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Irish Journal of Medical Science (1971 -)

Published in:

01-12-2011 | Original Article

Coagulation and prothrombotic state parameters: a clinical analysis during early pregnancy

Authors: H. Chen, L. Zhou, L. Meng, M. Liu, J. Tan, L. Gao, J. Zhang

Published in: Irish Journal of Medical Science (1971 -) | Issue 4/2011

Abstract

Aim

The aim of this study is to assess the changes in coagulation, thrombosis, anticoagulation, and fibrinolysis during early pregnancy.

Methods

One hundred and five pregnant women with monozygotic pregnancies between 10 and 12 weeks gestation were randomly enrolled as the study group, and another 82 non-pregnant women were selected as the control group. Coagulation parameters and prothrombotic state parameters were measured.

Results

Fg, F1 + 2, thrombin–antithrombin complex, GMP140, D-dimer, and plasminogen activator inhibitor 2 were statistically different between the study and the control groups (p < 0.008). The coagulation, fibrinolytic, and the antifibrinolytic functions of healthy pregnant women are enhanced during early pregnancy, whereas the anticoagulation is slightly increased.

Conclusion

Coagulation, fibrinolysis, and antifibrinolysis remain at high levels, whereas the platelet activation remains at low levels during early pregnancy.

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Title: Coagulation and prothrombotic state parameters: a clinical analysis during early pregnancy
Authors: H. Chen
L. Zhou
L. Meng
M. Liu
J. Tan
L. Gao
J. Zhang
Publication date: 01-12-2011
Publisher: Springer-Verlag
Published in: Irish Journal of Medical Science (1971 -) / Issue 4/2011
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI: https://doi.org/10.1007/s11845-011-0737-x

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