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01-04-2021 | Obesity | Original Contributions

Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Differently Affect Oxidative Damage Markers and their Correlations with Body Parameters

Authors: Fernanda A. Venâncio, Leandra A. Almeida, Paulo V. Zovico, Valério G. Barauna, Gustavo P. S. Miguel, Rogerio G. Pedrosa, Fabiano K. Haraguchi

Published in: Obesity Surgery | Issue 4/2021

Abstract

Background

Bariatric surgery improves oxidative damage, but little is known about the differences between Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). This study compared changes in lipid and protein oxidative damage markers and their correlations with body parameters of patients before and after RYGB or SG.

Methods

Body mass index (BMI), bioimpedance parameters, and biochemical parameters including lipid and protein oxidative damage markers were evaluated before and 6 months after surgery. Data were analyzed by t test or Mann-Whitney rank sum test and Spearman’s correlation coefficient between oxidative damage and other parameters.

Results

Twenty-five patients were submitted to RYGB and 14 to SG. There was a significant decrease of BMI, fat mass, fat-free mass, phase angle, serum total protein, transthyretin, and C-reactive protein in both groups (p < 0.05). Serum thiobarbituric acid reactive substances (TBARS), advanced oxidation protein products (AOPP), and serum lipids (p < 0.05) were significantly decreased in the RYGB group. TBARS levels were significantly correlated with serum total cholesterol (r = 0.468), LDL (r = 0.439), BMI (r = 0.424), and fat mass (r = 0.40) (p < 0.05). In the SG group, AOPP levels were significantly correlated with serum C-reactive protein (baseline: r = 0.53, 6 months: r = 0.64) (p < 0.05). Alterations in these levels were negatively correlated with changes in BIA parameters [resistance (r = −0.574), reactance (r = −0.736), and phase angle (r = 0.549)] (p < 0.05).

Conclusions

RYGB seems to be better in attenuating oxidative damage after 6 months. The BMI reduction in the RYGB group suggests a concomitant decrease of lipid oxidative damage. In the SG group, changes in BIA parameters were inversely correlated with protein oxidative damage.

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Title: Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Differently Affect Oxidative Damage Markers and their Correlations with Body Parameters
Authors: Fernanda A. Venâncio
Leandra A. Almeida
Paulo V. Zovico
Valério G. Barauna
Gustavo P. S. Miguel
Rogerio G. Pedrosa
Fabiano K. Haraguchi
Publication date: 01-04-2021
Publisher: Springer US
Keywords: Obesity
Obesity
Sleeve Gastrectomy
Bariatric Surgery
Bariatric Surgery
Published in: Obesity Surgery / Issue 4/2021
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-020-05179-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Differently Affect Oxidative Damage Markers and their Correlations with Body Parameters

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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