Skip to main content
Top
Published in: Obesity Surgery 12/2011

01-12-2011 | Clinical Research

Is Routine Cholecystectomy Justified in Severely Obese Patients Undergoing a Laparoscopic Roux-en-Y Gastric Bypass Procedure? A Comparative Cohort Study

Authors: Ignazio Tarantino, Renè Warschkow, Thomas Steffen, Philipp Bisang, Bernd Schultes, Martin Thurnheer

Published in: Obesity Surgery | Issue 12/2011

Login to get access

Abstract

Background

The aim of the present study was to evaluate the risks and benefits of concurrent prophylactic cholecystectomy (CPC) during laparoscopic Roux-en-Y gastric bypass (LRYGB).

Methods

From December 2000 to November 2006, CPC during LRYGB was only performed in the presence of gallbladder pathology (n = 140). Beginning in December 2006, CPC was performed during all LRYGB procedures (n = 134). Exclusion criteria were open bypass procedure, previous bariatric surgery other than gastric banding, and previous cholecystectomy (CCE) or necessary concurrent CCE due to gallbladder pathology.

Results

During a median follow-up of 3.1 years, 26 (18.6%; 95% CI, 12.9–25.9%) of 140 patients without CPC subsequently required a CCE, leading to a gallbladder disease-free survival rate at 5 years of 77.4% (95% CI, 67.3–87.6%). Multivariate analysis identified a distal LRYGB and excess weight loss of >75% at 2 years to be significant risk factors for the development of biliary complications while a preoperative BMI > 50 m2/kg was protective. In the second series, prophylactic CCE was not associated with prolonged hospitalization or operative time. The postoperative complications were not related to the CPC.

Conclusions

The present data indicate that a substantial number of patients develop gallbladder complications after LRYGB. Furthermore, CPC can safely be performed during LRYGB. Based on these findings, CPC should be considered a reasonable approach in severely obese patients undergoing LRYGB.
Literature
1.
go back to reference Uy MC, Talingdan-Te MC, Espinosa WZ, et al. Ursodeoxycholic acid in the prevention of gallstone formation after bariatric surgery: a meta-analysis. Obes Surg. 2008;18:1532–8.PubMedCrossRef Uy MC, Talingdan-Te MC, Espinosa WZ, et al. Ursodeoxycholic acid in the prevention of gallstone formation after bariatric surgery: a meta-analysis. Obes Surg. 2008;18:1532–8.PubMedCrossRef
2.
go back to reference Nougou A, Suter M. Almost routine prophylactic cholecystectomy during laparoscopic gastric bypass is safe. Obes Surg. 2008;18:535–9.PubMedCrossRef Nougou A, Suter M. Almost routine prophylactic cholecystectomy during laparoscopic gastric bypass is safe. Obes Surg. 2008;18:535–9.PubMedCrossRef
3.
go back to reference Wudel Jr LJ, Wright JK, Debelak JP, et al. Prevention of gallstone formation in morbidly obese patients undergoing rapid weight loss: results of a randomized controlled pilot study. J Surg Res. 2002;102:50–6.PubMedCrossRef Wudel Jr LJ, Wright JK, Debelak JP, et al. Prevention of gallstone formation in morbidly obese patients undergoing rapid weight loss: results of a randomized controlled pilot study. J Surg Res. 2002;102:50–6.PubMedCrossRef
4.
go back to reference Dittrick GW, Thompson JS, Campos D, et al. Gallbladder pathology in morbid obesity. Obes Surg. 2005;15:238–42.PubMedCrossRef Dittrick GW, Thompson JS, Campos D, et al. Gallbladder pathology in morbid obesity. Obes Surg. 2005;15:238–42.PubMedCrossRef
5.
6.
go back to reference Shiffman ML, Sugerman HJ, Kellum JH, et al. Gallstones in patients with morbid obesity. Relationship to body weight, weight loss and gallbladder bile cholesterol solubility. Int J Obes Relat Metab Disord. 1993;17:153–8.PubMed Shiffman ML, Sugerman HJ, Kellum JH, et al. Gallstones in patients with morbid obesity. Relationship to body weight, weight loss and gallbladder bile cholesterol solubility. Int J Obes Relat Metab Disord. 1993;17:153–8.PubMed
7.
go back to reference Ahmed AR, O'Malley W, Johnson J, et al. Cholecystectomy during laparoscopic gastric bypass has no effect on duration of hospital stay. Obes Surg. 2007;17:1075–9.PubMedCrossRef Ahmed AR, O'Malley W, Johnson J, et al. Cholecystectomy during laparoscopic gastric bypass has no effect on duration of hospital stay. Obes Surg. 2007;17:1075–9.PubMedCrossRef
8.
go back to reference Iglezias Brandao de Oliveira C, Adami Chaim E, da Silva BB. Impact of rapid weight reduction on risk of cholelithiasis after bariatric surgery. Obes Surg. 2003;13:625–8.PubMedCrossRef Iglezias Brandao de Oliveira C, Adami Chaim E, da Silva BB. Impact of rapid weight reduction on risk of cholelithiasis after bariatric surgery. Obes Surg. 2003;13:625–8.PubMedCrossRef
9.
go back to reference Shiffman ML, Sugerman HJ, Kellum JM, et al. Gallstone formation after rapid weight loss: a prospective study in patients undergoing gastric bypass surgery for treatment of morbid obesity. Am J Gastroenterol. 1991;86:1000–5.PubMed Shiffman ML, Sugerman HJ, Kellum JM, et al. Gallstone formation after rapid weight loss: a prospective study in patients undergoing gastric bypass surgery for treatment of morbid obesity. Am J Gastroenterol. 1991;86:1000–5.PubMed
10.
go back to reference Everhart JE. Contributions of obesity and weight loss to gallstone disease. Ann Intern Med. 1993;119:1029–35.PubMed Everhart JE. Contributions of obesity and weight loss to gallstone disease. Ann Intern Med. 1993;119:1029–35.PubMed
11.
go back to reference Sugerman HJ, Brewer WH, Shiffman ML, et al. A multicenter, placebo-controlled, randomized, double-blind, prospective trial of prophylactic ursodiol for the prevention of gallstone formation following gastric-bypass-induced rapid weight loss. Am J Surg. 1995;169:91–6. discussion 6–7.PubMedCrossRef Sugerman HJ, Brewer WH, Shiffman ML, et al. A multicenter, placebo-controlled, randomized, double-blind, prospective trial of prophylactic ursodiol for the prevention of gallstone formation following gastric-bypass-induced rapid weight loss. Am J Surg. 1995;169:91–6. discussion 6–7.PubMedCrossRef
12.
go back to reference Schmidt JH, Hocking MP, Rout WR, et al. The case for prophylactic cholecystectomy concomitant with gastric restriction for morbid obesity. Am Surg. 1988;54:269–72.PubMed Schmidt JH, Hocking MP, Rout WR, et al. The case for prophylactic cholecystectomy concomitant with gastric restriction for morbid obesity. Am Surg. 1988;54:269–72.PubMed
13.
go back to reference Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292:1724–37.PubMedCrossRef Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292:1724–37.PubMedCrossRef
14.
go back to reference Worobetz LJ, Inglis FG, Shaffer EA. The effect of ursodeoxycholic acid therapy on gallstone formation in the morbidly obese during rapid weight loss. Am J Gastroenterol. 1993;88:1705–10.PubMed Worobetz LJ, Inglis FG, Shaffer EA. The effect of ursodeoxycholic acid therapy on gallstone formation in the morbidly obese during rapid weight loss. Am J Gastroenterol. 1993;88:1705–10.PubMed
15.
go back to reference Bastouly M, Arasaki CH, Ferreira JB, et al. Early changes in postprandial gallbladder emptying in morbidly obese patients undergoing Roux-en-Y gastric bypass: correlation with the occurrence of biliary sludge and gallstones. Obes Surg. 2009;19:22–8.PubMedCrossRef Bastouly M, Arasaki CH, Ferreira JB, et al. Early changes in postprandial gallbladder emptying in morbidly obese patients undergoing Roux-en-Y gastric bypass: correlation with the occurrence of biliary sludge and gallstones. Obes Surg. 2009;19:22–8.PubMedCrossRef
16.
go back to reference Hamad GG, Ikramuddin S, Gourash WF, et al. Elective cholecystectomy during laparoscopic Roux-en-Y gastric bypass: is it worth the wait? Obes Surg. 2003;13:76–81.PubMedCrossRef Hamad GG, Ikramuddin S, Gourash WF, et al. Elective cholecystectomy during laparoscopic Roux-en-Y gastric bypass: is it worth the wait? Obes Surg. 2003;13:76–81.PubMedCrossRef
17.
go back to reference Calhoun R, Willbanks O. Coexistence of gallbladder disease and morbid obesity. Am J Surg. 1987;154:655–8.PubMedCrossRef Calhoun R, Willbanks O. Coexistence of gallbladder disease and morbid obesity. Am J Surg. 1987;154:655–8.PubMedCrossRef
18.
go back to reference Aidonopoulos AP, Papavramidis ST, Zaraboukas TG, et al. Gallbladder findings after cholecystectomy in morbidly obese patients. Obes Surg. 1994;4:8–12.PubMedCrossRef Aidonopoulos AP, Papavramidis ST, Zaraboukas TG, et al. Gallbladder findings after cholecystectomy in morbidly obese patients. Obes Surg. 1994;4:8–12.PubMedCrossRef
19.
go back to reference Seinige UL, Sataloff DM, Lieber CP, et al. Gallbladder disease in the morbidly obese patient. Obes Surg. 1991;1:51–6.PubMedCrossRef Seinige UL, Sataloff DM, Lieber CP, et al. Gallbladder disease in the morbidly obese patient. Obes Surg. 1991;1:51–6.PubMedCrossRef
20.
go back to reference Fobi M, Lee H, Igwe D, et al. Prophylactic cholecystectomy with gastric bypass operation: incidence of gallbladder disease. Obes Surg. 2002;12:350–3.PubMedCrossRef Fobi M, Lee H, Igwe D, et al. Prophylactic cholecystectomy with gastric bypass operation: incidence of gallbladder disease. Obes Surg. 2002;12:350–3.PubMedCrossRef
21.
go back to reference Villegas L, Schneider B, Provost D, et al. Is routine cholecystectomy required during laparoscopic gastric bypass? Obes Surg. 2004;14:206–11.PubMedCrossRef Villegas L, Schneider B, Provost D, et al. Is routine cholecystectomy required during laparoscopic gastric bypass? Obes Surg. 2004;14:206–11.PubMedCrossRef
22.
go back to reference Escalona A, Boza C, Munoz R, et al. Routine preoperative ultrasonography and selective cholecystectomy in laparoscopic Roux-en-Y gastric bypass. Why not? Obes Surg. 2008;18:47–51.PubMedCrossRef Escalona A, Boza C, Munoz R, et al. Routine preoperative ultrasonography and selective cholecystectomy in laparoscopic Roux-en-Y gastric bypass. Why not? Obes Surg. 2008;18:47–51.PubMedCrossRef
23.
go back to reference Tucker ON, Fajnwaks P, Szomstein S, et al. Is concomitant cholecystectomy necessary in obese patients undergoing laparoscopic gastric bypass surgery? Surg Endosc. 2008;22:2450–4.PubMedCrossRef Tucker ON, Fajnwaks P, Szomstein S, et al. Is concomitant cholecystectomy necessary in obese patients undergoing laparoscopic gastric bypass surgery? Surg Endosc. 2008;22:2450–4.PubMedCrossRef
24.
go back to reference Swartz DE, Felix EL. Elective cholecystectomy after Roux-en-Y gastric bypass: why should asymptomatic gallstones be treated differently in morbidly obese patients? Surg Obes Relat Dis. 2005;1:555–60.PubMedCrossRef Swartz DE, Felix EL. Elective cholecystectomy after Roux-en-Y gastric bypass: why should asymptomatic gallstones be treated differently in morbidly obese patients? Surg Obes Relat Dis. 2005;1:555–60.PubMedCrossRef
25.
go back to reference NIH conference. Gastrointestinal surgery for severe obesity. Consensus Development Conference Panel. Ann Intern Med. 1991;115:956–61. NIH conference. Gastrointestinal surgery for severe obesity. Consensus Development Conference Panel. Ann Intern Med. 1991;115:956–61.
26.
go back to reference Consensus sur le traitment de l'obésité en Suisse. Schweiz Med Wochenschr. 1999;129:4–205. Consensus sur le traitment de l'obésité en Suisse. Schweiz Med Wochenschr. 1999;129:4–205.
27.
go back to reference Austin PC, Tu J. Bootstrap methods for developing predictive models. Am Stat. 2004;131–7. Austin PC, Tu J. Bootstrap methods for developing predictive models. Am Stat. 2004;131–7.
28.
go back to reference Papasavas PK, Gagne DJ, Ceppa FA, et al. Routine gallbladder screening not necessary in patients undergoing laparoscopic Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2006;2:41–6. discussion 6–7.PubMedCrossRef Papasavas PK, Gagne DJ, Ceppa FA, et al. Routine gallbladder screening not necessary in patients undergoing laparoscopic Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2006;2:41–6. discussion 6–7.PubMedCrossRef
29.
go back to reference Patel KR, White SC, Tejirian T, et al. Gallbladder management during laparoscopic Roux-en-Y gastric bypass surgery: routine preoperative screening for gallstones and postoperative prophylactic medical treatment are not necessary. Am Surg. 2006;72:857–61.PubMed Patel KR, White SC, Tejirian T, et al. Gallbladder management during laparoscopic Roux-en-Y gastric bypass surgery: routine preoperative screening for gallstones and postoperative prophylactic medical treatment are not necessary. Am Surg. 2006;72:857–61.PubMed
30.
go back to reference Taylor J, Leitman IM, Horowitz M. Is routine cholecystectomy necessary at the time of Roux-en-Y gastric bypass? Obes Surg. 2006;16:759–61.PubMedCrossRef Taylor J, Leitman IM, Horowitz M. Is routine cholecystectomy necessary at the time of Roux-en-Y gastric bypass? Obes Surg. 2006;16:759–61.PubMedCrossRef
31.
go back to reference Portenier DD, Grant JP, Blackwood HS, et al. Expectant management of the asymptomatic gallbladder at Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2007;3:476–9.PubMedCrossRef Portenier DD, Grant JP, Blackwood HS, et al. Expectant management of the asymptomatic gallbladder at Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2007;3:476–9.PubMedCrossRef
32.
go back to reference Caruana JA, McCabe MN, Smith AD, et al. Incidence of symptomatic gallstones after gastric bypass: is prophylactic treatment really necessary? Surg Obes Relat Dis. 2005;1:564–7. discussion 7–8.PubMedCrossRef Caruana JA, McCabe MN, Smith AD, et al. Incidence of symptomatic gallstones after gastric bypass: is prophylactic treatment really necessary? Surg Obes Relat Dis. 2005;1:564–7. discussion 7–8.PubMedCrossRef
33.
go back to reference Martinez J, Guerrero L, Byers P, et al. Endoscopic retrograde cholangiopancreatography and gastroduodenoscopy after Roux-en-Y gastric bypass. Surg Endosc. 2006;20:1548–50.PubMedCrossRef Martinez J, Guerrero L, Byers P, et al. Endoscopic retrograde cholangiopancreatography and gastroduodenoscopy after Roux-en-Y gastric bypass. Surg Endosc. 2006;20:1548–50.PubMedCrossRef
34.
go back to reference Mosler P, Fogel EL. Massive subcutaneous emphysema after attempted endoscopic retrograde cholangiopancreatography in a patient with a history of bariatric gastric bypass surgery. Endoscopy. 2007;39 Suppl 1:E155.PubMedCrossRef Mosler P, Fogel EL. Massive subcutaneous emphysema after attempted endoscopic retrograde cholangiopancreatography in a patient with a history of bariatric gastric bypass surgery. Endoscopy. 2007;39 Suppl 1:E155.PubMedCrossRef
35.
go back to reference Fuller W, Rasmussen JJ, Ghosh J, et al. Is routine cholecystectomy indicated for asymptomatic cholelithiasis in patients undergoing gastric bypass? Obes Surg. 2007;17:747–51.PubMedCrossRef Fuller W, Rasmussen JJ, Ghosh J, et al. Is routine cholecystectomy indicated for asymptomatic cholelithiasis in patients undergoing gastric bypass? Obes Surg. 2007;17:747–51.PubMedCrossRef
36.
go back to reference Scopinaro N, Gianetta E, Civalleri D, et al. Two years of clinical experience with biliopancreatic bypass for obesity. Am J Clin Nutr. 1980;33:506–14.PubMed Scopinaro N, Gianetta E, Civalleri D, et al. Two years of clinical experience with biliopancreatic bypass for obesity. Am J Clin Nutr. 1980;33:506–14.PubMed
Metadata
Title
Is Routine Cholecystectomy Justified in Severely Obese Patients Undergoing a Laparoscopic Roux-en-Y Gastric Bypass Procedure? A Comparative Cohort Study
Authors
Ignazio Tarantino
Renè Warschkow
Thomas Steffen
Philipp Bisang
Bernd Schultes
Martin Thurnheer
Publication date
01-12-2011
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 12/2011
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-011-0495-x

Other articles of this Issue 12/2011

Obesity Surgery 12/2011 Go to the issue