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01-01-2012 | Basic Science Research

Only C-Reactive Protein, but not TNF-α or IL6, Reflects the Improvement in Inflammation after Bariatric Surgery

Authors: Eva Pardina, Roser Ferrer, Juan Antonio Baena-Fustegueras, Joaquín Rivero, Albert Lecube, Jose Manuel Fort, Víctor Vargas, Roberto Catalán, Julia Peinado-Onsurbe

Published in: Obesity Surgery | Issue 1/2012

Abstract

Background

Increased C-reactive protein (CRP) levels strongly predict inflammatory diseases such as obesity and tissue damage. We wanted to study the CRP in plasma and tissue in morbidly obese patients before and after surgery and relate it with the expression of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in tissues.

Methods

We analyzed CRP concentration in plasma, adipose and liver, and the expression of IL-6 and TNF-α, in those tissues, in 34 morbidly obese patients before and 1, 6 and 12 months after gastric bypass.

Results

Morbidly obese had a greater amount of CRP in plasma (3 times) and tissues (21, 5 and 7 times more in liver, subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT), respectively) than control subjects. The expression of IL-6 in SAT showed a similar profile to plasma and SAT CRP in both obese patients and after weight loss, despite no significant correlation was found. We were only able to detect IL-6 in the liver of a subset of patients. The expression of TNF-α after surgery showed a no significant slight tendency to decrease in SAT with weight loss, but in the liver, we did not observe any change.

Conclusion

IL-6 in SAT, but not in liver, seems to be more closely related to plasma and tissue CRP than TNF-α in both obese patients and after weight loss. Plasma CRP protein perfectly reflects the decrease in inflammation and improves with weight loss in the tissues.

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Title: Only C-Reactive Protein, but not TNF-α or IL6, Reflects the Improvement in Inflammation after Bariatric Surgery
Authors: Eva Pardina
Roser Ferrer
Juan Antonio Baena-Fustegueras
Joaquín Rivero
Albert Lecube
Jose Manuel Fort
Víctor Vargas
Roberto Catalán
Julia Peinado-Onsurbe
Publication date: 01-01-2012
Publisher: Springer-Verlag
Published in: Obesity Surgery / Issue 1/2012
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-011-0546-3

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Only C-Reactive Protein, but not TNF-α or IL6, Reflects the Improvement in Inflammation after Bariatric Surgery

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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