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Obesity Surgery
Published in: Obesity Surgery 8/2021

01-08-2021 | Sleeve Gastrectomy | Original Contributions

Adherence to Nutritional Supplementation Determines Postoperative Vitamin D Status, but Not Levels of Bone Resorption Marker, in Sleeve-Gastrectomy Patients

Authors: Wen-Ling Liao, Wan-Ching Yang, Huey-Mei Shaw, Chi-Hsuan Lin, Chin-Ching Wu, Wan-Lin Hsu, Yao-Cheng Lu, Pei-Min Chao, Chih-Kun Huang

Published in: Obesity Surgery | Issue 8/2021

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Abstract

Background

Taking advantage of isomeric form of vitamin E in the supplement, adherence to supplement could be evaluated by changes in circulating α- and γ-tocopherol concentrations. Accordingly, effects of supplementation on postoperative nutrition and bone metabolism were studied in terms of adherence.

Methods

Thirty-eight SG patients were all prescribed a postoperative nutritional supplement containing a low dose of vitamin D (600 IU) and calcium (200 mg). Blood samples were collected prior to (M0) and 6 months after (M6) surgery and concentrations of nutrients and C-terminal telopeptide of type I collage (CTX), a marker of bone resorption, were measured. Adherence and non-adherence were stratified according to change (△, M6-M0) in serum α-tocopherol concentrations (> 0 vs. ≤ 0, respectively).

Results

When M0 and M6 were compared, there were significant increases in serum concentrations of 25(OH)D, α-tocopherol and selenium, whereas there were reductions in parathyroid hormone, ferritin, and γ-tocopherol. At M6, the prevalence of vitamin D insufficiency (25(OH)D < 30 ng/mL) and high CTX were 72 and 26%, respectively. When comparison was made between adherence and non-adherence, only △25(OH)D concentrations, but no other nutrients nor postoperative CTX differed. Multiple linear regression demonstrated that postoperative vitamin D status was independently associated with its preoperative concentrations (β = 0.85, p < 0.001) and adherence (β = 0.52, p < 0.05).

Conclusion

SG patients’ adherence to supplementation, even with a low dose of vitamin D and calcium, determined vitamin D status but not bone resorption marker concentrations, at least within 6 months after surgery.

Graphical abstract

Appendix
Available only for authorised users
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Metadata
Title
Adherence to Nutritional Supplementation Determines Postoperative Vitamin D Status, but Not Levels of Bone Resorption Marker, in Sleeve-Gastrectomy Patients
Authors
Wen-Ling Liao
Wan-Ching Yang
Huey-Mei Shaw
Chi-Hsuan Lin
Chin-Ching Wu
Wan-Lin Hsu
Yao-Cheng Lu
Pei-Min Chao
Chih-Kun Huang
Publication date
01-08-2021
Publisher
Springer US
Published in
Obesity Surgery / Issue 8/2021
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-021-05484-w

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