMedCrossRef McGuigan C, McCarthy A, Quigley C, Bannan L, Hawkins S, Hutchinson M (2004) Latitudinal variation in the prevalence of multiple sclerosis in Ireland, an effect of genetic diversity. J Neurol Neurosurg Psychiatry 75(4):572–576PubMedCrossRef
2.
go back to reference McDonnell G, Hawkins S (1998) An epidemiologic study of multiple sclerosis in Northern Ireland. Neurology 50(2):423–428PubMed McDonnell G, Hawkins S (1998) An epidemiologic study of multiple sclerosis in Northern Ireland. Neurology 50(2):423–428PubMed
3.
go back to reference McGuigan C, Dunne C, Crowley J, Hagan R, Rooney G, Lawlor E et al (2005) Population frequency of HLA haplotypes contributes to the prevalence difference of multiple sclerosis in Ireland. J. Neurol 252(10):1245–1248CrossRef McGuigan C, Dunne C, Crowley J, Hagan R, Rooney G, Lawlor E et al (2005) Population frequency of HLA haplotypes contributes to the prevalence difference of multiple sclerosis in Ireland. J. Neurol 252(10):1245–1248CrossRef
4.
go back to reference Central Statistics Office, Cork (2008) Regional population projections 2011–2026 Central Statistics Office, Cork (2008) Regional population projections 2011–2026
5.
go back to reference Gray OM, McDonnell GV, Hawkins SA (2008) Factors in the rising prevalence of multiple sclerosis in the north-east of Ireland. Mult Scler 14(7):880–886PubMedCrossRef Gray OM, McDonnell GV, Hawkins SA (2008) Factors in the rising prevalence of multiple sclerosis in the north-east of Ireland. Mult Scler 14(7):880–886PubMedCrossRef
6.
go back to reference Mauskopf J, Sullivan S, Annemans L, Caro J, Mullins C, Nuijten M et al (2007) Principles of good practice for budget impact analysis: report of the ISPOR task force on good research practices-budget impact analysis. Value Health 10(5):336–347PubMedCrossRef Mauskopf J, Sullivan S, Annemans L, Caro J, Mullins C, Nuijten M et al (2007) Principles of good practice for budget impact analysis: report of the ISPOR task force on good research practices-budget impact analysis. Value Health 10(5):336–347PubMedCrossRef
7.
go back to reference Orlewska E, Mierzejewski P (2004) Proposal of Polish guidelines for conducting financial analysis and their comparison to existing guidance on budget impact in other countries. Value Health 7(1):1–10PubMedCrossRef Orlewska E, Mierzejewski P (2004) Proposal of Polish guidelines for conducting financial analysis and their comparison to existing guidance on budget impact in other countries. Value Health 7(1):1–10PubMedCrossRef
8.
go back to reference Oturia A, Koch-Henriksen N, Petersen T, Jensen P, Sellebjerg F, Sorensen P (2009) Efficacy of natalizumab in multiple sclerosis patients with high disease activity: a Danish nationwide study. Eur J Neurol 16:420–423CrossRef Oturia A, Koch-Henriksen N, Petersen T, Jensen P, Sellebjerg F, Sorensen P (2009) Efficacy of natalizumab in multiple sclerosis patients with high disease activity: a Danish nationwide study. Eur J Neurol 16:420–423CrossRef
9.
go back to reference Putzki N, Kollia K, Woods S, Igwe E, Diener H, Limmroth V (2009) Natalizumab is effective as second line therapy in the treatment of relapsing remitting multiple sclerosis. Eur J Neurol 16:424–426PubMedCrossRef Putzki N, Kollia K, Woods S, Igwe E, Diener H, Limmroth V (2009) Natalizumab is effective as second line therapy in the treatment of relapsing remitting multiple sclerosis. Eur J Neurol 16:424–426PubMedCrossRef
10.
go back to reference Health Service Executive, Dublin (2007) Report on neurology and neurophysiology services. (Unpublished) Health Service Executive, Dublin (2007) Report on neurology and neurophysiology services. (Unpublished)
11.
go back to reference National Centre for Pharmacoeconomics, Dublin (2007) Economic evaluation of natalizumab (Tysabri) for the treatment of relapsing remitting multiple sclerosis that is rapidly evolving and severe or sub-optimally treated National Centre for Pharmacoeconomics, Dublin (2007) Economic evaluation of natalizumab (Tysabri) for the treatment of relapsing remitting multiple sclerosis that is rapidly evolving and severe or sub-optimally treated
12.
go back to reference Tappenden P, McCabe C, Chilcott J, Simpson E, Nixon R, Madan J et al (2009) Cost-effectiveness of disease-modifying therapies in the management of multiple sclerosis for the medicare population. Value Health 12(5):657–665PubMedCrossRef Tappenden P, McCabe C, Chilcott J, Simpson E, Nixon R, Madan J et al (2009) Cost-effectiveness of disease-modifying therapies in the management of multiple sclerosis for the medicare population. Value Health 12(5):657–665PubMedCrossRef
Metadata
Title
A budget impact analysis of natalizumab use in Ireland
Authors
A. Dee
M. Hutchinson
D. De La Harpe
Publication date
01-06-2012
Publisher
Springer-Verlag
Published in
Irish Journal of Medical Science (1971 -) / Issue 2/2012
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI
https://doi.org/10.1007/s11845-011-0773-6

Other articles of this Issue 2/2012

Irish Journal of Medical Science (1971 -) 2/2012 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.