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01-07-2020 | Aortic Valve Replacement | Concise Research Report

Chronic Conditions in Advanced Cardiac Disease: A Cluster Analysis of Transcatheter Aortic Valve Replacement (TAVR)-Treated Patients

Authors: Benjamin S. Wessler, MD, MS, Benjamin C. Koethe, MPH, Paul K. J. Han, MD, MA, MPH, Andrew R. Weintraub, MD, James E. Udelson, MD, Cynthia M. Boyd, MD, MPH, David M. Kent, MD, CM, MS

Published in: Journal of General Internal Medicine | Issue 7/2020

Excerpt

Transcatheter aortic valve replacement (TAVR) has revolutionized the care of older adults with symptomatic aortic stenosis, enabling treatment where once there was none.¹ One third of these high-risk patients remain severely symptomatic or die 1 year after treatment and half of all deaths are due to non-cardiac causes.² TAVR patients provide a unique opportunity to study multiple chronic conditions (MCC) for older adults with advanced cardiovascular disease (CVD). Here, we examine patterns of MCC present at the time of treatment and explore associations with short- and long-term patient-centered outcomes. …

Leon MB, Smith CR, Mack M, et al. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med 2010;363(17):1597–1607. https://doi.org/10.1056/NEJMoa1008232 CrossRefPubMed

Xiong T-Y, Liao Y-B, Zhao Z-G, et al. Causes of Death Following Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis. J Am Heart Assoc 2015;4(9):e002096. https://doi.org/10.1161/JAHA.115.002096 CrossRefPubMedPubMedCentral

Gagne JJ, Glynn RJ, Avorn J, Levin R, Schneeweiss S. A combined comorbidity score predicted mortality in elderly patients better than existing scores. J Clin Epidemiol 2011;64(7):749–759. https://doi.org/10.1016/j.jclinepi.2010.10.004 CrossRefPubMedPubMedCentral

Lewis J. Package ‘ poLCA .’ https://cran.r-project.org/web/packages/poLCA/poLCA.pdf. Published 2016.

Holmes DR, Brennan JM, Rumsfeld JS, et al. Clinical outcomes at 1 year following transcatheter aortic valve replacement. JAMA. 2015;313(10):1019–1028. https://doi.org/10.1001/jama.2015.1474 CrossRefPubMed

Forman DE, Maurer MS, Boyd C, et al. Multimorbidity in Older Adults With Cardiovascular Disease. J Am Coll Cardiol 2018;71(19):2149–2161. https://doi.org/10.1016/j.jacc.2018.03.022 CrossRefPubMedPubMedCentral

Title: Chronic Conditions in Advanced Cardiac Disease: A Cluster Analysis of Transcatheter Aortic Valve Replacement (TAVR)-Treated Patients
Authors: Benjamin S. Wessler, MD, MS
Benjamin C. Koethe, MPH
Paul K. J. Han, MD, MA, MPH
Andrew R. Weintraub, MD
James E. Udelson, MD
Cynthia M. Boyd, MD, MPH
David M. Kent, MD, CM, MS
Publication date: 01-07-2020
Publisher: Springer International Publishing
Keywords: Aortic Valve Replacement
Aortic Valve Replacement
Aortic Valve Replacement
Published in: Journal of General Internal Medicine / Issue 7/2020
Print ISSN: 0884-8734
Electronic ISSN: 1525-1497
DOI: https://doi.org/10.1007/s11606-019-05625-z

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