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01-11-2015 | Brief Communication

rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery

Authors: Laura J. Rasmussen-Torvik, Abigail S. Baldridge, Jennifer A. Pacheco, Sharon A. Aufox, Kwang-Youn A. Kim, Jonathan C. Silverstein, Erwin W. Denham, Eric Hungness, Maureen E. Smith, Philip Greenland

Published in: Obesity Surgery | Issue 11/2015

Abstract

We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p = .004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p < .05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.

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Title: rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery
Authors: Laura J. Rasmussen-Torvik
Abigail S. Baldridge
Jennifer A. Pacheco
Sharon A. Aufox
Kwang-Youn A. Kim
Jonathan C. Silverstein
Erwin W. Denham
Eric Hungness
Maureen E. Smith
Philip Greenland
Publication date: 01-11-2015
Publisher: Springer US
Published in: Obesity Surgery / Issue 11/2015
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-015-1872-7

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rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery

Abstract

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Abstract

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