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Published in: Internal and Emergency Medicine 2/2019

01-03-2019 | IM - CASE RECORD

Syncope and autonomic failure in a middle-aged man

Authors: Giorgio Colombo, Emanuele Frattini, Elisa Ceriani, Massimo Zilocchi, Roberto Del Bo, Alessio DI Fonzo, Monica Solbiati

Published in: Internal and Emergency Medicine | Issue 2/2019

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Excerpt

An Albanian 54-year-old man presented to the Emergency Department (ED) after a transient loss of consciousness that occurred while walking in the street. The episode was preceded by dizziness, vertigo and palpitations, and was followed by fatigue and paraesthesia in the right arm and leg. A long-standing history (1–2 years) of lower limb fatigue with progressive walking problems, slow speech rate, confusion and severe weight loss (about 70 kg) was reported. The patient also described previous syncopal episodes similar to the present one. A patient’s friend, who had not seen him in years, noticed that the patient was more confused and slow in moving and speaking than what he recalled. …
Literature
1.
go back to reference Levy J, Hawkins PN, Rowczenio D, Godfrey T, Stawell R, Zamir E (2012) Familial amyloid polyneuropathy associated with the novel transthyretin variant Arg34Gly. Amyloid 19:201–203CrossRefPubMed Levy J, Hawkins PN, Rowczenio D, Godfrey T, Stawell R, Zamir E (2012) Familial amyloid polyneuropathy associated with the novel transthyretin variant Arg34Gly. Amyloid 19:201–203CrossRefPubMed
2.
3.
go back to reference Adams D, Suhr OB, Hund E et al (2016) First European Consensus For Diagnosis, management and treatment of transthyretin familial amyloid polyneuropathy. Curr Opin Neurol 29:S14–S26CrossRefPubMedPubMedCentral Adams D, Suhr OB, Hund E et al (2016) First European Consensus For Diagnosis, management and treatment of transthyretin familial amyloid polyneuropathy. Curr Opin Neurol 29:S14–S26CrossRefPubMedPubMedCentral
4.
go back to reference Van Gamaren II, Hazenberg BP, Bijzet J, van Rijswijk MH (2006) Diagnostic accuracy of subcutaneous aspiration for detecting systemic amyloidosis and its utility in clinical practice. Arthritis Rheum 54:2015–2021CrossRef Van Gamaren II, Hazenberg BP, Bijzet J, van Rijswijk MH (2006) Diagnostic accuracy of subcutaneous aspiration for detecting systemic amyloidosis and its utility in clinical practice. Arthritis Rheum 54:2015–2021CrossRef
5.
go back to reference Perfetto F, Cappelli F, Bergesio F et al (2013) Cardiac amyloidosis: the heart of the matter. Intern Emerg Med 8:191–203CrossRefPubMed Perfetto F, Cappelli F, Bergesio F et al (2013) Cardiac amyloidosis: the heart of the matter. Intern Emerg Med 8:191–203CrossRefPubMed
6.
go back to reference Kyle RA, Greipp PR (1983) Amyloidosis (AL). Clinical and laboratory features in 229 cases. Mayo Clin Proc 58:665PubMed Kyle RA, Greipp PR (1983) Amyloidosis (AL). Clinical and laboratory features in 229 cases. Mayo Clin Proc 58:665PubMed
7.
go back to reference Zhao L, Tian Z, Fang Q (2016) Diagnostic accuracy of cardiovascular magnetic resonance for patient with suspected cardiac amyloidosis, a systematic review and meta-analysis. BMC cardiovasc Disord. 16:129CrossRefPubMedPubMedCentral Zhao L, Tian Z, Fang Q (2016) Diagnostic accuracy of cardiovascular magnetic resonance for patient with suspected cardiac amyloidosis, a systematic review and meta-analysis. BMC cardiovasc Disord. 16:129CrossRefPubMedPubMedCentral
8.
go back to reference Costantino G, Montano N, Casazza G (2016) When should we change our clinical practice based on the results of a clinical study? Diagnostic accuracy studies II: the diagnostic accuracy. Intern Emerg Med 11:755–757CrossRefPubMed Costantino G, Montano N, Casazza G (2016) When should we change our clinical practice based on the results of a clinical study? Diagnostic accuracy studies II: the diagnostic accuracy. Intern Emerg Med 11:755–757CrossRefPubMed
9.
go back to reference Rahman JE, Helou EF, Gelzer-Bell R et al (2004) Noninvasive diagnosis of biopsy-proven cardiac amyloidosis. J Am Coll Cardiol 43:410CrossRefPubMed Rahman JE, Helou EF, Gelzer-Bell R et al (2004) Noninvasive diagnosis of biopsy-proven cardiac amyloidosis. J Am Coll Cardiol 43:410CrossRefPubMed
10.
11.
go back to reference Waddington Cruz M, Amass L, Keohane D, Schwartz J, Li H, Gundapaneni B (2016) Early intervention with tafamidis provide long term delay of neurologic progression in transthyretin hereditary amyloid polyneuropathy. Amyloid 23:178–183CrossRefPubMedPubMedCentral Waddington Cruz M, Amass L, Keohane D, Schwartz J, Li H, Gundapaneni B (2016) Early intervention with tafamidis provide long term delay of neurologic progression in transthyretin hereditary amyloid polyneuropathy. Amyloid 23:178–183CrossRefPubMedPubMedCentral
Metadata
Title
Syncope and autonomic failure in a middle-aged man
Authors
Giorgio Colombo
Emanuele Frattini
Elisa Ceriani
Massimo Zilocchi
Roberto Del Bo
Alessio DI Fonzo
Monica Solbiati
Publication date
01-03-2019
Publisher
Springer International Publishing
Published in
Internal and Emergency Medicine / Issue 2/2019
Print ISSN: 1828-0447
Electronic ISSN: 1970-9366
DOI
https://doi.org/10.1007/s11739-018-1871-5

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