Skip to main content
Top
Published in: Obesity Surgery 2/2019

01-02-2019 | Original Contributions

Multimodal Postoperative Pain Control Is Effective and Reduces Opioid Use After Laparoscopic Roux-en-Y Gastric Bypass

Authors: Ryan D. Horsley, Ellen D. Vogels, Daaron A. P. McField, David M. Parker, Charles Medico, James Dove, Marcus Fluck, Jon D. Gabrielsen, Michael R. Gionfriddo, Anthony T. Petrick

Published in: Obesity Surgery | Issue 2/2019

Login to get access

Abstract

Background

Opioids have been the mainstay for postoperative pain relief for many decades. Recently, opioid-related adverse events and death have been linked to postoperative dependency. Multimodal approaches to postoperative pain control may be part of the solution to this health care crisis. The safety and effectiveness of multimodal pain control regimens after laparoscopic Roux-en-Y gastric bypass (LRYGB) has not been well studied. The primary aim of our study was to determine if an evidence-based, multimodal pain regimen during hospitalization could decrease the total oral morphine equivalent (TME) use after LRYGB.

Study Design

We conducted a retrospective cohort study comparing outcomes prior to the implementation of a multimodal pain protocol (December 2010–December 2012) to those after implementation (April 2013–July 2015). The protocol utilized oral celecoxib and scheduled oral acetaminophen for pain control, with opioids used only as needed for breakthrough pain. Data was extracted from an electronic medical record and an institutionally maintained database of all patients undergoing bariatric surgery at a single center.

Results

Compared to controls, the multimodal pain regimen significantly reduced TME used and maximum pain scores with no change in mean pain scores. Multimodal pain protocol patients had a shorter length of stay with no increase in bleeding complications or marginal ulcer rates.

Conclusions

An opioid-sparing multimodal pain regimen adequately controls pain while reducing TME use. The regimen appears to be safe and was associated with a reduced length of stay in patients undergoing LRYGB.
Literature
1.
go back to reference Minkowitz HS, Gruschkus SK, Shah M, et al. Adverse drug events among patients receiving postsurgical opioids in a large health system: risk factors and outcomes. Am J Health-Syst Ph. 2014;71(18):1556–65.CrossRef Minkowitz HS, Gruschkus SK, Shah M, et al. Adverse drug events among patients receiving postsurgical opioids in a large health system: risk factors and outcomes. Am J Health-Syst Ph. 2014;71(18):1556–65.CrossRef
2.
go back to reference Alam A, Gomes T, Zheng H, et al. Long-term analgesic use after low-risk surgery: a retrospective cohort study. Arch Intern Med. 2012;172(5):425–30.CrossRefPubMed Alam A, Gomes T, Zheng H, et al. Long-term analgesic use after low-risk surgery: a retrospective cohort study. Arch Intern Med. 2012;172(5):425–30.CrossRefPubMed
3.
go back to reference Wendling A, Wudyka A. Narcotic addiction following gastric bypass surgery--a case study. Obes Surg. 2011;21(5):680–3.CrossRefPubMed Wendling A, Wudyka A. Narcotic addiction following gastric bypass surgery--a case study. Obes Surg. 2011;21(5):680–3.CrossRefPubMed
4.
go back to reference Raebel MA, Newcomer SR, Bayliss EA, et al. Chronic opioid use emerging after bariatric surgery. Pharmacoepidemiol Drug Saf. 2014;23(12):1247–57.CrossRefPubMed Raebel MA, Newcomer SR, Bayliss EA, et al. Chronic opioid use emerging after bariatric surgery. Pharmacoepidemiol Drug Saf. 2014;23(12):1247–57.CrossRefPubMed
5.
go back to reference King WC, Chen J-Y, Belle SH, et al. Use of prescribed opioids before and after bariatric surgery: prospective evidence from a U.S. multicenter cohort study. Surg Obes Relat Dis. 2017;13(8):1337–46.CrossRefPubMedPubMedCentral King WC, Chen J-Y, Belle SH, et al. Use of prescribed opioids before and after bariatric surgery: prospective evidence from a U.S. multicenter cohort study. Surg Obes Relat Dis. 2017;13(8):1337–46.CrossRefPubMedPubMedCentral
6.
go back to reference Ghaferi AA, Mohanty S, Lee JS, Stricklen A, Ross R, Carlin AM. Bariatric Surgical Patients at Risk for Newly Persistent Opioid Use. Am Coll Surg; 2017. Ghaferi AA, Mohanty S, Lee JS, Stricklen A, Ross R, Carlin AM. Bariatric Surgical Patients at Risk for Newly Persistent Opioid Use. Am Coll Surg; 2017.
7.
8.
go back to reference Apfel C, Philip B, Cakmakkaya O, et al. Who is at risk for postdischarge nausea and vomiting after ambulatory surgery? Anesthesiology. 2012;117(3):475–86.CrossRefPubMed Apfel C, Philip B, Cakmakkaya O, et al. Who is at risk for postdischarge nausea and vomiting after ambulatory surgery? Anesthesiology. 2012;117(3):475–86.CrossRefPubMed
9.
go back to reference Macht R, George J, Ameli O, et al. Factors associated with bariatric postoperative emergency department visits. Surg Obes Relat Dis. 2016;12(10):1826–31.CrossRefPubMed Macht R, George J, Ameli O, et al. Factors associated with bariatric postoperative emergency department visits. Surg Obes Relat Dis. 2016;12(10):1826–31.CrossRefPubMed
10.
go back to reference Berger ER, Huffman KM, Fraker T, et al. Prevalence and risk factors for bariatric surgery readmissions: findings from 130,007 Admissions in the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program. Ann Surg. 2016;15. Berger ER, Huffman KM, Fraker T, et al. Prevalence and risk factors for bariatric surgery readmissions: findings from 130,007 Admissions in the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program. Ann Surg. 2016;15.
11.
go back to reference Aman MW, Stem M, Schweitzer MA, et al. Early hospital readmission after bariatric surgery. Surg Endosc. 2016;30(6):2231–8.CrossRefPubMed Aman MW, Stem M, Schweitzer MA, et al. Early hospital readmission after bariatric surgery. Surg Endosc. 2016;30(6):2231–8.CrossRefPubMed
12.
go back to reference Khorgami Z, Andalib A, Aminian A, et al. Predictors of readmission after laparoscopic gastric bypass and sleeve gastrectomy: a comparative analysis of ACS-NSQIP database. Surg Endosc. 2016;30(6):2342–50.CrossRefPubMed Khorgami Z, Andalib A, Aminian A, et al. Predictors of readmission after laparoscopic gastric bypass and sleeve gastrectomy: a comparative analysis of ACS-NSQIP database. Surg Endosc. 2016;30(6):2342–50.CrossRefPubMed
13.
go back to reference Sippey M, Kasten KR, Chapman WH, et al. 30-day readmissions after sleeve gastrectomy versus Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2016;12(5):991–6.CrossRefPubMed Sippey M, Kasten KR, Chapman WH, et al. 30-day readmissions after sleeve gastrectomy versus Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2016;12(5):991–6.CrossRefPubMed
14.
go back to reference Abraham CR, Werter CR, Ata A, et al. Predictors of hospital readmission after bariatric surgery. J Am Coll Surg. 2015;221(1):220–7.CrossRefPubMed Abraham CR, Werter CR, Ata A, et al. Predictors of hospital readmission after bariatric surgery. J Am Coll Surg. 2015;221(1):220–7.CrossRefPubMed
16.
go back to reference Frey WC, Pilcher J. Obstructive sleep-related breathing disorders in patients evaluated for bariatric surgery. Obes Surg. 2003;13(5):676–83.CrossRefPubMed Frey WC, Pilcher J. Obstructive sleep-related breathing disorders in patients evaluated for bariatric surgery. Obes Surg. 2003;13(5):676–83.CrossRefPubMed
17.
go back to reference Peromaa-Haavisto P, Tuomilehto H, Kossi J, et al. Prevalence of obstructive sleep apnoea among patients admitted for bariatric surgery. A prospective multicentre trial. Obes Surg. 2016;26(7):1384–90.CrossRefPubMed Peromaa-Haavisto P, Tuomilehto H, Kossi J, et al. Prevalence of obstructive sleep apnoea among patients admitted for bariatric surgery. A prospective multicentre trial. Obes Surg. 2016;26(7):1384–90.CrossRefPubMed
19.
go back to reference Chou R, Gordon DB, de Leon-Casasola OA, et al. Management of postoperative pain: a clinical practice guideline from the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists’ Committee on Regional Anesthesia, executive committee, and administrative council. J Pain. 2016;17(2):131–57.CrossRefPubMed Chou R, Gordon DB, de Leon-Casasola OA, et al. Management of postoperative pain: a clinical practice guideline from the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists’ Committee on Regional Anesthesia, executive committee, and administrative council. J Pain. 2016;17(2):131–57.CrossRefPubMed
20.
go back to reference Thorell A, MacCormick AD, Awad S, et al. Guidelines for perioperative care in bariatric surgery: enhanced recovery after surgery (ERAS) society recommendations. World J Surg. 2016;40(9):2065–83.CrossRefPubMed Thorell A, MacCormick AD, Awad S, et al. Guidelines for perioperative care in bariatric surgery: enhanced recovery after surgery (ERAS) society recommendations. World J Surg. 2016;40(9):2065–83.CrossRefPubMed
22.
go back to reference Petrick AT, Still CD, Wood CG, et al. Feasibility and impact of an evidence-based program for gastric bypass surgery. J Am Coll Surg. 2015;220(5):855–62.CrossRefPubMed Petrick AT, Still CD, Wood CG, et al. Feasibility and impact of an evidence-based program for gastric bypass surgery. J Am Coll Surg. 2015;220(5):855–62.CrossRefPubMed
24.
go back to reference Paulozzi L, Baldwin G, Franklin G, et al. CDC grand rounds: prescription drug overdoses - a U.S. epidemic. MMWR Morb Mortal Wkly Rep. 2012;61(1):10–3. Paulozzi L, Baldwin G, Franklin G, et al. CDC grand rounds: prescription drug overdoses - a U.S. epidemic. MMWR Morb Mortal Wkly Rep. 2012;61(1):10–3.
25.
go back to reference Kharasch ED, Brunt LM. Perioperative opioids and public health. Anesthesiology. 2016;124(4):960–5.CrossRefPubMed Kharasch ED, Brunt LM. Perioperative opioids and public health. Anesthesiology. 2016;124(4):960–5.CrossRefPubMed
26.
go back to reference Waljee JF, Li L, Brummett CM, et al. Iatrogenic opioid dependence in the United States: are surgeons the gatekeepers? Ann Surg. 2017;265(4):728–30.CrossRefPubMed Waljee JF, Li L, Brummett CM, et al. Iatrogenic opioid dependence in the United States: are surgeons the gatekeepers? Ann Surg. 2017;265(4):728–30.CrossRefPubMed
28.
go back to reference Ziemann-Gimmel P, Hensel P, Koppman J, et al. Multimodal analgesia reduces narcotic requirements and antiemetic rescue medication in laparoscopic Roux-en-Y gastric bypass surgery. Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery. 2013;9(6):975–80.CrossRef Ziemann-Gimmel P, Hensel P, Koppman J, et al. Multimodal analgesia reduces narcotic requirements and antiemetic rescue medication in laparoscopic Roux-en-Y gastric bypass surgery. Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery. 2013;9(6):975–80.CrossRef
29.
go back to reference Song K, Melroy MJ, Whipple OC. Optimizing multimodal analgesia with intravenous acetaminophen and opioids in postoperative bariatric patients. Pharmacotherapy. 2014;34(Suppl 1):14s–21s.CrossRefPubMed Song K, Melroy MJ, Whipple OC. Optimizing multimodal analgesia with intravenous acetaminophen and opioids in postoperative bariatric patients. Pharmacotherapy. 2014;34(Suppl 1):14s–21s.CrossRefPubMed
30.
go back to reference Wang S, Saha R, Shah N, et al. Effect of intravenous acetaminophen on postoperative opioid use in bariatric surgery patients. Pharm Ther. 2015;40(12):847–50. Wang S, Saha R, Shah N, et al. Effect of intravenous acetaminophen on postoperative opioid use in bariatric surgery patients. Pharm Ther. 2015;40(12):847–50.
Metadata
Title
Multimodal Postoperative Pain Control Is Effective and Reduces Opioid Use After Laparoscopic Roux-en-Y Gastric Bypass
Authors
Ryan D. Horsley
Ellen D. Vogels
Daaron A. P. McField
David M. Parker
Charles Medico
James Dove
Marcus Fluck
Jon D. Gabrielsen
Michael R. Gionfriddo
Anthony T. Petrick
Publication date
01-02-2019
Publisher
Springer US
Published in
Obesity Surgery / Issue 2/2019
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-018-3526-z

Other articles of this Issue 2/2019

Obesity Surgery 2/2019 Go to the issue