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Obesity Surgery
Published in: Obesity Surgery 9/2010

01-09-2010 | Clinical Research

Roux-en-Y Bypass Gastroplasty: Markers of Oxidative Stress 6 Months After Surgery

Authors: Fernanda Boesing, Emilia Addison Machado Moreira, Danilo Wilhelm-Filho, Silvana Virgínia Gagliotti Vigil, Eduardo Bennedetti Parizottto, Déborah Bunn Inácio, Guilherme Vannucchi Portari, Erasmo Benício Santos Moraes Trindade, Alceu Afonso Jordão-Júnior, Tânia Silvia Fröde

Published in: Obesity Surgery | Issue 9/2010

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Abstract

Background

This study examined the effect of weight loss on energy intake, vitamin C, E, β-carotene (diet/blood), reduced glutathione (GSH), C-reactive protein (CRP), thiobarbituric acid reactive substances (TBARS), catalase, and myeloperoxidase, in patients with Roux-en-Y bypass gastroplasty.

Methods

Prospective clinical study with control (C) and bariatric (B) groups (n = 20 each). Age was 38.8 ± 11.1 (C) and 37.8 ± 11.2 years (B), and body mass indices (BMI) were 22.4 ± 2.4 and 48.1 ± 8.7 kg/m2, respectively. Group C was assessed on a single occasion and B at three time points (basal period and 3 and 6 months after gastroplasty).

Results

BMI was decreased at three (38.3 ± 1.7, P = 0.018) and 6 months after surgery (34.9 ± 1.7, P < 0.001). Mean weight loss was 20.53 ± 1.1 after three and 27.96 ± 1.3 kg after 6 months. Serum vitamin C and β-carotene (P < 0.01 and P < 0.001, respectively) were increased at 6 months compared to basal. Basal serum vitamin C (P = 0.001) and β-carotene (P < 0.001) were lower compared to controls. Serum vitamin E corrected for cholesterol and triglycerides was higher in group B at three (P = 0.01) and 6 months (P = 0.001) and lower at basal (P < 0.001) compared to controls. GSH was higher in controls (P < 0.001) compared to basal. Catalase (P = 0.01) and TBARS (P < 0.001) were higher in group B at 6 months. TBARS were higher (P < 0.001) at basal compared to controls. Myeloperoxidase and CRP decreased in group B after three (P = 0.028, P = 0.010) and 6 months (P < 0.001, P = 0.001), respectively.

Conclusions

Roux-en-Y bypass gastroplasty led to decreased proinflammatory parameters together with increased nutritional antioxidants, catalase, and TBARS, and decreased GSH 6 months after surgery.
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Metadata
Title
Roux-en-Y Bypass Gastroplasty: Markers of Oxidative Stress 6 Months After Surgery
Authors
Fernanda Boesing
Emilia Addison Machado Moreira
Danilo Wilhelm-Filho
Silvana Virgínia Gagliotti Vigil
Eduardo Bennedetti Parizottto
Déborah Bunn Inácio
Guilherme Vannucchi Portari
Erasmo Benício Santos Moraes Trindade
Alceu Afonso Jordão-Júnior
Tânia Silvia Fröde
Publication date
01-09-2010
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 9/2010
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-010-0196-x

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