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Irish Journal of Medical Science (1971 -)
Published in: Irish Journal of Medical Science (1971 -) 3/2011

01-09-2011 | Case Report

Unusual presentation of gastrointestinal stromal tumor with early cerebral involvement

Authors: Filip Janku, David Kidney, John Coyne

Published in: Irish Journal of Medical Science (1971 -) | Issue 3/2011

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Abstract

Gastrointestinal stromal tumor (GIST) is a rare tumor typically arising from gastrointestinal tract. GIST very rarely metastasizes beyond abdominal cavity. Metastatic spread to the brain is anecdotal. This is a case study describing metastatic GIST with early cerebral involvement and resistance to therapy with KIT tyrosine kinase inhibitor imatinib mesylate.
Literature
1.
Nilsson B, Bümming P, Meis-Kindblom JM et al (2005) Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era-a population-based study in western Sweden. Cancer 103(4):821–829. doi:10.​1002/​cncr.​20862 PubMedCrossRef
2.
3.
4.
Brooks BJ, Bani JC, Fletcher CD et al (2002) Challenges in oncology Case 4. Response of metastatic gastrointestinal stromal tumor including CNS involvement to imatinib mesylate (STI-571). J Clin Oncol 20(3):870–872PubMed
5.
Takayama N, Sato N, O’Brien SG et al (2002) Imatinib mesylate has limited activity against the central nervous system involvement of Philadelphia chromosome-positive acute lymphoblastic leukaemia due to poor penetration into cerebrospinal fluid. Br J Haematol 119(1):106–108. doi:10.​1046/​j.​1365-2141.​2002.​03881.​x PubMedCrossRef
Metadata
Title
Unusual presentation of gastrointestinal stromal tumor with early cerebral involvement
Authors
Filip Janku
David Kidney
John Coyne
Publication date
01-09-2011
Publisher
Springer-Verlag
Published in
Irish Journal of Medical Science (1971 -) / Issue 3/2011
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI
https://doi.org/10.1007/s11845-010-0591-2

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