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Obesity Surgery
Published in: Obesity Surgery 7/2021

01-07-2021 | Obesity | Original Contributions

Analysis of the Functional Aspects of Sperm and Testicular Oxidative Stress in Individuals Undergoing Metabolic Surgery

Authors: Roberta Maria Fariello, Renata Cristina de Carvalho, Deborah M. Spaine, Rhayza R. Andretta, Elesiário M. Caetano Jr, Gustavo P. D. Sá, Agnaldo P. Cedenho, Renato Fraietta

Published in: Obesity Surgery | Issue 7/2021

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Abstract

Purpose

Metabolic surgery is a recommended treatment for obese patients that results in BMI reduction; however, the observed impact of this therapy on male fertility is inconsistent. This research aimed to study the effects of BMI changes after metabolic surgery on seminal analysis, sex hormonal profile, sperm functional integrity, and the seminal plasma lipid peroxidation levels.

Materials and Methods

A prospective study was performed in 15 patients for whom metabolic surgery was recommended. The patients were evaluated by the techniques proposed in this study before and after the surgical procedure for 12 months. In each analysis, the male sex hormonal profile, semen analysis, sperm functional integrity, and seminal lipid peroxidation levels were assessed.

Results

The surgery resulted in BMI reduction and improvement in seminal characteristics and male sex hormone profile. The semen analysis showed increases in volume, sperm progressive motility, and in sperm morphology and a decrease in immotile sperms. Sperm mitochondrial activity and sperm DNA integrity were improved, and the levels of seminal lipid peroxidation were decreased. The hormonal profile showed lower levels of estradiol and highest levels of luteinizing hormone (LH), sex hormone-binding globulin (SHBG), and testosterone.

Conclusion

BMI changes resulting from this treatment and its metabolic consequences can be associated with changes in the male fertile potential, leading to an improvement in the seminal quality, male sex hormone profile, sperm functional aspects, and levels of seminal lipid peroxidation, thus decreasing the testicular oxidative stress.

Graphical Abstract

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Metadata
Title
Analysis of the Functional Aspects of Sperm and Testicular Oxidative Stress in Individuals Undergoing Metabolic Surgery
Authors
Roberta Maria Fariello
Renata Cristina de Carvalho
Deborah M. Spaine
Rhayza R. Andretta
Elesiário M. Caetano Jr
Gustavo P. D. Sá
Agnaldo P. Cedenho
Renato Fraietta
Publication date
01-07-2021
Publisher
Springer US
Published in
Obesity Surgery / Issue 7/2021
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-021-05350-9

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