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Published in: Archives of Osteoporosis 1/2019

Open Access 01-12-2019 | Original Article

Age-specific 1-year mortality rates after hip fracture based on the populations in mainland China between the years 2000 and 2018: a systematic analysis

Authors: Zhiyong Cui, Hui Feng, Xiangyu Meng, Siying Zhuang, Zhaorui Liu, Kaifeng Ye, Chuan Sun, Yong Xing, Fang Zhou, Yun Tian

Published in: Archives of Osteoporosis | Issue 1/2019

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Abstract

Summary

We used statistical approaches to calculate 1-year mortality rates and reveal the relationship between age and the 1-year mortality rate after hip fracture based on data from mainland China between the years 2000 and 2018.

Introduction

Data on the 1-year mortality rates after hip fracture in mainland China remain limited and localized. We aimed to analyze the 1-year mortality rates and reveal the variations in 1-year mortality by age after hip fracture based on data from mainland China.

Methods

We searched PubMed, EMBASE, Cochrane Library, CNKI, Wanfang, and CBM-SinoMed for all relevant articles in English or Chinese to estimate the 1-year mortality rates after hip fracture in mainland China. A random-effects meta-analysis model was fitted to pool the overall 1-year mortality rates. A multilevel mixed-effects meta-regression model was developed. Based on the final model, the age-specific 1-year mortality rates after hip fracture in mainland China were generated.

Results

The pooled estimate of the 1-year mortality rate was 13.96% after hip fracture (95% CI 12.26 to 15.86%), 17.47% after femoral intertrochanteric fracture (95% CI 14.29 to 21.20%), and 9.83% after femoral neck fracture (95% CI 6.96 to 13.72%) between the years 2000 and 2018. We found that the 1-year mortality rates ranged from 2.65% (95% CI 1.76 to 3.99%) in those aged 50~54 years to 28.91% (95% CI 24.23 to 34.30%) in those aged 95~99 years after hip fracture; ranged from 1.73% (95% CI 0.58 to 4.99%) in those aged 50~54 years to 50.11% (95% CI 46.03% to 53.97%) in those aged 95~99 years after femoral intertrochanteric fracture; and ranged from 1.66% (95% CI 1.31 to 2.11%) in those aged 60~64 years to 37.71% (95% CI 27.92 to 48.63%) in those aged 95~99 years after femoral neck fracture.

Conclusion

In this systematic review and meta-analysis, we calculated the 1-year mortality rate after hip fracture in mainland China and found that this rate was lower than that in most countries. We also estimated the age-specific mortality rates for different age groups after hip fracture. These findings will be beneficial for the prevention and treatment of hip fracture in mainland China.
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Literature
1.
go back to reference Tosteson AN, Gottlieb DJ, Radley DC, Fisher ES, Melton LJ 3rd (2007) Excess mortality following hip fracture: the role of underlying health status. Osteoporos Int 18:1463–1472PubMedPubMedCentralCrossRef Tosteson AN, Gottlieb DJ, Radley DC, Fisher ES, Melton LJ 3rd (2007) Excess mortality following hip fracture: the role of underlying health status. Osteoporos Int 18:1463–1472PubMedPubMedCentralCrossRef
2.
go back to reference Banks E, Reeves GK, Beral V, Balkwill A, Liu B, Roddam A, for the Million Women Study Collaborators (2009) Hip fracture incidence in relation to age, menopausal status, and age at menopause: prospective analysis. PLoS Med 6:e1000181PubMedPubMedCentralCrossRef Banks E, Reeves GK, Beral V, Balkwill A, Liu B, Roddam A, for the Million Women Study Collaborators (2009) Hip fracture incidence in relation to age, menopausal status, and age at menopause: prospective analysis. PLoS Med 6:e1000181PubMedPubMedCentralCrossRef
3.
go back to reference Kanis JA, Oden A, McCloskey EV et al (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int 23:2239–2256PubMedPubMedCentralCrossRef Kanis JA, Oden A, McCloskey EV et al (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int 23:2239–2256PubMedPubMedCentralCrossRef
4.
go back to reference Karres J, Kieviet N, Eerenberg JP, Vrouenraets BC (2018) Predicting early mortality after hip fracture surgery: the hip fracture estimator of mortality Amsterdam. J Orthop Trauma 32:27–33PubMedCrossRef Karres J, Kieviet N, Eerenberg JP, Vrouenraets BC (2018) Predicting early mortality after hip fracture surgery: the hip fracture estimator of mortality Amsterdam. J Orthop Trauma 32:27–33PubMedCrossRef
5.
go back to reference Liu Y, Wang Z, Xiao W (2018) Risk factors for mortality in elderly patients with hip fractures: a meta-analysis of 18 studies. Aging Clin Exp Res 30:323–330PubMedCrossRef Liu Y, Wang Z, Xiao W (2018) Risk factors for mortality in elderly patients with hip fractures: a meta-analysis of 18 studies. Aging Clin Exp Res 30:323–330PubMedCrossRef
6.
go back to reference Katsoulis M, Benetou V, Karapetyan T, Feskanich D, Grodstein F, Pettersson-Kymmer U, Eriksson S, Wilsgaard T, Jørgensen L, Ahmed LA, Schöttker B, Brenner H, Bellavia A, Wolk A, Kubinova R, Stegeman B, Bobak M, Boffetta P, Trichopoulou A (2017) Excess mortality after hip fracture in elderly persons from Europe and the USA: the CHANCES project. J Intern Med 281:300–310PubMedCrossRef Katsoulis M, Benetou V, Karapetyan T, Feskanich D, Grodstein F, Pettersson-Kymmer U, Eriksson S, Wilsgaard T, Jørgensen L, Ahmed LA, Schöttker B, Brenner H, Bellavia A, Wolk A, Kubinova R, Stegeman B, Bobak M, Boffetta P, Trichopoulou A (2017) Excess mortality after hip fracture in elderly persons from Europe and the USA: the CHANCES project. J Intern Med 281:300–310PubMedCrossRef
7.
go back to reference Richmond J, Aharonoff GB, Zucherman JD, Koval KJ (2003) Mortality risk after hip fracture. J Orthop Trauma 17:S2–S5PubMedCrossRef Richmond J, Aharonoff GB, Zucherman JD, Koval KJ (2003) Mortality risk after hip fracture. J Orthop Trauma 17:S2–S5PubMedCrossRef
8.
go back to reference Melton LJ 3rd (2003) Adverse outcomes of osteoporotic fractures in the general population. J Bone Miner Res 18:1139–1141PubMedCrossRef Melton LJ 3rd (2003) Adverse outcomes of osteoporotic fractures in the general population. J Bone Miner Res 18:1139–1141PubMedCrossRef
9.
go back to reference Qasim M, Andrews RM (2013) Despite overall improvement in surgical outcomes since 2000, income-related disparities persist. Health Aff (Millwood) 32:1773–1780CrossRef Qasim M, Andrews RM (2013) Despite overall improvement in surgical outcomes since 2000, income-related disparities persist. Health Aff (Millwood) 32:1773–1780CrossRef
10.
go back to reference Stroup DF, Berlin JA, Morton SC et al (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA 283:2008–2012PubMedCrossRef Stroup DF, Berlin JA, Morton SC et al (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA 283:2008–2012PubMedCrossRef
11.
go back to reference Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25:603–605PubMedCrossRef Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25:603–605PubMedCrossRef
12.
go back to reference Song P, Wang J, Bucan K, Theodoratou E, Rudan I, Chan KY (2017) National and subnational prevalence and burden of glaucoma in China: a systematic analysis. J Global Health 7:020705CrossRef Song P, Wang J, Bucan K, Theodoratou E, Rudan I, Chan KY (2017) National and subnational prevalence and burden of glaucoma in China: a systematic analysis. J Global Health 7:020705CrossRef
13.
go back to reference Fowkes FG, Rudan D, Rudan I et al (2013) Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis. Lancet 382:1329–1340PubMedCrossRef Fowkes FG, Rudan D, Rudan I et al (2013) Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis. Lancet 382:1329–1340PubMedCrossRef
14.
go back to reference Haentjens P, Magaziner J, Colón-Emeric CS, Vanderschueren D, Milisen K, Velkeniers B, Boonen S (2010) Meta-analysis: excess mortality after hip fracture among older women and men. Ann Intern Med 152:380–390PubMedPubMedCentralCrossRef Haentjens P, Magaziner J, Colón-Emeric CS, Vanderschueren D, Milisen K, Velkeniers B, Boonen S (2010) Meta-analysis: excess mortality after hip fracture among older women and men. Ann Intern Med 152:380–390PubMedPubMedCentralCrossRef
15.
go back to reference Haleem S, Lutchman L, Mayahi R, Grice JE, Parker MJ (2008) Mortality following hip fracture: trends and geographical variations over the last 40 years. Injury 39:1157–1163PubMedCrossRef Haleem S, Lutchman L, Mayahi R, Grice JE, Parker MJ (2008) Mortality following hip fracture: trends and geographical variations over the last 40 years. Injury 39:1157–1163PubMedCrossRef
16.
go back to reference Berry SD, Samelson EJ, Bordes M, Broe K, Kiel DP (2009) Survival of aged nursing home residents with hip fracture. J Gerontol A Biol Sci Med Sci 64:771–777PubMedCrossRef Berry SD, Samelson EJ, Bordes M, Broe K, Kiel DP (2009) Survival of aged nursing home residents with hip fracture. J Gerontol A Biol Sci Med Sci 64:771–777PubMedCrossRef
17.
go back to reference Abrahamsen B, van Staa T, Ariely R, Olson M, Cooper C (2009) Excess mortality following hip fracture: a systematic epidemiological review. Osteoporos Int 20:1633–1650CrossRefPubMed Abrahamsen B, van Staa T, Ariely R, Olson M, Cooper C (2009) Excess mortality following hip fracture: a systematic epidemiological review. Osteoporos Int 20:1633–1650CrossRefPubMed
18.
go back to reference Hu F, Jiang C, Shen J, Tang P, Wang Y (2012) Preoperative predictors for mortality following hip fracture surgery: a systematic review and meta-analysis. Injury 43:676–685CrossRefPubMed Hu F, Jiang C, Shen J, Tang P, Wang Y (2012) Preoperative predictors for mortality following hip fracture surgery: a systematic review and meta-analysis. Injury 43:676–685CrossRefPubMed
19.
go back to reference Beaupre LA, Jones CA, Johnston DW, Wilson DM, Majumdar SR (2012) Recovery of function following a hip fracture in geriatric ambulatory persons living in nursing homes: prospective cohort study. J Am Geriatr Soc 60:1268–1273PubMedCrossRef Beaupre LA, Jones CA, Johnston DW, Wilson DM, Majumdar SR (2012) Recovery of function following a hip fracture in geriatric ambulatory persons living in nursing homes: prospective cohort study. J Am Geriatr Soc 60:1268–1273PubMedCrossRef
20.
21.
go back to reference Man LP, Ho AW, Wong SH (2016) Excess mortality for operated geriatric hip fracture in Hong Kong. Hong Kong Med J 22:6–10PubMed Man LP, Ho AW, Wong SH (2016) Excess mortality for operated geriatric hip fracture in Hong Kong. Hong Kong Med J 22:6–10PubMed
22.
go back to reference Wang CB, Lin CF, Liang WM et al (2013) Excess mortality after hip fracture among the elderly in Taiwan: a nationwide population-based cohort study. Bone 56:147–153PubMedCrossRef Wang CB, Lin CF, Liang WM et al (2013) Excess mortality after hip fracture among the elderly in Taiwan: a nationwide population-based cohort study. Bone 56:147–153PubMedCrossRef
23.
go back to reference Li S, Sun T, Liu Z (2016) Excess mortality of 1 year in elderly hip fracture patients compared with the general population in Beijing, China. Arch Osteoporos 11:35CrossRefPubMed Li S, Sun T, Liu Z (2016) Excess mortality of 1 year in elderly hip fracture patients compared with the general population in Beijing, China. Arch Osteoporos 11:35CrossRefPubMed
25.
go back to reference Mangram A, Moeser P, Corneille MG, Prokuski LJ, Zhou N, Sohn J, Chaliki S, Oguntodu OF, Dzandu JK (2014) Geriatric trauma hip fractures: is there a difference in outcomes based on fracture patterns? World J Emerg Surg 9:59PubMedPubMedCentralCrossRef Mangram A, Moeser P, Corneille MG, Prokuski LJ, Zhou N, Sohn J, Chaliki S, Oguntodu OF, Dzandu JK (2014) Geriatric trauma hip fractures: is there a difference in outcomes based on fracture patterns? World J Emerg Surg 9:59PubMedPubMedCentralCrossRef
26.
go back to reference Haentjens P, Autier P, Barette M, Venken K, Vanderschueren D, Boonen S, Hip Fracture Study Group (2007) Survival and functional outcome according to hip fracture type: a one-year prospective cohort study in elderly women with an intertrochanteric or femoral neck fracture. Bone 41:958–964PubMedCrossRef Haentjens P, Autier P, Barette M, Venken K, Vanderschueren D, Boonen S, Hip Fracture Study Group (2007) Survival and functional outcome according to hip fracture type: a one-year prospective cohort study in elderly women with an intertrochanteric or femoral neck fracture. Bone 41:958–964PubMedCrossRef
27.
go back to reference Karagiannis A, Papakitsou E, Dretakis K, Galanos A, Megas P, Lambiris E, Lyritis GP (2006) Mortality rates of patients with a hip fracture in a southwestern district of Greece: ten-year follow-up with reference to the type of fracture. Calcif Tissue Int 78:72–77PubMedCrossRef Karagiannis A, Papakitsou E, Dretakis K, Galanos A, Megas P, Lambiris E, Lyritis GP (2006) Mortality rates of patients with a hip fracture in a southwestern district of Greece: ten-year follow-up with reference to the type of fracture. Calcif Tissue Int 78:72–77PubMedCrossRef
28.
go back to reference Chau PH, Wong M, Lee A, Ling M, Woo J (2013) Trends in hip fracture incidence and mortality in Chinese population from Hong Kong 2001-09. Age Ageing 42:229–233CrossRefPubMed Chau PH, Wong M, Lee A, Ling M, Woo J (2013) Trends in hip fracture incidence and mortality in Chinese population from Hong Kong 2001-09. Age Ageing 42:229–233CrossRefPubMed
29.
go back to reference Barrett-Connor E, Siris ES, Wehren LE, Miller PD, Abbott TA, Berger ML, Santora AC, Sherwood LM (2005) Osteoporosis and fracture risk in women of different ethnic groups. J Bone Miner Res 20:185–194PubMedCrossRef Barrett-Connor E, Siris ES, Wehren LE, Miller PD, Abbott TA, Berger ML, Santora AC, Sherwood LM (2005) Osteoporosis and fracture risk in women of different ethnic groups. J Bone Miner Res 20:185–194PubMedCrossRef
30.
go back to reference Finkelstein JS, Lee ML, Sowers M et al (2002) Ethnic variation in bone density in premenopausal and early perimenopausal women: effects of anthropometric and lifestyle factors. J Clin Endocrinol Metab 87:3057–3067PubMedCrossRef Finkelstein JS, Lee ML, Sowers M et al (2002) Ethnic variation in bone density in premenopausal and early perimenopausal women: effects of anthropometric and lifestyle factors. J Clin Endocrinol Metab 87:3057–3067PubMedCrossRef
31.
go back to reference Walker MD, McMahon J, Udesky J, Liu G, Bilezikian JP (2009) Application of high resolution skeletal imaging to measurements of volumetric BMD and skeletal microarchitecture in Chinese-American and white women: explanation of a paradox. J Bone Miner Res 24:1953–1959PubMedPubMedCentralCrossRef Walker MD, McMahon J, Udesky J, Liu G, Bilezikian JP (2009) Application of high resolution skeletal imaging to measurements of volumetric BMD and skeletal microarchitecture in Chinese-American and white women: explanation of a paradox. J Bone Miner Res 24:1953–1959PubMedPubMedCentralCrossRef
32.
33.
go back to reference Penrod JD, Litke A, Hawkes WG, Magaziner J, Doucette JT, Koval KJ, Silberzweig SB, Egol KA, Siu AL (2008) The association of race, gender, and comorbidity with mortality and function after hip fracture. J Gerontol A Biol Sci Med Sci 63:867–872PubMedCrossRef Penrod JD, Litke A, Hawkes WG, Magaziner J, Doucette JT, Koval KJ, Silberzweig SB, Egol KA, Siu AL (2008) The association of race, gender, and comorbidity with mortality and function after hip fracture. J Gerontol A Biol Sci Med Sci 63:867–872PubMedCrossRef
34.
go back to reference Lu-Yao GL, Baron JA, Barrett JA, Fisher ES (1994) Treatment and survival among elderly Americans with hip fractures: a population-based study. Am J Public Health 84:1287–1291PubMedPubMedCentralCrossRef Lu-Yao GL, Baron JA, Barrett JA, Fisher ES (1994) Treatment and survival among elderly Americans with hip fractures: a population-based study. Am J Public Health 84:1287–1291PubMedPubMedCentralCrossRef
35.
go back to reference Jacobsen SJ, Goldberg J, Miles TP, Brody JA, Stiers W, Rimm AA (1992) Race and sex differences in mortality following fracture of the hip. Am J Public Health 82:1147–1150PubMedPubMedCentralCrossRef Jacobsen SJ, Goldberg J, Miles TP, Brody JA, Stiers W, Rimm AA (1992) Race and sex differences in mortality following fracture of the hip. Am J Public Health 82:1147–1150PubMedPubMedCentralCrossRef
36.
go back to reference Pincus D, Ravi B, Wasserstein D, Huang A, Paterson JM, Nathens AB, Kreder HJ, Jenkinson RJ, Wodchis WP (2017) Association between wait time and 30-day mortality in adults undergoing hip fracture surgery. JAMA 318:1994–2003PubMedPubMedCentralCrossRef Pincus D, Ravi B, Wasserstein D, Huang A, Paterson JM, Nathens AB, Kreder HJ, Jenkinson RJ, Wodchis WP (2017) Association between wait time and 30-day mortality in adults undergoing hip fracture surgery. JAMA 318:1994–2003PubMedPubMedCentralCrossRef
37.
go back to reference Jacobs H, Zeeb H, Hoffmann F (2018) Incidence rates of and mortality after hip fracture among German nursing home residents. Int J Environ Res Public Health 15:E289PubMedCrossRef Jacobs H, Zeeb H, Hoffmann F (2018) Incidence rates of and mortality after hip fracture among German nursing home residents. Int J Environ Res Public Health 15:E289PubMedCrossRef
38.
go back to reference Harris IA, Yong S, McEvoy L, Thorn L (2010) A prospective study of the effect of nursing home residency on mortality following hip fracture. ANZ J Surg 80:447–450PubMedCrossRef Harris IA, Yong S, McEvoy L, Thorn L (2010) A prospective study of the effect of nursing home residency on mortality following hip fracture. ANZ J Surg 80:447–450PubMedCrossRef
39.
go back to reference Zeng Y, Feng Q, Hesketh T, Christensen K, Vaupel JW (2017) Survival, disabilities in activities of daily living, and physical and cognitive functioning among the oldest-old in China: a cohort study. Lancet 389:1619–1629PubMedPubMedCentralCrossRef Zeng Y, Feng Q, Hesketh T, Christensen K, Vaupel JW (2017) Survival, disabilities in activities of daily living, and physical and cognitive functioning among the oldest-old in China: a cohort study. Lancet 389:1619–1629PubMedPubMedCentralCrossRef
41.
go back to reference Quah C, Boulton C, Moran C (2011) The influence of socioeconomic status on the incidence, outcome and mortality of fractures of the hip. J Bone Joint Surg Br 93:801–805PubMedCrossRef Quah C, Boulton C, Moran C (2011) The influence of socioeconomic status on the incidence, outcome and mortality of fractures of the hip. J Bone Joint Surg Br 93:801–805PubMedCrossRef
42.
go back to reference Roberts SE, Goldacre MJ (2003) Time trends and demography of mortality after fractured neck of femur in an English population, 1968-98: database study. BMJ 327:771–775PubMedPubMedCentralCrossRef Roberts SE, Goldacre MJ (2003) Time trends and demography of mortality after fractured neck of femur in an English population, 1968-98: database study. BMJ 327:771–775PubMedPubMedCentralCrossRef
43.
go back to reference Bentler SE, Liu L, Obrizan M, Cook EA, Wright KB, Geweke JF, Chrischilles EA, Pavlik CE, Wallace RB, Ohsfeldt RL, Jones MP, Rosenthal GE, Wolinsky FD (2009) The aftermath of hip fracture: discharge placement, functional status change, and mortality. Am J Epidemiol 170:1290–1299PubMedPubMedCentralCrossRef Bentler SE, Liu L, Obrizan M, Cook EA, Wright KB, Geweke JF, Chrischilles EA, Pavlik CE, Wallace RB, Ohsfeldt RL, Jones MP, Rosenthal GE, Wolinsky FD (2009) The aftermath of hip fracture: discharge placement, functional status change, and mortality. Am J Epidemiol 170:1290–1299PubMedPubMedCentralCrossRef
44.
go back to reference Roche JJ, Wenn RT, Sahota O, Moran CG (2005) Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study. BMJ 331:1374PubMedPubMedCentralCrossRef Roche JJ, Wenn RT, Sahota O, Moran CG (2005) Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study. BMJ 331:1374PubMedPubMedCentralCrossRef
45.
go back to reference Neuman MD, Silber JH, Magaziner JS, Passarella MA, Mehta S, Werner RM (2014) Survival and functional outcomes after hip fracture among nursing home residents. JAMA Intern Med 174:1273–1280PubMedPubMedCentralCrossRef Neuman MD, Silber JH, Magaziner JS, Passarella MA, Mehta S, Werner RM (2014) Survival and functional outcomes after hip fracture among nursing home residents. JAMA Intern Med 174:1273–1280PubMedPubMedCentralCrossRef
Metadata
Title
Age-specific 1-year mortality rates after hip fracture based on the populations in mainland China between the years 2000 and 2018: a systematic analysis
Authors
Zhiyong Cui
Hui Feng
Xiangyu Meng
Siying Zhuang
Zhaorui Liu
Kaifeng Ye
Chuan Sun
Yong Xing
Fang Zhou
Yun Tian
Publication date
01-12-2019
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2019
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-019-0604-3

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