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Obesity Surgery
Published in: Obesity Surgery 3/2017

01-03-2017 | Original Contributions

Influence of New Modified Biliopancreatic Diversion on Blood Glucose and Lipids in GK rats

Authors: Shangeng Weng, Bin Zhang, Changguo Xu, Su Feng, Hongxing He

Published in: Obesity Surgery | Issue 3/2017

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Abstract

Background

This study aimed to investigate the influence of new biliopancreatic diversion (NBPD) and duodenal-jejunal bypass (DJB) surgery on blood glucose, lipids, gastrointestinal hormones, and insulin in Goto-Kakizaki (GK) rats, an animal model for type 2 diabetes, in order to elucidate the mechanisms underlying the therapeutic effect of these types of surgery on this clinical condition.

Methods

Thirty 30 male GK rats (SPF) aged 12 weeks were randomly assigned into three groups (n = 10 per group): sham group, NBPD group, and DJB group. Body weight, random plasma glucose, fasting plasma glucose (FPG), oral glucose tolerance (OGT), blood lipids, plasma insulin, glucagon like peptide-1 (GLP-1), and gastric inhibitory polypeptide (GIP) were measured before and after surgery.

Results

NBPD surgery improved glucose tolerance, decreased fasting free fatty acids, triglycerides, and cholesterol. It also increased fasting and postprandial GIP, but caused no change in GLP-1. DJB surgery produced results similar to NBPD surgery except for causing a decrease in postprandial GLP-1 and insulin, and a larger increase in fasting GIP.

Conclusions

Moving the biliopancreatic duct outlet to the mid-jejunum (NBPD surgery) improves glucose tolerance and increases GIP, but does not change GLP-1. Adding duodenal bypass (DJB surgery) increases fasting GIP and decreases postprandial GLP-1.
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Metadata
Title
Influence of New Modified Biliopancreatic Diversion on Blood Glucose and Lipids in GK rats
Authors
Shangeng Weng
Bin Zhang
Changguo Xu
Su Feng
Hongxing He
Publication date
01-03-2017
Publisher
Springer US
Published in
Obesity Surgery / Issue 3/2017
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-016-2320-z

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