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Obesity Surgery
Published in: Obesity Surgery 1/2008

01-01-2008

Influence of Sleeve Gastrectomy on Several Experimental Models of Obesity: Metabolic and Hormonal Implications

Authors: Fàtima Sabench Pereferrer, Mercè Hernàndez Gonzàlez, Albert Feliu Rovira, Santiago Blanco Blasco, Antonio Morandeira Rivas, Daniel del Castillo Déjardin

Published in: Obesity Surgery | Issue 1/2008

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Abstract

Background

Ghrelin is an important factor in the regulation of intake. Most ghrelin is synthesized in the gastric fundus, but this is not the only location. The aim of this experimental study was to analyze the effect of sleeve gastrectomy (removing fundus) on the volume of intake in four experimental models and determine how this relates to changes in weight, plasmatic levels of glycemia, ghrelin, GLP-1, and insulin.

Methods

Sleeve gastrectomy was performed on four experimental models: (1) non-obesity; (2) exogenous obesity caused by excessive calorie intake; (3) genetically determined obesity (Zucker rats); and (4) genetically determined obesity and type 2 diabetes mellitus (Zucker diabetic fatty; ZDF rats). Model 2 had a control group on which sleeve gastrectomy was not performed.

Results

In the non-obese group, there were few changes after intervention, but in model 2, sleeve gastrectomy led to normalization of weight and endocrine–metabolic parameters that were the same as those for non-obese rats. The exception was for GLP-1, which has an anorexigenic effect: GLP-1 remained higher. In Zucker rats, sleeve gastrectomy had a slight effect on all parameters. In ZDF rats, sleeve gastrectomy led to a reduction in intake and a stabilization of weight.

Conclusions

Sleeve gastrectomy is a very good option for exogenous obesity. Normalization of hormonal levels led us to find an extragastric ghrelin production.
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Metadata
Title
Influence of Sleeve Gastrectomy on Several Experimental Models of Obesity: Metabolic and Hormonal Implications
Authors
Fàtima Sabench Pereferrer
Mercè Hernàndez Gonzàlez
Albert Feliu Rovira
Santiago Blanco Blasco
Antonio Morandeira Rivas
Daniel del Castillo Déjardin
Publication date
01-01-2008
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 1/2008
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-007-9351-4

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