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01-01-2021 | Bariatric Surgery | Original Contributions

Circadian Misalignment Is Negatively Associated with the Anthropometric, Metabolic and Food Intake Outcomes of Bariatric Patients 6 Months After Surgery

Authors: Aline Cunha Carvalho, Maria Carliana Mota, Luisa Pereira Marot, Luís Augusto Mattar, José Américo Gomides de Sousa, Ana Cristina Tomaz Araújo, Camila Thaís da Costa Assis, Cibele Aparecida Crispim

Published in: Obesity Surgery | Issue 1/2021

Abstract

Purpose

Circadian misalignment has been associated with an increased risk of overweight and obesity, as well as changes in metabolic parameters. This study evaluated the association between social jet lag (SJL), a measure of circadian misalignment, and anthropometric, metabolic and food intake outcomes 6 months after bariatric surgery.

Materials and Methods

A total of 122 bariatric patients were included (77% female, aged 33 years (range 28–41); 79.5% underwent Roux-en-Y gastric bypass). Anthropometric, food consumption and SJL were evaluated in the preoperative evaluation and in the third and sixth months after surgery. SJL was calculated based on the absolute difference between the mid-sleep time on weekends and weekdays. Generalised estimating equations and linear regression were performed to evaluate the associations between mean SJL exposure and the outcomes.

Results

The interaction between SJL and follow-up time negatively influenced the evolution of weight (p = 0.01), BMI (p = 0.04) and insulin levels (p = 0.01). SJL had an effect on intake of calories (p = 0.001), carbohydrate (p = 0.005) and total (p = 0.007), monounsaturated (p = 0.03) and polyunsaturated fat (p < 0.001). Linear regression showed a negative association between mean SJL exposure over the 6 months and the percentage of weight loss (coefficient = − 0.30, p = 0.006), body weight loss (kg) (coefficient = − 0.17, p = 0.03) and the reduction of BMI (coefficient = − 0.24, p = 0.007).

Conclusions

SJL was negatively associated with anthropometric, metabolic and food consumption outcomes 6 months after bariatric surgery. Future studies with longer follow-up are needed to confirm these findings.

Trial Registration

Clinical Trials.gov: NCT03485352

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Title: Circadian Misalignment Is Negatively Associated with the Anthropometric, Metabolic and Food Intake Outcomes of Bariatric Patients 6 Months After Surgery
Authors: Aline Cunha Carvalho
Maria Carliana Mota
Luisa Pereira Marot
Luís Augusto Mattar
José Américo Gomides de Sousa
Ana Cristina Tomaz Araújo
Camila Thaís da Costa Assis
Cibele Aparecida Crispim
Publication date: 01-01-2021
Publisher: Springer US
Keywords: Bariatric Surgery
Bariatric Surgery
Published in: Obesity Surgery / Issue 1/2021
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-020-04873-x

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Circadian Misalignment Is Negatively Associated with the Anthropometric, Metabolic and Food Intake Outcomes of Bariatric Patients 6 Months After Surgery

Abstract

Purpose

Materials and Methods

Results

Conclusions

Trial Registration

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Materials and Methods

Results

Conclusions

Trial Registration

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