Skip to main content
Top
Published in: Archives of Osteoporosis 1/2023

01-12-2023 | Osteoporosis | Original Article

Two-country comparison of the prescription of bone protection medication before and early after hip fracture

Authors: Nicole K. Halim, Roger G. Harris, Ian D. Cameron, Jacqueline Close, Ian A. Harris, Jamie Hallen, Sarah Hurring, Nicola Ward, Catherine McDougall, Rebecca J. Mitchell

Published in: Archives of Osteoporosis | Issue 1/2023

Login to get access

Abstract

Summary

Pharmacological management of bone health warrants investigation into factors influencing initiation of bone protection medication (BPM) at discharge after a hip fracture. This sprint audit identified reasons attributed to low BPM treatment levels at hospital discharge which can guide improvement in the prevention of future fractures.

Purpose

To compare patient characteristics and Australian and New Zealand approaches to prescribing bone protection medication (BPM) pre- or post-hip fracture, determine reasons why BPM was not prescribed earlier post-fracture, and assess the generalisability of sprint audit and the Australian and New Zealand Hip Fracture Registry (ANZHFR) patient cohorts.

Methods

A retrospective cohort study of hip fracture patients from the ANZHFR aged ≥ 50 years (2016–2020) and consecutive patients from the 2021 BPM sprint audit. Multivariable logistic regression was used to examine factors associated with not prescribing BPM.

Results

Of 55,618 patients admitted with a hip fracture in the ANZHFR, less than 10% of patients in Australia and New Zealand were taking BPM on admission, increasing to 22.4% in Australia and 27.8% in New Zealand on discharge. Registry patients who were younger (50–69 years), healthy (ASA grade 1), lived in a residential aged care facility, had impaired cognition, delirium identified, or were awaiting a specialist falls assessment were less likely to take BPM. Within the audit, 46.2% of patients in Australia and 39.2% in New Zealand did not have BPM in their discharge prescription. The most common reason for not prescribing BPM in Australia was low level of vitamin D (13.3%), and in New Zealand, renal impairment (14.8%). Sprint and registry patient characteristics were comparable in terms of patient age, sex, usual place of residence, and ASA grade.

Conclusions

BPM prescription early after hip fracture is low. Opportunities exist to increase the rate of prescription of medications known to prevent future fractures in this high-risk population.
Appendix
Available only for authorised users
Literature
1.
go back to reference van Oostwaard M (2018) Osteoporosis and the nature of fragility fracture: an overview. In: Hertz K, Santy-Tomlinson J (eds) Fragility fracture nursing: holistic care and management of the orthogeriatric patient. Springer, Cham (CH), pp 1–13 van Oostwaard M (2018) Osteoporosis and the nature of fragility fracture: an overview. In: Hertz K, Santy-Tomlinson J (eds) Fragility fracture nursing: holistic care and management of the orthogeriatric patient. Springer, Cham (CH), pp 1–13
3.
go back to reference Ballane G, Cauley JA, Luckey MM, Fuleihan GE-H (2014) Secular trends in hip fractures worldwide: opposing trends east versus west. J Bone Miner Res 29:1745–1755CrossRefPubMed Ballane G, Cauley JA, Luckey MM, Fuleihan GE-H (2014) Secular trends in hip fractures worldwide: opposing trends east versus west. J Bone Miner Res 29:1745–1755CrossRefPubMed
4.
go back to reference Kanis JA, Odén A, McCloskey EV, Johansson H, Wahl DA, Cooper C, on behalf of the IOFWGoE, Quality of L (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int 23:2239–2256CrossRefPubMedPubMedCentral Kanis JA, Odén A, McCloskey EV, Johansson H, Wahl DA, Cooper C, on behalf of the IOFWGoE, Quality of L (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int 23:2239–2256CrossRefPubMedPubMedCentral
5.
go back to reference Li G, Thabane L, Papaioannou A, Ioannidis G, Levine MAH, Adachi JD (2017) An overview of osteoporosis and frailty in the elderly. BMC Musculoskelet Disord 18:46CrossRefPubMedPubMedCentral Li G, Thabane L, Papaioannou A, Ioannidis G, Levine MAH, Adachi JD (2017) An overview of osteoporosis and frailty in the elderly. BMC Musculoskelet Disord 18:46CrossRefPubMedPubMedCentral
7.
go back to reference Dyer SM, Crotty M, Fairhall N, Magaziner J, Beaupre LA, Cameron ID, Sherrington C, for the Fragility Fracture Network Rehabilitation Research Special Interest G (2016) A critical review of the long-term disability outcomes following hip fracture. BMC Geriatrics 16:158CrossRefPubMedPubMedCentral Dyer SM, Crotty M, Fairhall N, Magaziner J, Beaupre LA, Cameron ID, Sherrington C, for the Fragility Fracture Network Rehabilitation Research Special Interest G (2016) A critical review of the long-term disability outcomes following hip fracture. BMC Geriatrics 16:158CrossRefPubMedPubMedCentral
8.
go back to reference Curtis EM, Woolford S, Holmes C, Cooper C, Harvey NC (2020) General and specific considerations as to why osteoporosis-related care is often suboptimal. Curr Osteoporos Rep 18:38–46CrossRefPubMedPubMedCentral Curtis EM, Woolford S, Holmes C, Cooper C, Harvey NC (2020) General and specific considerations as to why osteoporosis-related care is often suboptimal. Curr Osteoporos Rep 18:38–46CrossRefPubMedPubMedCentral
9.
go back to reference Sözen T, Özışık L, Başaran N (2017) An overview and management of osteoporosis. Eur J Rheumatol 4:46–56CrossRefPubMed Sözen T, Özışık L, Başaran N (2017) An overview and management of osteoporosis. Eur J Rheumatol 4:46–56CrossRefPubMed
10.
go back to reference Ross BJ, Lee OC, Harris MB, Dowd TC, Savoie FH 3rd, Sherman WF (2021) Rates of osteoporosis management and secondary preventative treatment after primary fragility fractures. JB JS Open Access 6(e20):00142 Ross BJ, Lee OC, Harris MB, Dowd TC, Savoie FH 3rd, Sherman WF (2021) Rates of osteoporosis management and secondary preventative treatment after primary fragility fractures. JB JS Open Access 6(e20):00142
11.
go back to reference Curtis EM, Cooper C, Harvey NC (2021) The Osteoporosis Treatment Gap. In: Dennison E (ed) Osteoporosis treatment: a clinical overview. Springer International Publishing, Cham, pp 97–114CrossRef Curtis EM, Cooper C, Harvey NC (2021) The Osteoporosis Treatment Gap. In: Dennison E (ed) Osteoporosis treatment: a clinical overview. Springer International Publishing, Cham, pp 97–114CrossRef
12.
go back to reference Haugan K, Halsteinli V, Døhl Ø, Basso T, Johnsen LG, Foss OA (2021) Health care services and costs after hip fracture, comparing conventional versus standardised care: a retrospective study with 12-month follow-up. Injury 52:3434–3439CrossRefPubMed Haugan K, Halsteinli V, Døhl Ø, Basso T, Johnsen LG, Foss OA (2021) Health care services and costs after hip fracture, comparing conventional versus standardised care: a retrospective study with 12-month follow-up. Injury 52:3434–3439CrossRefPubMed
15.
go back to reference Currie C (2018) Hip fracture audit: creating a ‘critical mass of expertise and enthusiasm for hip fracture care’? Injury 49:1418–1423CrossRefPubMed Currie C (2018) Hip fracture audit: creating a ‘critical mass of expertise and enthusiasm for hip fracture care’? Injury 49:1418–1423CrossRefPubMed
16.
go back to reference Johansen A, Golding D, Brent L, Close J, Gjertsen J-E, Holt G, Hommel A, Pedersen AB, Röck ND, Thorngren K-G (2017) Using national hip fracture registries and audit databases to develop an international perspective. Injury 48:2174–2179CrossRefPubMed Johansen A, Golding D, Brent L, Close J, Gjertsen J-E, Holt G, Hommel A, Pedersen AB, Röck ND, Thorngren K-G (2017) Using national hip fracture registries and audit databases to develop an international perspective. Injury 48:2174–2179CrossRefPubMed
19.
go back to reference Gunathilake R, Epstein E, McNeill S, Walsh B (2016) Factors associated with receiving anti-osteoporosis treatment among older persons with minimal trauma hip fracture presenting to an acute orthogeriatric service. Injury 47:2149–2154CrossRefPubMed Gunathilake R, Epstein E, McNeill S, Walsh B (2016) Factors associated with receiving anti-osteoporosis treatment among older persons with minimal trauma hip fracture presenting to an acute orthogeriatric service. Injury 47:2149–2154CrossRefPubMed
20.
go back to reference Walsh ME, Nerdrum M, Fahey T, Moriarty F (2021) Factors associated with initiation of bone-health medication among older adults in primary care in Ireland. Age Ageing 50:1649–1656CrossRefPubMedPubMedCentral Walsh ME, Nerdrum M, Fahey T, Moriarty F (2021) Factors associated with initiation of bone-health medication among older adults in primary care in Ireland. Age Ageing 50:1649–1656CrossRefPubMedPubMedCentral
21.
go back to reference Klop C, Gibson-Smith D, Elders PJM, Welsing PMJ, Leufkens HGM, Harvey NC, Bijlsma JWJ, van Staa TP, de Vries F (2015) Anti-osteoporosis drug prescribing after hip fracture in the UK: 2000–2010. Osteoporos Int 26:1919–1928CrossRefPubMedPubMedCentral Klop C, Gibson-Smith D, Elders PJM, Welsing PMJ, Leufkens HGM, Harvey NC, Bijlsma JWJ, van Staa TP, de Vries F (2015) Anti-osteoporosis drug prescribing after hip fracture in the UK: 2000–2010. Osteoporos Int 26:1919–1928CrossRefPubMedPubMedCentral
22.
go back to reference Barton DW, Piple AS, Smith CT, Moskal SA, Carmouche JJ (2021) The clinical impact of fracture liaison services: a systematic review. Geriatr Orthop Surg Rehabil 12:2151459320979978 Barton DW, Piple AS, Smith CT, Moskal SA, Carmouche JJ (2021) The clinical impact of fracture liaison services: a systematic review. Geriatr Orthop Surg Rehabil 12:2151459320979978
23.
go back to reference Drew S, Judge A, Cooper C, Javaid MK, Farmer A, Gooberman-Hill R (2016) Secondary prevention of fractures after hip fracture: a qualitative study of effective service delivery. Osteoporos Int 27:1719–1727CrossRefPubMedPubMedCentral Drew S, Judge A, Cooper C, Javaid MK, Farmer A, Gooberman-Hill R (2016) Secondary prevention of fractures after hip fracture: a qualitative study of effective service delivery. Osteoporos Int 27:1719–1727CrossRefPubMedPubMedCentral
24.
go back to reference Morri M, Forni C, Guberti M, Chiari P, Pecorari A, Orlandi AM, Gazineo D, Bozzo M, Ambrosi E (2022) Post-hospital care pathway for individuals with hip fracture: what is the optimal setting and rehabilitation intensity? An observational study. Disabil Rehabil 44:4241–4248CrossRefPubMed Morri M, Forni C, Guberti M, Chiari P, Pecorari A, Orlandi AM, Gazineo D, Bozzo M, Ambrosi E (2022) Post-hospital care pathway for individuals with hip fracture: what is the optimal setting and rehabilitation intensity? An observational study. Disabil Rehabil 44:4241–4248CrossRefPubMed
25.
go back to reference Conley RB, Adib G, Adler RA et al (2019) Secondary fracture prevention: consensus clinical recommendations from a multistakeholder coalition. J Bone Miner Res 35:36–52CrossRefPubMed Conley RB, Adib G, Adler RA et al (2019) Secondary fracture prevention: consensus clinical recommendations from a multistakeholder coalition. J Bone Miner Res 35:36–52CrossRefPubMed
26.
go back to reference Paskins Z, Babatunde O, Sturrock A et al (2022) Supporting patients to get the best from their osteoporosis treatment: a rapid realist review of what works, for whom, and in what circumstance. Osteoporos Int 33:2245–2257CrossRefPubMedPubMedCentral Paskins Z, Babatunde O, Sturrock A et al (2022) Supporting patients to get the best from their osteoporosis treatment: a rapid realist review of what works, for whom, and in what circumstance. Osteoporos Int 33:2245–2257CrossRefPubMedPubMedCentral
27.
go back to reference Kristensen PK, Ehrenstein V, Shetty N, Pedersen AB (2019) Use of anti-osteoporosis medication dispensing by patients with hip fracture: could we do better? Osteoporosis Int 30:1817–1825CrossRef Kristensen PK, Ehrenstein V, Shetty N, Pedersen AB (2019) Use of anti-osteoporosis medication dispensing by patients with hip fracture: could we do better? Osteoporosis Int 30:1817–1825CrossRef
28.
go back to reference Naik-Panvelkar P, Norman S, Elgebaly Z, Elliott J, Pollack A, Thistlethwaite J, Weston C, Seibel MJ (2020) Osteoporosis management in Australian general practice: an analysis of current osteoporosis treatment patterns and gaps in practice. BMC Fam Pract 21:32CrossRefPubMedPubMedCentral Naik-Panvelkar P, Norman S, Elgebaly Z, Elliott J, Pollack A, Thistlethwaite J, Weston C, Seibel MJ (2020) Osteoporosis management in Australian general practice: an analysis of current osteoporosis treatment patterns and gaps in practice. BMC Fam Pract 21:32CrossRefPubMedPubMedCentral
29.
go back to reference Duque G, Lord SR, Mak J, Ganda K, Close JJT, Ebeling P, Papaioannou A, Inderjeeth CA (2016) Treatment of osteoporosis in Australian residential aged care facilities: update on consensus recommendations for fracture prevention. J Am Med Dir Assoc 17:852–859CrossRefPubMedPubMedCentral Duque G, Lord SR, Mak J, Ganda K, Close JJT, Ebeling P, Papaioannou A, Inderjeeth CA (2016) Treatment of osteoporosis in Australian residential aged care facilities: update on consensus recommendations for fracture prevention. J Am Med Dir Assoc 17:852–859CrossRefPubMedPubMedCentral
30.
go back to reference Lind KE, Jorgensen ML, Gray LC, Georgiou A, Westbrook JI (2019) Anti-osteoporosis medication use in a high fracture-risk population: contemporary trends in Australian residential aged care facilities. Health Serv Insights 12:1178632919852111 Lind KE, Jorgensen ML, Gray LC, Georgiou A, Westbrook JI (2019) Anti-osteoporosis medication use in a high fracture-risk population: contemporary trends in Australian residential aged care facilities. Health Serv Insights 12:1178632919852111
31.
go back to reference Duque G, Iuliano S, Close JCT et al (2022) Prevention of osteoporotic fractures in residential aged care: updated consensus recommendations. J Am Med Dir Assoc 23:756–763CrossRefPubMed Duque G, Iuliano S, Close JCT et al (2022) Prevention of osteoporotic fractures in residential aged care: updated consensus recommendations. J Am Med Dir Assoc 23:756–763CrossRefPubMed
32.
go back to reference Liu E, Killington M, Cameron ID, Li R, Kurrle S, Crotty M (2021) Life expectancy of older people living in aged care facilities after a hip fracture. Sci Rep 11:20266CrossRefPubMedPubMedCentral Liu E, Killington M, Cameron ID, Li R, Kurrle S, Crotty M (2021) Life expectancy of older people living in aged care facilities after a hip fracture. Sci Rep 11:20266CrossRefPubMedPubMedCentral
33.
go back to reference Cameron ID, Dyer SM, Panagoda CE, Murray GR, Hill KD, Cumming RG, Kerse N (2018) Interventions for preventing falls in older people in care facilities and hospitals. Cochrane Database Syst Rev 9:Cd005465PubMed Cameron ID, Dyer SM, Panagoda CE, Murray GR, Hill KD, Cumming RG, Kerse N (2018) Interventions for preventing falls in older people in care facilities and hospitals. Cochrane Database Syst Rev 9:Cd005465PubMed
35.
go back to reference Li N, Cornelissen D, Silverman S et al (2021) An updated systematic review of cost-effectiveness analyses of drugs for osteoporosis. Pharmacoeconomics 39:181–209CrossRefPubMed Li N, Cornelissen D, Silverman S et al (2021) An updated systematic review of cost-effectiveness analyses of drugs for osteoporosis. Pharmacoeconomics 39:181–209CrossRefPubMed
37.
go back to reference Lacey LF, Armstrong DJ, Royle E, Magee P, Pourshahidi LK, Ray S, Strain JJ, McSorley E (2022) Cost-effectiveness of vitamin D3 supplementation in older adults with vitamin D deficiency in Ireland. BMJ Nutrition, Prevention & Health 5:e000382 Lacey LF, Armstrong DJ, Royle E, Magee P, Pourshahidi LK, Ray S, Strain JJ, McSorley E (2022) Cost-effectiveness of vitamin D3 supplementation in older adults with vitamin D deficiency in Ireland. BMJ Nutrition, Prevention & Health 5:e000382
38.
go back to reference Fatoye F, Smith P, Gebrye T, Yeowell G (2019) Real-world persistence and adherence with oral bisphosphonates for osteoporosis: a systematic review. BMJ Open 9:e027049–e027049CrossRefPubMedPubMedCentral Fatoye F, Smith P, Gebrye T, Yeowell G (2019) Real-world persistence and adherence with oral bisphosphonates for osteoporosis: a systematic review. BMJ Open 9:e027049–e027049CrossRefPubMedPubMedCentral
40.
go back to reference Royal College of Physicians (2019) National Hip Fracture Database annual report 2019. Royal College of Physicians, London Royal College of Physicians (2019) National Hip Fracture Database annual report 2019. Royal College of Physicians, London
41.
go back to reference Reid IR, Billington EO (2022) Drug therapy for osteoporosis in older adults. Lancet 399:1080–1092CrossRefPubMed Reid IR, Billington EO (2022) Drug therapy for osteoporosis in older adults. Lancet 399:1080–1092CrossRefPubMed
42.
go back to reference Heaney RP, Armas LA, Shary JR, Bell NH, Binkley N, Hollis BW (2008) 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions. Am J Clin Nutr 87:1738–1742CrossRefPubMed Heaney RP, Armas LA, Shary JR, Bell NH, Binkley N, Hollis BW (2008) 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions. Am J Clin Nutr 87:1738–1742CrossRefPubMed
43.
go back to reference Bacon CJ, Gamble GD, Horne AM, Scott MA, Reid IR (2009) High-dose oral vitamin D3 supplementation in the elderly. Osteoporos Int 20:1407–1415CrossRefPubMed Bacon CJ, Gamble GD, Horne AM, Scott MA, Reid IR (2009) High-dose oral vitamin D3 supplementation in the elderly. Osteoporos Int 20:1407–1415CrossRefPubMed
45.
go back to reference Australian and New Zealand Hip Fracture Registry (2020) ANZHFR Annual Report of Hip Fracture Care 2020. Australian and New Zealand Hip Fracture Registry, Sydney Australian and New Zealand Hip Fracture Registry (2020) ANZHFR Annual Report of Hip Fracture Care 2020. Australian and New Zealand Hip Fracture Registry, Sydney
46.
go back to reference Yeam CT, Chia S, Tan HCC, Kwan YH, Fong W, Seng JJB (2018) A systematic review of factors affecting medication adherence among patients with osteoporosis. Osteoporos Int 29:2623–2637CrossRefPubMed Yeam CT, Chia S, Tan HCC, Kwan YH, Fong W, Seng JJB (2018) A systematic review of factors affecting medication adherence among patients with osteoporosis. Osteoporos Int 29:2623–2637CrossRefPubMed
Metadata
Title
Two-country comparison of the prescription of bone protection medication before and early after hip fracture
Authors
Nicole K. Halim
Roger G. Harris
Ian D. Cameron
Jacqueline Close
Ian A. Harris
Jamie Hallen
Sarah Hurring
Nicola Ward
Catherine McDougall
Rebecca J. Mitchell
Publication date
01-12-2023
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2023
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-022-01197-4

Other articles of this Issue 1/2023

Archives of Osteoporosis 1/2023 Go to the issue