Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Obesity Surgery
Published in: Obesity Surgery 1/2015

Open Access 01-01-2015 | New Concept

Early Experience with Customized, Meal-Triggered Gastric Electrical Stimulation in Obese Patients

Authors: M. Miras, M. Serrano, C. Durán, C. Valiño, S. Canton

Published in: Obesity Surgery | Issue 1/2015

Login to get access

Abstract

Background

We report our initial gastric electrical stimulation experience using the abiliti® system for the treatment of obese patients followed for 1 year.

Method

Between March 2011 and June 2013, 27 obese patients (BMI 30 to 46 kg/m2) were enrolled in a prospective open label study and implanted with a gastric stimulator. The patients were provided with nutritional support, and sensor-based behavioral feedback.

Results

At 12 months, percent excess weight loss (%EWL) obtained was 49.3 ± 19.2 % with no significant differences between gender or age sub-groups. The %EWL data were segmented into two groups according to BMI 30–40 kg/m2 patients (obesity grade I and II) and BMI >40 kg/m2, with the results of weight loss being significantly higher for the lower BMI group (59.1 ± 19.5 vs. 46.7 ± 13.4, respectively, p < 0.01). One subject requested to have his device explanted, and the minor postoperative adverse events were resolved without hospital admission. All patients experienced early satiety and reduced their intake.

Conclusions

After 12 months of follow-up, gastric electrical stimulation treatment appears to be a safe and effective option for weight loss in obese subjects. Long-term follow-up and further studies are warranted.
Literature
1.
2.
Rodriguez-Artalejo F, Graciani A, Guallar-Castilló P, Leon-Munoz LM, Zuluaga C, Lopez-Garcia E, et al. Rationale and methods of the study on nutrition and cardiovascular risk in Spain (ENRICA). Rev Esp Cardiol. 2011;64(10):876–82.PubMedCrossRef
3.
WHO. Obesity: preventing and managing the global epidemic. Report of a WHO Consultation on Obesity, Geneva, June 1997. Switzerland: WHO; 1998.
4.
Stunkard AJ, Messick S. The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychosom Res. 1985;29(1):71–83.PubMedCrossRef
5.
Shikora SA, Bergenstal R, Bessler M, Brody F, Foster G, Frank A, et al. Implantable gastric stimulation for the treatment of clinical severe obese: result of SHAPE trial. Surg Obes Relat Dis. 2009;5:31–7.PubMedCrossRef
6.
Cigaina V. Gastric pacing as therapy for morbid obesity: preliminary results. Obes Surg. 2002;12(3):421.CrossRef
7.
De Luca M, Segato G, Busetto L, Favretti F, Aigner F, Weiss H, et al. Progress in implantable gastric stimulation: summary of results of the European multi-centre study. Obes Surg. 2004;14(Suppl1):S33–9.PubMedCrossRef
8.
Favretti F, De Luca M, Segato G, Busetto L, Ceoloni A, Magon A, et al. Treatment of morbid obesity with the Transcend Implantable Gastric Stimulator (IGS): a prospective survey. Obes Surg. 2004;14(5):666–70.PubMedCrossRef
9.
Shikora SA. Implantable gastric stimulation—the surgical procedure: combining safety with simplicity. Obes Surg. 2004;14(Suppl1):S9–S13.PubMedCrossRef
10.
Lebovitz HE, Ludvik B, Yaniv I, Haddad W, Schwartz T, Aviv R. Metacure Investigator Group. Fasting plasma triglycerides predict the glycaemic response to treatment of type 2 diabetes by gastric electrical stimulation. A novel lipotoxicity paradigm. Diabet Med. 2013;30(6):687–93.PubMedCentralPubMedCrossRef
11.
Shikora S, Toouli J, Herrera MF, Kulseng B, Zulewski H, Brancatisano R, et al. Vagal blocking improves glycemic control and elevated blood pressure in obese subjects with type 2 diabetes mellitus. Journal of Obesity. 2013;2013. doi:10.​1155/​2013/​245683.
12.
Tang M, Zhang J, Chen JD. Central mechanisms of gastric electrical stimulation involving neurons in the paraventricular nucleus of the hypothalamus in rats. Obes Surg. 2006;16(3):344–52.PubMedCrossRef
13.
Lei Y, Xing J, Chen J. The effect on gastric tone of gastric electrical stimulation with trains of short pulses varies with sites and stimulation conditions. Dig Dis Sci. 2008;53(8):2066–71.PubMedCrossRef
14.
Zhu H, Chen JD. Implantable gastric stimulation inhibits gastric motility via sympathetic pathway in dogs. Obes Surg. 2005;15(1):95–100.PubMedCrossRef
15.
Aelen P, Jurkov A, Aulanier A, Mintchev MP. Pilot acute study of feedback-controlled retrograde peristalsis invoked by neural gastric electrical stimulation. Physiol Meas. 2009;30(3):309–22.PubMedCrossRef
16.
17.
Oster G, Thompson D, Edelsberg J, Bird AP, Colditz GA. Lifetime health and economic benefits of weight loss among obese persons. Am J Public Health. 1999;89(10):1536–42.PubMedCentralPubMedCrossRef
18.
19.
Kuhlmann HW, Falcone RA, Wolf AM. Cost-effective bariatric surgery in Germany today. Obes Surg. 2000;10(6):549–52.PubMedCrossRef
Metadata
Title
Early Experience with Customized, Meal-Triggered Gastric Electrical Stimulation in Obese Patients
Authors
M. Miras
M. Serrano
C. Durán
C. Valiño
S. Canton
Publication date
01-01-2015
Publisher
Springer US
Published in
Obesity Surgery / Issue 1/2015
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-014-1498-1

Other articles of this Issue 1/2015

Obesity Surgery 1/2015 Go to the issue

Original Contributions

Predicting Remission of Diabetes After RYGB Surgery Following Intensive Management to Optimize Preoperative Glucose Control

Letter to the Editor

Standardizing or Tailoring Bariatric Surgery

Brief Communication

The Effect of Insurance Status on Pre- and Post-operative Bariatric Surgery Outcomes

Letter to the Editor

Laparoscopic Roux-en-Y Gastric Bypass: Creation of the Neogastric Pouch

Review Article

Bariatric Surgery and Liver Transplantation: a Systematic Review a New Frontier for Bariatric Surgery

Original Contributions

Cardiovascular Risk Profile in Mediterranean Patients Submitted to Bariatric Surgery and Intensive Lifestyle Intervention: Impact of Both Interventions After 1 Year of Follow-Up