Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Obesity Surgery
Published in: Obesity Surgery 8/2020

01-08-2020 | Sleeve Gastrectomy | Original Contributions

Impact of a 12-Week Randomized Exercise Training Program on Lipid Profile in Severely Obese Patients Following Bariatric Surgery

Authors: Isabelle Tardif, Audrey Auclair, Marie-Eve Piché, Laurent Biertho, Simon Marceau, Frédéric-Simon Hould, Simon Biron, Stéfane Lebel, Odette Lescelleur, Paul Poirier

Published in: Obesity Surgery | Issue 8/2020

Login to get access

Abstract

Purpose

The benefit of exercise training on lipid profile in bariatric surgery patients is scarce. We assess the effect of a supervised exercise-training program on lipid profile following bariatric surgery.

Materials and Methods

A total of 60 patients were prospectively recruited, of those 49 completed the study (age 41 ± 11 years; body mass index 45.9 ± 6.1 kg/m2, 75% women). The bariatric surgery procedures performed were sleeve gastrectomy (SG) (n = 24) and biliopancreatic diversion with duodenal switch (BPD-DS) (n = 25). Of the 49 patients who completed the study, 34 had been randomized to a 12-week supervised exercise training program (exercise group) between the 3rd and the 6th month following bariatric surgery (SG = 17 and BPD-DS = 17). Fasting blood samples and anthropometric measurements were performed preoperatively and at 3, 6, and 12 months after bariatric surgery.

Results

At 6 months and 12 months, percentage of weight loss was similar between groups (6 months: − 29.6 ± 5.5 vs. − 27.8 ± 7.7%; P = 0.371; 12 months: − 38.4 ± 10.4 vs. − 37.9 ± 9.5%; P = 0.876 exercise vs. control). Both groups had an increase in HDL values between the 3nd and the 6th month following bariatric surgery. There was a significantly greater increment in HDL values in the exercise group (0.18 ± 0.14 vs. 0.07 ± 0.12 mmol/L, P = 0.014; exercise vs. control).

Conclusion

Our results showed a beneficial effect of a 12-week supervised exercise-training program in bariatric surgery patients showing similar weight loss on HDL-cholesterol levels without additional effect on LDL-cholesterol levels.
Appendix
Available only for authorised users
Literature
1.
Repas T. Obesity and dyslipidemia. S D Med. 2011;64(7):241–3. 5, 7 passimPubMed
2.
Zlabek JA, Grimm MS, Larson CJ, et al. The effect of laparoscopic gastric bypass surgery on dyslipidemia in severely obese patients. Surg Obes Relat Dis. 2005;1(6):537–42.PubMedCrossRef
3.
4.
Cunha FM, Oliveira J, Preto J, et al. The effect of bariatric surgery type on lipid profile: an age, sex, body mass index and excess weight loss matched study. Obes Surg. 2016;26(5):1041–7.PubMedCrossRef
5.
Kraus WE, Houmard JA, Duscha BD, et al. Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med. 2002;347(19):1483–92.PubMedCrossRef
6.
Kodama S, Tanaka S, Saito K, et al. Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: a meta-analysis. Arch Intern Med. 2007;167(10):999–1008.PubMedCrossRef
7.
Pattyn N, Cornelissen VA, Eshghi SR, et al. The effect of exercise on the cardiovascular risk factors constituting the metabolic syndrome: a meta-analysis of controlled trials. Sports Med. 2013;43(2):121–33. Pubmed Central PMCID: PMC3693431PubMedCrossRef
8.
Anderssen SA, Carroll S, Urdal P, et al. Combined diet and exercise intervention reverses the metabolic syndrome in middle-aged males: results from the Oslo diet and exercise study. Scand J Med Sci Sports. 2007;17(6):687–95.PubMedCrossRef
9.
Kelley GA, Kelley KS, Tran ZV. Exercise, lipids, and lipoproteins in older adults: a meta-analysis. Prev Cardiol. 2005 Fall;8(4):206–14. Pubmed Central PMCID: PMC2447857.
10.
Ryan DH, Johnson WD, Myers VH, et al. Nonsurgical weight loss for extreme obesity in primary care settings: results of the Louisiana obese subjects study. Arch Intern Med. 2010;170(2):146–54.PubMedCrossRef
11.
Snowling NJ, Hopkins WG. Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients: a meta-analysis. Diabetes Care. 2006;29(11):2518–27.PubMedCrossRef
12.
13.
Marcon ER, Baglioni S, Bittencourt L, et al. What is the best treatment before bariatric surgery? Exercise, exercise and group therapy, or conventional waiting: a randomized controlled trial. Obes Surg. 2017;27(3):763–773.
14.
Marcon ER, Gus I, Neumann CR. Impact of a minimum program of supervised exercises in the cardiometabolic risk in patients with morbid obesity. Arq Bras Endocrinol Metabol. 2011;55(5):331–8. Impacto de um programa minimo de exercicios fisicos supervisionados no risco cardiometabolico de pacientes com obesidade morbidaPubMedCrossRef
15.
Alam S, Stolinski M, Pentecost C, et al. The effect of a six-month exercise program on very low-density lipoprotein apolipoprotein B secretion in type 2 diabetes. J Clin Endocrinol Metab. 2004 Feb;89(2):688–94.PubMedCrossRef
16.
Leon AS, Sanchez OA. Response of blood lipids to exercise training alone or combined with dietary intervention. Med Sci Sports Exerc. 2001;33(6 Suppl):S502–15. discussion S28–9PubMedCrossRef
17.
Janssen I, Fortier A, Hudson R, et al. Effects of an energy-restrictive diet with or without exercise on abdominal fat, intermuscular fat, and metabolic risk factors in obese women. Diabetes Care. 2002;25(3):431–8.PubMedCrossRef
18.
Banz WJ, Maher MA, Thompson WG, et al. Effects of resistance versus aerobic training on coronary artery disease risk factors. Exp Biol Med (Maywood). 2003;228(4):434–40.CrossRef
19.
Heffron SP, Parikh A, Volodarskiy A, et al. Changes in lipid profile of obese patients following contemporary bariatric surgery: a meta-analysis. Am J Med. 2016;129(9):952–9.
20.
Piche ME, Auclair A, Harvey J, et al. How to choose and use bariatric surgery in 2015. Can J Cardiol. 2015;31(2):153–66.PubMedCrossRef
21.
Ruiz-Tovar J, Zubiaga L, Llavero C, et al. Serum cholesterol by morbidly obese patients after laparoscopic sleeve gastrectomy and additional physical activity. Obes Surg. 2014;24(3):385–9.PubMedCrossRef
22.
Wefers JF, Woodlief TL, Carnero EA, et al. Relationship among physical activity, sedentary behaviors, and cardiometabolic risk factors during gastric bypass surgery-induced weight loss. Surg Obes Relat Dis. 2017;13(2):210–9.PubMedCrossRef
23.
Auclair A, Martin J, Bastien M, et al. Is there a role for visceral adiposity in inducing type 2 diabetes remission in severely obese patients following biliopancreatic diversion with duodenal switch surgery? Obes Surg. 2016;26(8):1717–27.PubMedCrossRef
24.
Auclair A, Piché ME, Biertho L, et al. Changes in fat-free mass and muscle mass at 6 and 12 months after biliopancreatic diversion with duodenal switch surgery. Surg Obes Relat Dis. 2020; [Epub ahead of print].
25.
Marceau P, Hould FS, Simard S, et al. Biliopancreatic diversion with duodenal switch. World J Surg. 1998;22(9):947–54.PubMedCrossRef
26.
Marceau P, Biron S, Hould FS, et al. Duodenal switch: long-term results. Obes Surg. 2007;17(11):1421–30.PubMedCrossRef
27.
Piche ME, Martin J, Cianflone K, et al. Changes in predicted cardiovascular disease risk after biliopancreatic diversion surgery in severely obese patients. Metabolism. 2014;63(1):79–86.PubMedCrossRef
28.
Martin J, Bergeron S, Pibarot P, et al. Impact of bariatric surgery on N-terminal fragment of the prohormone brain natriuretic peptide and left ventricular diastolic function. Can J Cardiol. 2013;29(8):969–75.PubMedCrossRef
29.
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499–502.PubMedCrossRef
30.
31.
Ren ZQ, Lu GD, Zhang TZ, et al. Effect of physical exercise on weight loss and physical function following bariatric surgery: a meta-analysis of randomised controlled trials. BMJ Open. 2018;8(10):e023208. Pubmed Central PMCID: PMC6252776PubMedPubMedCentralCrossRef
32.
Aminian A, Zelisko A, Kirwan JP, et al. Exploring the impact of bariatric surgery on high density lipoprotein. Surg Obes Relat Dis. 2015;11(1):238–47.PubMedCrossRef
33.
Nguyen NT, Varela E, Sabio A, et al. Resolution of hyperlipidemia after laparoscopic Roux-en-Y gastric bypass. J Am Coll Surg. 2006;203(1):24–9.PubMedCrossRef
34.
35.
Genest J, McPherson R, Frohlich J, et al. 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations. Can J Cardiol. 2009;25(10):567–79. Pubmed Central PMCID: PMC2782500PubMedPubMedCentralCrossRef
36.
Hegele RA, Gidding SS, Ginsberg HN, et al. Nonstatin low-density lipoprotein-lowering therapy and cardiovascular risk reduction-statement from ATVB council. Arterioscler Thromb Vasc Biol. 2015;35(11):2269–80. Pubmed Central PMCID: PMC4758700PubMedPubMedCentralCrossRef
37.
Turk Y, Theel W, Kasteleyn MJ, et al. High intensity training in obesity: a meta-analysis. Obes Sci Pract. 2017;3(3):258–71. Pubmed Central PMCID: PMC5598019PubMedPubMedCentralCrossRef
38.
Miller M, Stone NJ, Ballantyne C, et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2011;123(20):2292–333.PubMedCrossRef
39.
Shah M, Snell PG, Rao S, et al. High-volume exercise program in obese bariatric surgery patients: a randomized, controlled trial. Obesity (Silver Spring). 2011;19(9):1826–34.CrossRef
Metadata
Title
Impact of a 12-Week Randomized Exercise Training Program on Lipid Profile in Severely Obese Patients Following Bariatric Surgery
Authors
Isabelle Tardif
Audrey Auclair
Marie-Eve Piché
Laurent Biertho
Simon Marceau
Frédéric-Simon Hould
Simon Biron
Stéfane Lebel
Odette Lescelleur
Paul Poirier
Publication date
01-08-2020
Publisher
Springer US
Published in
Obesity Surgery / Issue 8/2020
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-020-04647-5

Other articles of this Issue 8/2020

Obesity Surgery 8/2020 Go to the issue

Review

Missing Something? Comparisons of Effectiveness and Outcomes of Bariatric Surgery Procedures and Their Preferred Reporting: Refining the Evidence Base

Review

Antiemetic Prophylaxis and Anesthetic Approaches to Reduce Postoperative Nausea and Vomiting in Bariatric Surgery Patients: a Systematic Review

Review

Contributing of Cognitive-Behavioral Therapy in the Context of Bariatric Surgery: a Review of the Literature

Original Contributions

An Evaluation of the Modern North American Bariatric Surgery Landscape: Current Trends and Predictors of Procedure Selection

Original Contributions

Racial Disparities in Bariatric Surgery Complications and Mortality Using the MBSAQIP Data Registry

Original Contributions

Utility of Inflammatory Markers in Detection of Perioperative Morbidity After Laparoscopic Sleeve Gastrectomy, Laparoscopic Roux-en-Y Gastric Bypass, and One-Anastomosis Gastric Bypass—Multicenter Study