Skip to main content
Top
Published in: Obesity Surgery 12/2011

01-12-2011 | Case Report

The Importance of Methylmalonic Acid Dosage on the Assessment of Patients with Neurological Manifestations Following Bariatric Surgery

Authors: Camilo Vieira, Camila Cosmo, Rita Lucena

Published in: Obesity Surgery | Issue 12/2011

Login to get access

Abstract

Vitamin B12 or cyanocobalamin is an important substance that is included in several metabolic pathways. Its deficiency is a common event after bariatric surgery, decreasing the vitamin B12 absorption after almost all of the stomach and duodenum are eliminated from the digestion process. Neurological manifestations of cyanocobalamin deficiency are not uncommon. We report a case of a young woman who developed ataxia, weakness and peripheral neuropathy after bariatric surgery, but with normal value of vitamin B12 dosage. For the diagnosis, it was necessary to dose methylmalonic acid. We discuss the importance of methylmalonic acid dosage after bariatric surgery in patients who present suspect of cyanocobalamin deficiency with normal values of this vitamin and the role of proton pump inhibitor use and vitamin supplementation in patients with early neurological presentation.
Literature
1.
go back to reference Carmel R, Green R, Rosenblatt DS, et al. Update on cobalamin, folate, and homocysteine. Hematology Am Soc Hematol Educ Program 2003;62–81 Carmel R, Green R, Rosenblatt DS, et al. Update on cobalamin, folate, and homocysteine. Hematology Am Soc Hematol Educ Program 2003;62–81
2.
go back to reference Allen RH, Stabler SP, Savage DG, et al. Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency. FASEB J. 1993;7:1344–53.PubMed Allen RH, Stabler SP, Savage DG, et al. Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency. FASEB J. 1993;7:1344–53.PubMed
3.
go back to reference Stabler SP, Allen RH, Savage DG, et al. Clinical spectrum and diagnosis of cobalamin deficiency. Blood. 1990;76:871–81.PubMed Stabler SP, Allen RH, Savage DG, et al. Clinical spectrum and diagnosis of cobalamin deficiency. Blood. 1990;76:871–81.PubMed
4.
go back to reference Snow CF. Laboratory diagnosis of vitamin B12 and folate deficiency: a guide for the primary care physician. Arch Intern Med. 1999;159:1289–98.PubMedCrossRef Snow CF. Laboratory diagnosis of vitamin B12 and folate deficiency: a guide for the primary care physician. Arch Intern Med. 1999;159:1289–98.PubMedCrossRef
5.
go back to reference Morris MS, Jacques PF, Rosenberg IH, et al. Elevated serum methylmalonic acid concentrations are common among elderly Americans. J Nutr. 2002;132:2799–803.PubMed Morris MS, Jacques PF, Rosenberg IH, et al. Elevated serum methylmalonic acid concentrations are common among elderly Americans. J Nutr. 2002;132:2799–803.PubMed
6.
go back to reference Allen LH, Rosado JL, Casterline JE, et al. Vitamin B-12 deficiency and malabsorption are highly prevalent in rural Mexican communities. Am J Clin Nutr. 1995;62:1013–9.PubMed Allen LH, Rosado JL, Casterline JE, et al. Vitamin B-12 deficiency and malabsorption are highly prevalent in rural Mexican communities. Am J Clin Nutr. 1995;62:1013–9.PubMed
7.
go back to reference Diez-Ewald M, Torres-Guerra E, Layrisse M, et al. Prevalence of anemia, iron, folic acid and vitamin B12 deficiency in two Bari Indian communities from western Venezuela. Invest Clin. 1997;38:191–201.PubMed Diez-Ewald M, Torres-Guerra E, Layrisse M, et al. Prevalence of anemia, iron, folic acid and vitamin B12 deficiency in two Bari Indian communities from western Venezuela. Invest Clin. 1997;38:191–201.PubMed
8.
go back to reference Vargas-Ruiz AG, Hernandez-Rivera G, Herrera MF. Prevalence of iron, folate, and vitamin B12 deficiency anemia after laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2008;18:288–93.PubMedCrossRef Vargas-Ruiz AG, Hernandez-Rivera G, Herrera MF. Prevalence of iron, folate, and vitamin B12 deficiency anemia after laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2008;18:288–93.PubMedCrossRef
9.
go back to reference Rhode BM, Arseneau P, Cooper BA, et al. Vitamin B-12 deficiency after gastric surgery for obesity. Am J Clin Nutr. 1996;63:103–9.PubMed Rhode BM, Arseneau P, Cooper BA, et al. Vitamin B-12 deficiency after gastric surgery for obesity. Am J Clin Nutr. 1996;63:103–9.PubMed
10.
go back to reference Halverson JD, Zuckerman GR, Koehler RE, et al. Gastric bypass for morbid obesity: a medical–surgical assessment. Ann Surg. 1981;194:152–60.PubMedCrossRef Halverson JD, Zuckerman GR, Koehler RE, et al. Gastric bypass for morbid obesity: a medical–surgical assessment. Ann Surg. 1981;194:152–60.PubMedCrossRef
11.
go back to reference Amaral JF, Thompson WR, Caldwell MD, et al. Prospective hematologic evaluation of gastric exclusion surgery for morbid obesity. Ann Surg. 1985;201:186–93.PubMedCrossRef Amaral JF, Thompson WR, Caldwell MD, et al. Prospective hematologic evaluation of gastric exclusion surgery for morbid obesity. Ann Surg. 1985;201:186–93.PubMedCrossRef
12.
go back to reference Brolin RE, Gorman JH, Gorman RC, et al. Are vitamin B12 and folate deficiency clinically important after roux-en-Y gastric bypass? J Gastrointest Surg. 1998;2:436–42.PubMedCrossRef Brolin RE, Gorman JH, Gorman RC, et al. Are vitamin B12 and folate deficiency clinically important after roux-en-Y gastric bypass? J Gastrointest Surg. 1998;2:436–42.PubMedCrossRef
13.
go back to reference Alvarez-Leite JI. Nutrient deficiencies secondary to bariatric surgery. Curr Opin Clin Nutr Metab Care. 2004;7:569–75.PubMedCrossRef Alvarez-Leite JI. Nutrient deficiencies secondary to bariatric surgery. Curr Opin Clin Nutr Metab Care. 2004;7:569–75.PubMedCrossRef
14.
go back to reference Parkes E. Nutritional management of patients after bariatric surgery. Am J Med Sci. 2006;331:207–13.PubMedCrossRef Parkes E. Nutritional management of patients after bariatric surgery. Am J Med Sci. 2006;331:207–13.PubMedCrossRef
15.
go back to reference Skroubis G, Sakellaropoulos G, Pouggouras K, et al. Comparison of nutritional deficiencies after Roux-en-Y gastric bypass and after biliopancreatic diversion with Roux-en-Y gastric bypass. Obes Surg. 2002;12:551–8.PubMedCrossRef Skroubis G, Sakellaropoulos G, Pouggouras K, et al. Comparison of nutritional deficiencies after Roux-en-Y gastric bypass and after biliopancreatic diversion with Roux-en-Y gastric bypass. Obes Surg. 2002;12:551–8.PubMedCrossRef
16.
go back to reference Healton EB, Savage DG, Brust JC, et al. Neurologic aspects of cobalamin deficiency. Medicine (Baltimore). 1991;70:229–45. Healton EB, Savage DG, Brust JC, et al. Neurologic aspects of cobalamin deficiency. Medicine (Baltimore). 1991;70:229–45.
17.
go back to reference Kumar S. Recurrent seizures: an unusual manifestation of vitamin B12 deficiency. Neurol India. 2004;52:122–3.PubMed Kumar S. Recurrent seizures: an unusual manifestation of vitamin B12 deficiency. Neurol India. 2004;52:122–3.PubMed
18.
go back to reference Kvittingen EA, Spangen S, Lindemans J, et al. Methionine synthase deficiency without megaloblastic anaemia. Eur J Pediatr. 1997;156:925–30.PubMedCrossRef Kvittingen EA, Spangen S, Lindemans J, et al. Methionine synthase deficiency without megaloblastic anaemia. Eur J Pediatr. 1997;156:925–30.PubMedCrossRef
19.
go back to reference Abarbanel JM, Berginer VM, Osimani A, et al. Neurologic complications after gastric restriction surgery for morbid obesity. Neurology. 1987;37:196–200.PubMed Abarbanel JM, Berginer VM, Osimani A, et al. Neurologic complications after gastric restriction surgery for morbid obesity. Neurology. 1987;37:196–200.PubMed
20.
go back to reference Thaisetthawatkul P, Collazo-Clavell ML, Sarr MG, et al. A controlled study of peripheral neuropathy after bariatric surgery. Neurology. 2004;63:1462–70.PubMed Thaisetthawatkul P, Collazo-Clavell ML, Sarr MG, et al. A controlled study of peripheral neuropathy after bariatric surgery. Neurology. 2004;63:1462–70.PubMed
22.
go back to reference Marcuard SP, Albernaz L, Khazanie PG. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12). Ann Intern Med. 1994;120:211–5.PubMed Marcuard SP, Albernaz L, Khazanie PG. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12). Ann Intern Med. 1994;120:211–5.PubMed
23.
go back to reference Juhasz-Pocsine K, Rudnicki SA, Archer RL, et al. Neurologic complications of gastric bypass surgery for morbid obesity. Neurology. 2007;68:1843–50.PubMedCrossRef Juhasz-Pocsine K, Rudnicki SA, Archer RL, et al. Neurologic complications of gastric bypass surgery for morbid obesity. Neurology. 2007;68:1843–50.PubMedCrossRef
24.
go back to reference Lindenbaum J, Savage DG, Stabler SP, et al. Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations. Am J Hematol. 1990;34:99–107.PubMedCrossRef Lindenbaum J, Savage DG, Stabler SP, et al. Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations. Am J Hematol. 1990;34:99–107.PubMedCrossRef
25.
go back to reference de Mello CF, Begnini J, Jimenez-Bernal RE, et al. Intrastriatal methylmalonic acid administration induces rotational behavior and convulsions through glutamatergic mechanisms. Brain Res. 1996;721:120–5.PubMedCrossRef de Mello CF, Begnini J, Jimenez-Bernal RE, et al. Intrastriatal methylmalonic acid administration induces rotational behavior and convulsions through glutamatergic mechanisms. Brain Res. 1996;721:120–5.PubMedCrossRef
26.
go back to reference Malfatti CR, Royes LF, Francescato L, et al. Intrastriatal methylmalonic acid administration induces convulsions and TBARS production, and alters Na+, K+−ATPase activity in the rat striatum and cerebral cortex. Epilepsia. 2003;44:761–7.PubMedCrossRef Malfatti CR, Royes LF, Francescato L, et al. Intrastriatal methylmalonic acid administration induces convulsions and TBARS production, and alters Na+, K+−ATPase activity in the rat striatum and cerebral cortex. Epilepsia. 2003;44:761–7.PubMedCrossRef
27.
go back to reference Dahele A, Ghosh S. Vitamin B12 deficiency in untreated celiac disease. Am J Gastroenterol. 2001;96:745–50.PubMedCrossRef Dahele A, Ghosh S. Vitamin B12 deficiency in untreated celiac disease. Am J Gastroenterol. 2001;96:745–50.PubMedCrossRef
28.
go back to reference Gultepe M, Ozcan O, Avsar K, et al. Urine methylmalonic acid measurements for the assessment of cobalamin deficiency related to neuropsychiatric disorders. Clin Biochem. 2003;36:275–82.PubMedCrossRef Gultepe M, Ozcan O, Avsar K, et al. Urine methylmalonic acid measurements for the assessment of cobalamin deficiency related to neuropsychiatric disorders. Clin Biochem. 2003;36:275–82.PubMedCrossRef
29.
go back to reference Holleland G, Schneede J, Ueland PM, et al. Cobalamin deficiency in general practice. Assessment of the diagnostic utility and cost-benefit analysis of methylmalonic acid determination in relation to current diagnostic strategies. Clin Chem. 1999;45:189–98.PubMed Holleland G, Schneede J, Ueland PM, et al. Cobalamin deficiency in general practice. Assessment of the diagnostic utility and cost-benefit analysis of methylmalonic acid determination in relation to current diagnostic strategies. Clin Chem. 1999;45:189–98.PubMed
30.
go back to reference Norman EJ. Urinary methylmalonic acid/creatinine ratio defines true tissue cobalamin deficiency. Br J Haematol. 1998;100:614–5. author reply 617–618.PubMedCrossRef Norman EJ. Urinary methylmalonic acid/creatinine ratio defines true tissue cobalamin deficiency. Br J Haematol. 1998;100:614–5. author reply 617–618.PubMedCrossRef
Metadata
Title
The Importance of Methylmalonic Acid Dosage on the Assessment of Patients with Neurological Manifestations Following Bariatric Surgery
Authors
Camilo Vieira
Camila Cosmo
Rita Lucena
Publication date
01-12-2011
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 12/2011
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-011-0449-3

Other articles of this Issue 12/2011

Obesity Surgery 12/2011 Go to the issue