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Archives of Osteoporosis

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01-12-2016 | Original Article

A new implementation of digital X-ray radiogrammetry and reference curves of four indices of cortical bone for healthy European adults

Authors: Hans Henrik Thodberg, Joachim Böttcher, Jens Lomholt, Sven Kreiborg, Gunter Wolf, Alexander Pfeil

Published in: Archives of Osteoporosis | Issue 1/2016

Abstract

Summary

Digital X-ray radiogrammetry performs measurements on a hand radiograph in digital form. We present an improved implementation of the method and provide reference curves for four indices for the amount of bone. We collected 1662 hand radiographs of healthy subjects of age 9–100 years.

Purpose

The digital X-ray radiogrammetry (DXR) method has been shown to be efficient for diagnosis of osteoporosis and for assessment of progression of rheumatoid arthritis. The aim of this work is to present a new DXR implementation and reference curves of four indices of cortical bone and to compare their relative SDs in healthy subjects at fixed age and gender.

Materials and methods

A total of 1662 hand radiographs of healthy subjects of age 9–100 years were collected in Jena in 2001–2005. We also used a longitudinal study of 116 Danish children born in 1952 with on average 11 images taken over the age range 7 to 40 years.

The new DXR method reconstructs the whole metacarpal contour so that the metacarpal lengths can be measured and used in two of the indices. The new DXR method automatically validates 97 % of the images and is implemented as a local server for PACS users.

Results

The Danish bone health index (BHI) data are consistent with the Jena data and also with the published BHI reference for healthy children. BHI is found to have smaller relative SD than the other three indices in the Jena cohort over the age range 20–80 years.

Conclusion

The new DXR method is an extension of the existing BoneXpert method for children, which allows patients to be followed from childhood into adulthood with the same method. By making all four indices of cortical bone available within the same medical device, it becomes possible to decide which index has the best relation to fracture risk in future studies.

Available only for authorised users

For males younger than 20 and females younger than 18, the images were analysed with the pediatric version, which validates the analysis in a different way; see [5].

An artist’s impression of this event can be found here http://dodd.cmcvellore.ac.in/hom/36%20-%20Rontgen.html

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Title: A new implementation of digital X-ray radiogrammetry and reference curves of four indices of cortical bone for healthy European adults
Authors: Hans Henrik Thodberg
Joachim Böttcher
Jens Lomholt
Sven Kreiborg
Gunter Wolf
Alexander Pfeil
Publication date: 01-12-2016
Publisher: Springer London
Published in: Archives of Osteoporosis / Issue 1/2016
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-016-0267-2

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A new implementation of digital X-ray radiogrammetry and reference curves of four indices of cortical bone for healthy European adults

Abstract

Summary

Purpose

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Summary

Purpose

Materials and methods

Results

Conclusion

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