Skip to main content
Top
Published in: Obesity Surgery 12/2011

01-12-2011 | Clinical Research

Biliopancreatic Diversion with Roux-en-Y Gastric Bypass and Long Limbs: Advances in Surgical Treatment for Super-obesity

Authors: Fotis Kalfarentzos, George Skroubis, Stavros Karamanakos, Marianna Argentou, Nancy Mead, Ioannis Kehagias, Theodore K. Alexandrides

Published in: Obesity Surgery | Issue 12/2011

Login to get access

Abstract

Background

Over the past 14 years, we have used different malabsorptive bariatric operations to treat super-obesity. We compared the efficacy and safety of our preferred procedure for the last 8 years with previous methods used in super-obese.

Methods

Our first procedure was distal Roux-en-Y gastric bypass (distal RYGBP) (gastric pouch 15 ± 5 mL, 80 cm biliopancreatic limb, 100 cm common limb [CL]). The second was distal RYGBP with short alimentary limb (distal RYGBP-sAL) (gastric pouch 15 ± 10 mL, alimentary limb [AL] 250 cm, CL 100 cm). Our preferred procedure for the past 8 years has been biliopancreatic diversion with RYGB and long limbs (BPD-RYGB-LL) (gastric pouch 40 ± 10 mL, AL 400 cm, CL 100 cm).

Results

Seventy-five patients underwent distal RYGBP, 44 distal RYGBP-sAL, and 841 BPD-RYGB-LL. Eight years postoperatively, the mean BMIs were 39.0, 29.4, and 29.2, respectively. The greatest reduction of 47.6% was achieved with BPD-RYGB-LL (distal RYGBP 30.6%; distal RYGBP-sAL 43.1%). Mean excess weight loss was 51.3% for distal RYGBP, 76.5% for distal RYGBP-sAL, and 80.9% for BPD-RYGB-LL. Six patients died at the early postoperative period. Sixteen patients died during the first eight postoperative years, of whom significantly more were after distal RYGBP-sAL (P = 0.0003). Complications were significantly more frequent after distal RYGBP-sAL (P = 0.001). All procedures led to rapid and sustained resolution of major comorbidities in almost all patients affected. Metabolic and nutritional deficiencies were similar and manageable.

Conclusions

Our variant of biliopancreatic diversion (BPD-RYGB-LL) results in substantial and sustained weight loss in super-obese, without compromising safety.
Literature
1.
go back to reference Larrad-Jimenez A, Diaz-Guerra CS, de Cuadros BP, et al. Short-, mid- and long-term results of Larrad biliopancreatic diversion. Obes Surg. 2007;17:202–10.PubMedCrossRef Larrad-Jimenez A, Diaz-Guerra CS, de Cuadros BP, et al. Short-, mid- and long-term results of Larrad biliopancreatic diversion. Obes Surg. 2007;17:202–10.PubMedCrossRef
3.
go back to reference Bult MJ, van Dalen T, Muller AF. Surgical treatment of obesity. Eur J Endocrinol. 2008;158:135–45.PubMedCrossRef Bult MJ, van Dalen T, Muller AF. Surgical treatment of obesity. Eur J Endocrinol. 2008;158:135–45.PubMedCrossRef
4.
go back to reference Mason EE, Ito C. Gastric bypass in obesity. Surg Clin N Am. 1967;47:1345–51.PubMed Mason EE, Ito C. Gastric bypass in obesity. Surg Clin N Am. 1967;47:1345–51.PubMed
5.
go back to reference Scopinaro N, Gianetta E, Civalleri D, et al. Bilio-pancreatic bypass for obesity: II. Initial experience in man. Br J Surg. 1979;66:618–20.PubMedCrossRef Scopinaro N, Gianetta E, Civalleri D, et al. Bilio-pancreatic bypass for obesity: II. Initial experience in man. Br J Surg. 1979;66:618–20.PubMedCrossRef
6.
go back to reference Maggard MA, Shugarman LR, Suttorp M, et al. Meta-analysis: surgical treatment of obesity. Ann Intern Med. 2005;142:547–59.PubMed Maggard MA, Shugarman LR, Suttorp M, et al. Meta-analysis: surgical treatment of obesity. Ann Intern Med. 2005;142:547–59.PubMed
7.
go back to reference Brolin RE. Comment on: five-year outcome with gastric bypass: Roux limb length makes a difference. Surg Obes Relat Dis. 2009;5:247–9.CrossRef Brolin RE. Comment on: five-year outcome with gastric bypass: Roux limb length makes a difference. Surg Obes Relat Dis. 2009;5:247–9.CrossRef
9.
go back to reference Marceau P, Hould FS, Simard S, et al. Biliopancreatic diversion with duodenal switch. World J Surg. 1998;22:947–54.PubMedCrossRef Marceau P, Hould FS, Simard S, et al. Biliopancreatic diversion with duodenal switch. World J Surg. 1998;22:947–54.PubMedCrossRef
10.
go back to reference Marceau P, Biron S, Hould FS, et al. Duodenal switch: long-term results. Obes Surg. 2007;17:1421–30.PubMedCrossRef Marceau P, Biron S, Hould FS, et al. Duodenal switch: long-term results. Obes Surg. 2007;17:1421–30.PubMedCrossRef
11.
go back to reference Cowan G, Buffington C, Hiler ML. Enteric limb lenghts in bariatric surgery. In: Deitel M, Cowan G, editors. Update: surgery for the morbidly obese patient. Toronto: FD-Communications; 1998. p. 267–76. Cowan G, Buffington C, Hiler ML. Enteric limb lenghts in bariatric surgery. In: Deitel M, Cowan G, editors. Update: surgery for the morbidly obese patient. Toronto: FD-Communications; 1998. p. 267–76.
12.
go back to reference Sauerland S, Angrisani L, Belachew M, et al. Obesity surgery: evidence-based guidelines of the European Association for Endoscopic Surgery (EAES). Surg Endosc. 2005;19:200–21.PubMedCrossRef Sauerland S, Angrisani L, Belachew M, et al. Obesity surgery: evidence-based guidelines of the European Association for Endoscopic Surgery (EAES). Surg Endosc. 2005;19:200–21.PubMedCrossRef
13.
go back to reference Murr MM, Balsiger BM, Kennedy FP, et al. Malabsorptive procedures for severe obesity: comparison of pancreaticobiliary bypass and very very long limb Roux-en-Y gastric bypass. J Gastrointest Surg. 1999;3:607–12.PubMedCrossRef Murr MM, Balsiger BM, Kennedy FP, et al. Malabsorptive procedures for severe obesity: comparison of pancreaticobiliary bypass and very very long limb Roux-en-Y gastric bypass. J Gastrointest Surg. 1999;3:607–12.PubMedCrossRef
14.
go back to reference Choban PS, Flancbaum L. The effect of Roux limb lengths on outcome after Roux-en-Y gastric bypass: a prospective, randomized clinical trial. Obes Surg. 2002;12:540–5.PubMedCrossRef Choban PS, Flancbaum L. The effect of Roux limb lengths on outcome after Roux-en-Y gastric bypass: a prospective, randomized clinical trial. Obes Surg. 2002;12:540–5.PubMedCrossRef
15.
go back to reference Christou NV, Look D, Maclean LD. Weight gain after short- and long-limb gastric bypass in patients followed for longer than 10 years. Ann Surg. 2006;244:734–40.PubMedCrossRef Christou NV, Look D, Maclean LD. Weight gain after short- and long-limb gastric bypass in patients followed for longer than 10 years. Ann Surg. 2006;244:734–40.PubMedCrossRef
16.
go back to reference Sugerman HJ, Kellum JM, DeMaria EJ. Conversion of proximal to distal gastric bypass for failed gastric bypass for superobesity. J Gastrointest Surg. 1997;1:517–24.PubMedCrossRef Sugerman HJ, Kellum JM, DeMaria EJ. Conversion of proximal to distal gastric bypass for failed gastric bypass for superobesity. J Gastrointest Surg. 1997;1:517–24.PubMedCrossRef
17.
go back to reference Brolin RE, LaMarca LB, Kenler HA, et al. Malabsorptive gastric bypass in patients with superobesity. J Gastrointest Surg. 2002;6:195–203.PubMedCrossRef Brolin RE, LaMarca LB, Kenler HA, et al. Malabsorptive gastric bypass in patients with superobesity. J Gastrointest Surg. 2002;6:195–203.PubMedCrossRef
18.
go back to reference Stefanidis D, Kuwada TS, Gersin KS. The importance of the length of the limbs for gastric bypass patients—an evidence-based review. Obes Surg. 2011;21:119–24.PubMedCrossRef Stefanidis D, Kuwada TS, Gersin KS. The importance of the length of the limbs for gastric bypass patients—an evidence-based review. Obes Surg. 2011;21:119–24.PubMedCrossRef
19.
go back to reference Gleysteen JJ. Five-year outcome with gastric bypass: Roux limb length makes a difference. Surg Obes Relat Dis. 2009;5:242–7.PubMedCrossRef Gleysteen JJ. Five-year outcome with gastric bypass: Roux limb length makes a difference. Surg Obes Relat Dis. 2009;5:242–7.PubMedCrossRef
20.
go back to reference MacLean LD, Rhode BM, Nohr CW. Long- or short-limb gastric bypass? J Gastrointest Surg. 2001;5:525–30.PubMedCrossRef MacLean LD, Rhode BM, Nohr CW. Long- or short-limb gastric bypass? J Gastrointest Surg. 2001;5:525–30.PubMedCrossRef
21.
go back to reference Kalfarentzos F, Dimakopoulos A, Kehagias I, et al. Vertical banded gastroplasty versus standard or distal Roux-en-Y gastric bypass based on specific selection criteria in the morbidly obese: preliminary results. Obes Surg. 1999;9:433–42.PubMedCrossRef Kalfarentzos F, Dimakopoulos A, Kehagias I, et al. Vertical banded gastroplasty versus standard or distal Roux-en-Y gastric bypass based on specific selection criteria in the morbidly obese: preliminary results. Obes Surg. 1999;9:433–42.PubMedCrossRef
22.
go back to reference Kalfarentzos F, Papadoulas S, Skroubis G, et al. Prospective evaluation of biliopancreatic diversion with Roux-en-Y gastric bypass in the super obese. J Gastrointest Surg. 2004;8:479–88.PubMedCrossRef Kalfarentzos F, Papadoulas S, Skroubis G, et al. Prospective evaluation of biliopancreatic diversion with Roux-en-Y gastric bypass in the super obese. J Gastrointest Surg. 2004;8:479–88.PubMedCrossRef
23.
go back to reference Skroubis G, Sakellaropoulos G, Pouggouras K, et al. Comparison of nutritional deficiencies after Roux-en-Y gastric bypass and after biliopancreatic diversion with Roux-en-Y gastric bypass. Obes Surg. 2002;12:551–8.PubMedCrossRef Skroubis G, Sakellaropoulos G, Pouggouras K, et al. Comparison of nutritional deficiencies after Roux-en-Y gastric bypass and after biliopancreatic diversion with Roux-en-Y gastric bypass. Obes Surg. 2002;12:551–8.PubMedCrossRef
24.
go back to reference Petsas T, Kraniotis P, Spyropoulos C, et al. The role of CT-guided percutaneous gastrostomy in patients with clinically severe obesity presenting with complications after bariatric surgery. Surg Laparosc Endosc Percutan Tech. 2010;20:299–305.PubMedCrossRef Petsas T, Kraniotis P, Spyropoulos C, et al. The role of CT-guided percutaneous gastrostomy in patients with clinically severe obesity presenting with complications after bariatric surgery. Surg Laparosc Endosc Percutan Tech. 2010;20:299–305.PubMedCrossRef
25.
go back to reference Skroubis G, Karamanakos S, Sakellaropoulos G, et al. Comparison of early and late complications after various bariatric procedures: incidence and treatment during 15 years at a single institution. World J Surg. 2011;35:93–101.PubMedCrossRef Skroubis G, Karamanakos S, Sakellaropoulos G, et al. Comparison of early and late complications after various bariatric procedures: incidence and treatment during 15 years at a single institution. World J Surg. 2011;35:93–101.PubMedCrossRef
26.
go back to reference Spyropoulos C, Bakellas G, Skroubis G, et al. A prospective evaluation of a variant of biliopancreatic diversion with Roux-en-Y reconstruction in mega-obese patients (BMI > or =70 kg/m(2)). Obes Surg. 2008;18:803–9.PubMedCrossRef Spyropoulos C, Bakellas G, Skroubis G, et al. A prospective evaluation of a variant of biliopancreatic diversion with Roux-en-Y reconstruction in mega-obese patients (BMI > or =70 kg/m(2)). Obes Surg. 2008;18:803–9.PubMedCrossRef
27.
go back to reference Skroubis G, Anesidis S, Kehagias I, et al. Roux-en-Y gastric bypass versus a variant of biliopancreatic diversion in a non-superobese population: prospective comparison of the efficacy and the incidence of metabolic deficiencies. Obes Surg. 2006;16:488–95.PubMedCrossRef Skroubis G, Anesidis S, Kehagias I, et al. Roux-en-Y gastric bypass versus a variant of biliopancreatic diversion in a non-superobese population: prospective comparison of the efficacy and the incidence of metabolic deficiencies. Obes Surg. 2006;16:488–95.PubMedCrossRef
28.
go back to reference Kalfarentzos F, Skroubis G, Kehagias I, et al. A prospective comparison of vertical banded gastroplasty and Roux-en-Y gastric bypass in a non-superobese population. Obes Surg. 2006;16:151–8.PubMedCrossRef Kalfarentzos F, Skroubis G, Kehagias I, et al. A prospective comparison of vertical banded gastroplasty and Roux-en-Y gastric bypass in a non-superobese population. Obes Surg. 2006;16:151–8.PubMedCrossRef
29.
go back to reference Brolin RE, Kenler HA, Gorman JH, et al. Long-limb gastric bypass in the superobese. A prospective randomized study. Ann Surg. 1992;215:387–95.PubMedCrossRef Brolin RE, Kenler HA, Gorman JH, et al. Long-limb gastric bypass in the superobese. A prospective randomized study. Ann Surg. 1992;215:387–95.PubMedCrossRef
30.
go back to reference Kellum JM, Chikunguwo SM, Maher JW, et al. Long-term results of malabsorptive distal Roux-en-Y gastric bypass in superobese patients. Surg Obes Relat Dis. 2011;7:189–93.PubMedCrossRef Kellum JM, Chikunguwo SM, Maher JW, et al. Long-term results of malabsorptive distal Roux-en-Y gastric bypass in superobese patients. Surg Obes Relat Dis. 2011;7:189–93.PubMedCrossRef
31.
go back to reference Brolin RE. Comment on: long-term results of malabsorptive distal Roux-en-Y gastric bypass in superobese patients. Surg Obes Relat Dis. 2011;7:193–4.PubMedCrossRef Brolin RE. Comment on: long-term results of malabsorptive distal Roux-en-Y gastric bypass in superobese patients. Surg Obes Relat Dis. 2011;7:193–4.PubMedCrossRef
32.
go back to reference Scopinaro N. Biliopancreatic diversion: mechanisms of action and long-term results. Obes Surg. 2006;16:683–9.PubMedCrossRef Scopinaro N. Biliopancreatic diversion: mechanisms of action and long-term results. Obes Surg. 2006;16:683–9.PubMedCrossRef
33.
go back to reference Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292:1724–37.PubMedCrossRef Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292:1724–37.PubMedCrossRef
34.
go back to reference Nelson WK, Fatima J, Houghton SG, et al. The malabsorptive very, very long limb Roux-en-Y gastric bypass for super obesity: results in 257 patients. Surgery. 2006;140:517–22.PubMedCrossRef Nelson WK, Fatima J, Houghton SG, et al. The malabsorptive very, very long limb Roux-en-Y gastric bypass for super obesity: results in 257 patients. Surgery. 2006;140:517–22.PubMedCrossRef
35.
go back to reference Prachand VN, Davee RT, Alverdy JC. Duodenal switch provides superior weight loss in the super-obese (BMI > or =50 kg/m2) compared with gastric bypass. Ann Surg. 2006;244:611–9.PubMed Prachand VN, Davee RT, Alverdy JC. Duodenal switch provides superior weight loss in the super-obese (BMI > or =50 kg/m2) compared with gastric bypass. Ann Surg. 2006;244:611–9.PubMed
36.
go back to reference Buchwald H, Estok R, Fahrbach K, et al. Trends in mortality in bariatric surgery: a systematic review and meta-analysis. Surgery. 2007;142:621–32.PubMedCrossRef Buchwald H, Estok R, Fahrbach K, et al. Trends in mortality in bariatric surgery: a systematic review and meta-analysis. Surgery. 2007;142:621–32.PubMedCrossRef
Metadata
Title
Biliopancreatic Diversion with Roux-en-Y Gastric Bypass and Long Limbs: Advances in Surgical Treatment for Super-obesity
Authors
Fotis Kalfarentzos
George Skroubis
Stavros Karamanakos
Marianna Argentou
Nancy Mead
Ioannis Kehagias
Theodore K. Alexandrides
Publication date
01-12-2011
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 12/2011
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-011-0532-9

Other articles of this Issue 12/2011

Obesity Surgery 12/2011 Go to the issue