Skip to main content
Top
Published in: Journal of Cancer Survivorship 4/2011

01-12-2011

Cost-related medication nonadherence and cost-saving strategies used by elderly Medicare cancer survivors

Authors: Larissa Nekhlyudov, Jeanne Madden, Amy Johnson Graves, Fang Zhang, Stephen B. Soumerai, Dennis Ross-Degnan

Published in: Journal of Cancer Survivorship | Issue 4/2011

Login to get access

Abstract

Objectives

This study was conducted to compare cost-related medication nonadherence among elderly Medicare enrollees with and without cancer and to describe the strategies cancer survivors used to offset the costs of medications.

Methods

Using the 2005 Medicare Current Beneficiary Survey and Medicare claims, we compared self-reported cost-related medication nonadherence (CRN), spending less on basic needs to afford medicines, and cost reduction strategies among elderly beneficiaries with and without cancer. Descriptive statistics and logistic regression models were used to characterize and compare these populations.

Results

In a nationally representative sample of 9,818 non-institutionalized elderly Medicare enrollees, 1,392 (14%) were classified as cancer survivors based on Medicare claims. Cancer survivors were older, more highly educated, more likely to be male and non-Hispanic, and more likely to have multiple comorbidities, poorer health status, and employer-paid medication coverage. While 10% of cancer survivors and 11% without cancer reported CRN, about 6% and 9% (p = 0.004) of those with and without cancer, respectively, reported spending less on basic needs to offset the costs of medications. Cancer survivors who reported CRN (n = 143) had lower income (62.2% versus 48.6%, p = 0.11) and were more likely to be African-American (13.0% versus 6.4%, p = 0.033) and have non-employer-based medication insurance (p = 0.002) compared to those who did not report CRN. In adjusted analyses, CRN among the two groups was similar, but with some subgroup differences noted by gender and cancer type. Use of cost reduction strategies was mostly similar among cancer survivors and those without cancer.

Conclusion

Cost-related medication nonadherence medication is common among elderly Medicare beneficiaries, but appears to be similar among those with and without cancer.
Literature
1.
go back to reference Madden JM, Graves AJ, Zhang F, Adams AS, Briesacher BA, Ross-Degnan D, et al. Cost-related medication nonadherence and spending on basic needs following implementation of Medicare Part D. JAMA. 2008;299:1922–8.PubMedCrossRef Madden JM, Graves AJ, Zhang F, Adams AS, Briesacher BA, Ross-Degnan D, et al. Cost-related medication nonadherence and spending on basic needs following implementation of Medicare Part D. JAMA. 2008;299:1922–8.PubMedCrossRef
2.
go back to reference Piette JD, Heisler M, Wagner TH. Problems paying out-of-pocket medication costs among older adults with diabetes. Diabetes Care. 2004;27:384–91.PubMedCrossRef Piette JD, Heisler M, Wagner TH. Problems paying out-of-pocket medication costs among older adults with diabetes. Diabetes Care. 2004;27:384–91.PubMedCrossRef
3.
go back to reference Piette JD, Wagner TH, Potter MB, Schillinger D. Health insurance status, cost-related medication underuse, and outcomes among diabetes patients in three systems of care. Med Care. 2004;42:102–9.PubMedCrossRef Piette JD, Wagner TH, Potter MB, Schillinger D. Health insurance status, cost-related medication underuse, and outcomes among diabetes patients in three systems of care. Med Care. 2004;42:102–9.PubMedCrossRef
4.
go back to reference Tamblyn R, Laprise R, Hanley JA, Abrahamowicz M, Scott S, Mayo N, et al. Adverse events associated with prescription drug cost-sharing among poor and elderly persons. JAMA. 2001;285:421–9.PubMedCrossRef Tamblyn R, Laprise R, Hanley JA, Abrahamowicz M, Scott S, Mayo N, et al. Adverse events associated with prescription drug cost-sharing among poor and elderly persons. JAMA. 2001;285:421–9.PubMedCrossRef
5.
go back to reference Brown ML, Riley GF, Schussler N, Elzioni R. Estimating health care costs related to cancer treatment from SEER-Medicare data. Med Care. 2002;40(Supplemental IV):104–17. Brown ML, Riley GF, Schussler N, Elzioni R. Estimating health care costs related to cancer treatment from SEER-Medicare data. Med Care. 2002;40(Supplemental IV):104–17.
6.
go back to reference Chang S, Long SR, Kutikova L, Bowman L, Finley D, Crown WH, et al. Estimating the cost of cancer: results on the basis of claims data analyses for cancer patients diagnosed with seven types of cancer during 1999 to 2000. J Clin Oncol. 2004;22:3524–30.PubMedCrossRef Chang S, Long SR, Kutikova L, Bowman L, Finley D, Crown WH, et al. Estimating the cost of cancer: results on the basis of claims data analyses for cancer patients diagnosed with seven types of cancer during 1999 to 2000. J Clin Oncol. 2004;22:3524–30.PubMedCrossRef
7.
go back to reference Meropol NJ, Schulman KA. Cost of cancer care: issues and implications. J Clin Oncol. 2007;25:180–6.PubMedCrossRef Meropol NJ, Schulman KA. Cost of cancer care: issues and implications. J Clin Oncol. 2007;25:180–6.PubMedCrossRef
8.
go back to reference Langa KM, Fendrick AM, Chernew ME, Kabeto M, Paisley KL, Hayman JA. Out-of-pocket health-care expenditures among older Americans with cancer. Value Health. 2004;7:186–94.PubMedCrossRef Langa KM, Fendrick AM, Chernew ME, Kabeto M, Paisley KL, Hayman JA. Out-of-pocket health-care expenditures among older Americans with cancer. Value Health. 2004;7:186–94.PubMedCrossRef
9.
go back to reference The USA Today/Kaiser Family Foundation/Harvard School of Public Health. National survey of households affected by cancer. Menlo Park: The Henry J. Kaiser Family Foundation; 2006. The USA Today/Kaiser Family Foundation/Harvard School of Public Health. National survey of households affected by cancer. Menlo Park: The Henry J. Kaiser Family Foundation; 2006.
10.
go back to reference Himmelstein DU, Warren E, Thorne D, Woolhandler S. Illness and injury as contributors to bankruptcy. Health Affairs 2005;Suppl W5:63–73. Himmelstein DU, Warren E, Thorne D, Woolhandler S. Illness and injury as contributors to bankruptcy. Health Affairs 2005;Suppl W5:63–73.
11.
go back to reference Institute of Medicine and National Research Council of the National Academies. From cancer patient to cancer survivor: lost in transition. Washington: The National Academies; 2006. Institute of Medicine and National Research Council of the National Academies. From cancer patient to cancer survivor: lost in transition. Washington: The National Academies; 2006.
12.
go back to reference Weaver KE, Rowland JH, Bellizzi KM, Aziz NM. Forgoing medical care because of cost. Assessing disparities in healthcare access among cancer survivors living in the United States. Cancer. 2010;116:3493–504.PubMedCrossRef Weaver KE, Rowland JH, Bellizzi KM, Aziz NM. Forgoing medical care because of cost. Assessing disparities in healthcare access among cancer survivors living in the United States. Cancer. 2010;116:3493–504.PubMedCrossRef
13.
go back to reference Pierre-Jacques M, Safran DG, Zhang F, Ross-Degnan D, Adams AS, Gurwitz J, et al. Reliability of new measures of cost related medication nonadherence. Med Care. 2008;46:444–8.PubMedCrossRef Pierre-Jacques M, Safran DG, Zhang F, Ross-Degnan D, Adams AS, Gurwitz J, et al. Reliability of new measures of cost related medication nonadherence. Med Care. 2008;46:444–8.PubMedCrossRef
14.
go back to reference Bambauer KZ, Safran DG, Ross-Degnan D, Zhang F, Adams AS, Gurwitz J, et al. Depression and cost-related medication nonadherence in Medicare beneficiaries. Arch Gen Psych. 2007;64:602–8.CrossRef Bambauer KZ, Safran DG, Ross-Degnan D, Zhang F, Adams AS, Gurwitz J, et al. Depression and cost-related medication nonadherence in Medicare beneficiaries. Arch Gen Psych. 2007;64:602–8.CrossRef
15.
go back to reference Soumerai SB, Pierre-Jacques M, Ross-Degnan D, Adams AS, Gurwitz JH. Cost-related medication non-adherence among the elderly and the disabled: a national survey one year before the Medicare drug benefit. Arch Intern Med. 2006;166:1829–35.PubMedCrossRef Soumerai SB, Pierre-Jacques M, Ross-Degnan D, Adams AS, Gurwitz JH. Cost-related medication non-adherence among the elderly and the disabled: a national survey one year before the Medicare drug benefit. Arch Intern Med. 2006;166:1829–35.PubMedCrossRef
16.
go back to reference Tjia J, Briesacher BA, Soumerai SB, Pierre-Jacques M, Zhang F, Ross-Degnan D, et al. Medicare beneficiaries and free prescription drug samples: a national survey. J Gen Intern Med. 2008;23:709–14.PubMedCrossRef Tjia J, Briesacher BA, Soumerai SB, Pierre-Jacques M, Zhang F, Ross-Degnan D, et al. Medicare beneficiaries and free prescription drug samples: a national survey. J Gen Intern Med. 2008;23:709–14.PubMedCrossRef
17.
go back to reference Yabroff KR, Warren JL, Banthin J, Schrag D, Mariotto A, Lawrence W, et al. Comparison of approaches for estimating prevalence costs of care for cancer patients: what is the impact of data source? Med Care. 2009;47(Suppl):S64–9.PubMedCrossRef Yabroff KR, Warren JL, Banthin J, Schrag D, Mariotto A, Lawrence W, et al. Comparison of approaches for estimating prevalence costs of care for cancer patients: what is the impact of data source? Med Care. 2009;47(Suppl):S64–9.PubMedCrossRef
18.
go back to reference Mohile SG, Xian Y, Dale W, Fisher SG, Rodin M, Morrow GR, et al. Association of a cancer diagnosis with vulnerability and frailty in older Medicare beneficiaries. J Natl Cancer Inst. 2009;101:1206–15.PubMedCrossRef Mohile SG, Xian Y, Dale W, Fisher SG, Rodin M, Morrow GR, et al. Association of a cancer diagnosis with vulnerability and frailty in older Medicare beneficiaries. J Natl Cancer Inst. 2009;101:1206–15.PubMedCrossRef
19.
go back to reference Lash TL, Fox MP, Westrup JL, Fink AK, Silliman RA. Adherence to tamoxifen over the five-year course. Breast Cancer Res Treat. 2006;99:215–20.PubMedCrossRef Lash TL, Fox MP, Westrup JL, Fink AK, Silliman RA. Adherence to tamoxifen over the five-year course. Breast Cancer Res Treat. 2006;99:215–20.PubMedCrossRef
20.
go back to reference Owusu C, Buist DSM, Field TS, Lash TL, Thwin SS, Geiger AM, et al. Predictors of tamoxifen discontinuation among older women with estrogen receptor-breast cancer. J Clin Oncol. 2008;26:549–55.PubMedCrossRef Owusu C, Buist DSM, Field TS, Lash TL, Thwin SS, Geiger AM, et al. Predictors of tamoxifen discontinuation among older women with estrogen receptor-breast cancer. J Clin Oncol. 2008;26:549–55.PubMedCrossRef
21.
go back to reference Partridge AH, Wang PS, Winer EP, Avorn J. Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer. J Clin Oncol. 2003;21:602–6.PubMedCrossRef Partridge AH, Wang PS, Winer EP, Avorn J. Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer. J Clin Oncol. 2003;21:602–6.PubMedCrossRef
22.
go back to reference Ruddy K, Mayer E, Partridge A. Patient adherence and persistence with oral anticancer treatment. CA Cancer J Clin. 2009;59:56–66.PubMedCrossRef Ruddy K, Mayer E, Partridge A. Patient adherence and persistence with oral anticancer treatment. CA Cancer J Clin. 2009;59:56–66.PubMedCrossRef
23.
go back to reference Chlebowski RT, Geller ML. Adherence to endocrine therapy for breast cancer. Oncology. 2006;71:1–9.PubMed Chlebowski RT, Geller ML. Adherence to endocrine therapy for breast cancer. Oncology. 2006;71:1–9.PubMed
24.
go back to reference Pezzin LE, O’Niel MB, Nattinger AB. The economic consequences of breast cancer adjuvant hormonal treatments. J Gen Intern Med. 2009;24 Suppl 2:S446–50.PubMedCrossRef Pezzin LE, O’Niel MB, Nattinger AB. The economic consequences of breast cancer adjuvant hormonal treatments. J Gen Intern Med. 2009;24 Suppl 2:S446–50.PubMedCrossRef
26.
go back to reference Krouse RS, Herrinton LJ, Grant M, Wendel CS, Green SB, Mohler MJ, et al. Health-related quality of life among long-term rectal cancer survivors with an ostomy: manifestations by sex. J Clin Oncol. 2009;27:4664–70.PubMedCrossRef Krouse RS, Herrinton LJ, Grant M, Wendel CS, Green SB, Mohler MJ, et al. Health-related quality of life among long-term rectal cancer survivors with an ostomy: manifestations by sex. J Clin Oncol. 2009;27:4664–70.PubMedCrossRef
Metadata
Title
Cost-related medication nonadherence and cost-saving strategies used by elderly Medicare cancer survivors
Authors
Larissa Nekhlyudov
Jeanne Madden
Amy Johnson Graves
Fang Zhang
Stephen B. Soumerai
Dennis Ross-Degnan
Publication date
01-12-2011
Publisher
Springer US
Published in
Journal of Cancer Survivorship / Issue 4/2011
Print ISSN: 1932-2259
Electronic ISSN: 1932-2267
DOI
https://doi.org/10.1007/s11764-011-0188-4

Other articles of this Issue 4/2011

Journal of Cancer Survivorship 4/2011 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine