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Published in: Journal of General Internal Medicine 8/2020

01-08-2020 | Opioids | Original Research

Association between Opioid Prescribing in Medicare and Pharmaceutical Company Gifts by Physician Specialty

Authors: Mara A. G. Hollander, B.A., Julie M. Donohue, PhD, Bradley D. Stein, MD, PhD, Elizabeth E. Krans, MD, MSc, Marian P. Jarlenski, PhD, MPH

Published in: Journal of General Internal Medicine | Issue 8/2020

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Abstract

Background

The association between pharmaceutical industry promotion and physician opioid prescribing is poorly understood. Whether the influence of industry gifts on prescribing varies by specialty is unknown.

Objective

To examine the relationship between opioid-related gifts to physicians and opioid prescribing in the subsequent year across 7 physician specialties.

Design

Panel study using data from 2014 to 2016.

Participants

236,103 unique Medicare Part D physicians (389,622 physician-years) who received any gifts from pharmaceutical companies measured using Open Payments and prescribed opioids in the subsequent year.

Main Measures

Amounts paid by pharmaceutical companies for opioid-related gifts including meals and lodging; quartile of opioid prescribing as a percent of total prescribing compared with other same-specialty physicians.

Key Results

In 2014–2015, 14.1% of physician received opioid-related gifts from the industry with 2.6% receiving > $100. Gifts varied by specialty and were concentrated among two pharmaceutical companies responsible for 60% of the value of opioid-related gifts. Receiving opioid-related gifts was associated with greater prescribing of opioids compared with same-specialty physicians in the next year. Primary care physicians are nearly 3.5 times as likely to be in the highest quartile of prescribing versus the lower quartiles if they were paid ≥ $100. Psychiatrists and neurologists were 7 to 13 times as likely to be in a higher quartile of opioid prescribing compared with colleagues who were paid $0 in the preceding year.

Conclusions

The value of opioid-related gifts given to physicians varies substantially by provider specialty, as does the relationship between payment amounts and prescriber behavior in the following year.
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Literature
2.
go back to reference Dowell D, Haegerich TM, Chou R. CDC Guideline for Prescribing Opioids for Chronic Pain--United States, 2016. JAMA. 2016;315(15):1624-45.CrossRef Dowell D, Haegerich TM, Chou R. CDC Guideline for Prescribing Opioids for Chronic Pain--United States, 2016. JAMA. 2016;315(15):1624-45.CrossRef
3.
go back to reference Hadland SE, Cerda M, Li Y, Krieger MS, Marshall BDL. Association of Pharmaceutical Industry Marketing of Opioid Products to Physicians With Subsequent Opioid Prescribing. JAMA Intern Med 2018;178(6):861-3.CrossRef Hadland SE, Cerda M, Li Y, Krieger MS, Marshall BDL. Association of Pharmaceutical Industry Marketing of Opioid Products to Physicians With Subsequent Opioid Prescribing. JAMA Intern Med 2018;178(6):861-3.CrossRef
4.
go back to reference Hadland SE, Rivera-Aguirre A, Marshall BDL, Cerda M. Association of Pharmaceutical Industry Marketing of Opioid Products With Mortality From Opioid-Related Overdoses. JAMA Netw Open 2019;2(1):e186007.CrossRef Hadland SE, Rivera-Aguirre A, Marshall BDL, Cerda M. Association of Pharmaceutical Industry Marketing of Opioid Products With Mortality From Opioid-Related Overdoses. JAMA Netw Open 2019;2(1):e186007.CrossRef
5.
go back to reference Hadland SE, Krieger MS, Marshall BDL. Industry Payments to Physicians for Opioid Products, 2013-2015. Am J Public Health 2017;107(9):1493-5.CrossRef Hadland SE, Krieger MS, Marshall BDL. Industry Payments to Physicians for Opioid Products, 2013-2015. Am J Public Health 2017;107(9):1493-5.CrossRef
6.
go back to reference Gibbons RV, Landry FJ, Blouch DL, Jones DL, Williams FK, Lucey CR, et al. A comparison of physicians’ and patients’ attitudes toward pharmaceutical industry gifts. J Gen Intern Med 1998;13(3):151-4.CrossRef Gibbons RV, Landry FJ, Blouch DL, Jones DL, Williams FK, Lucey CR, et al. A comparison of physicians’ and patients’ attitudes toward pharmaceutical industry gifts. J Gen Intern Med 1998;13(3):151-4.CrossRef
7.
go back to reference Caudill TS, Johnson MS, Rich EC, McKinney WP. Physicians, pharmaceutical sales representatives, and the cost of prescribing. Arch Fam Med 1996;5(4):201-6.CrossRef Caudill TS, Johnson MS, Rich EC, McKinney WP. Physicians, pharmaceutical sales representatives, and the cost of prescribing. Arch Fam Med 1996;5(4):201-6.CrossRef
8.
go back to reference Dana J, Loewenstein G. A social science perspective on gifts to physicians from industry. JAMA. 2003;290(2):252-5.CrossRef Dana J, Loewenstein G. A social science perspective on gifts to physicians from industry. JAMA. 2003;290(2):252-5.CrossRef
9.
go back to reference Babcock L, Loewenstein G, Issacharoff S. Creating Convergence: Debiasing Biased Litigants. Law Soc Inq 1997;22(4):913-25.CrossRef Babcock L, Loewenstein G, Issacharoff S. Creating Convergence: Debiasing Biased Litigants. Law Soc Inq 1997;22(4):913-25.CrossRef
10.
go back to reference Emanuel G, Thomas K. Top Executives of Insys, an Opioid Company, Are Found Guilty of Racketeering. The New York Times. New York. Emanuel G, Thomas K. Top Executives of Insys, an Opioid Company, Are Found Guilty of Racketeering. The New York Times. New York.
11.
go back to reference Dolmetsch C. Purdue’s Sackler Family Must Face Opioid Suits in New York. Bloomberg. New York. Dolmetsch C. Purdue’s Sackler Family Must Face Opioid Suits in New York. Bloomberg. New York.
12.
go back to reference Hoffman J. Purdue Pharma and Sacklers Reach $270 Million Settlement in Opioid Lawsuit. The New York Times, New York. Hoffman J. Purdue Pharma and Sacklers Reach $270 Million Settlement in Opioid Lawsuit. The New York Times, New York.
13.
go back to reference Opioid Manufacturer Insys Therapeutics Agrees to Enter $225 Million Global Resolution of Criminal and Civil Investigations. Company Admits Illegal Conduct Regarding Promotion of Subsys, a Powerful Opioid Painkiller. 19-621 ed: Department of Justice Office of Public Affairs; 2019. Opioid Manufacturer Insys Therapeutics Agrees to Enter $225 Million Global Resolution of Criminal and Civil Investigations. Company Admits Illegal Conduct Regarding Promotion of Subsys, a Powerful Opioid Painkiller. 19-621 ed: Department of Justice Office of Public Affairs; 2019.
14.
go back to reference Magnus SA. Physicians’ financial incentives in five dimensions: a conceptual framework for HMO managers. Health Care Manag Rev 1999;24(1):57-72. Magnus SA. Physicians’ financial incentives in five dimensions: a conceptual framework for HMO managers. Health Care Manag Rev 1999;24(1):57-72.
15.
go back to reference Levy B, Paulozzi L, Mack KA, Jones CM. Trends in Opioid Analgesic-Prescribing Rates by Specialty, U.S., 2007-2012 Am J Prev Med 2015;49(3):409-13.CrossRef Levy B, Paulozzi L, Mack KA, Jones CM. Trends in Opioid Analgesic-Prescribing Rates by Specialty, U.S., 2007-2012 Am J Prev Med 2015;49(3):409-13.CrossRef
20.
go back to reference Opioids: Brand names, generic names & street names. It Matters Colorado. Opioids: Brand names, generic names & street names. It Matters Colorado.
25.
go back to reference Tigas M, Jones RG, Ornstein C, Groeger L. Dollars for Docs NPI/Open Payments Crosswalk. Tigas M, Jones RG, Ornstein C, Groeger L. Dollars for Docs NPI/Open Payments Crosswalk.
26.
go back to reference Jones RG, Ornstein C. Matching Industry Payments to Medicare Prescribing Patterns: An Analysis. ProPublica, Manhattan; 2016. Jones RG, Ornstein C. Matching Industry Payments to Medicare Prescribing Patterns: An Analysis. ProPublica, Manhattan; 2016.
27.
go back to reference DeJong C, Aguilar T, Tseng CW, Lin GA, Boscardin WJ, Dudley RA. Pharmaceutical Industry-Sponsored Meals and Physician Prescribing Patterns for Medicare Beneficiaries. JAMA Intern Med 2016;176(8):1114-22.CrossRef DeJong C, Aguilar T, Tseng CW, Lin GA, Boscardin WJ, Dudley RA. Pharmaceutical Industry-Sponsored Meals and Physician Prescribing Patterns for Medicare Beneficiaries. JAMA Intern Med 2016;176(8):1114-22.CrossRef
28.
go back to reference PhRMA. Code on Interactions with Healthcare Professionals. 2008. PhRMA. Code on Interactions with Healthcare Professionals. 2008.
29.
go back to reference Williams R. Generalized ordered logit/partial proportional odds models for ordinal dependent variables. Stata J 2006;6(1):58-82.CrossRef Williams R. Generalized ordered logit/partial proportional odds models for ordinal dependent variables. Stata J 2006;6(1):58-82.CrossRef
30.
go back to reference Armstrong RA. When to use the Bonferroni correction. Ophthalmic Physiol Opt 2014;34(5):502-8.CrossRef Armstrong RA. When to use the Bonferroni correction. Ophthalmic Physiol Opt 2014;34(5):502-8.CrossRef
32.
go back to reference Fleischman W, Agrawal S, King M, Venkatesh AK, Krumholz HM, McKee D, et al. Association between payments from manufacturers of pharmaceuticals to physicians and regional prescribing: cross sectional ecological study. BMJ 2016;354. Fleischman W, Agrawal S, King M, Venkatesh AK, Krumholz HM, McKee D, et al. Association between payments from manufacturers of pharmaceuticals to physicians and regional prescribing: cross sectional ecological study. BMJ 2016;354.
33.
go back to reference Lo B, Grady D. Payments to Physicians: Does the Amount of Money Make a Difference? JAMA. 2017;317(17). Lo B, Grady D. Payments to Physicians: Does the Amount of Money Make a Difference? JAMA. 2017;317(17).
34.
go back to reference Wood SF, Podrasky J, McMonagle MA, Raveendran J, Bysshe T, Hogenmiller A, et al. Influence of pharmaceutical marketing on Medicare prescriptions in the District of Columbia. PLoS One 2017;12(10):e0186060.CrossRef Wood SF, Podrasky J, McMonagle MA, Raveendran J, Bysshe T, Hogenmiller A, et al. Influence of pharmaceutical marketing on Medicare prescriptions in the District of Columbia. PLoS One 2017;12(10):e0186060.CrossRef
35.
go back to reference Yeh JS, Franklin JM, Avorn J, Landon J, Kesselheim AS. Association of Industry Payments to Physicians With the Prescribing of Brand-name Statins in Massachusetts. JAMA Intern Med 2016;176(6):763-8.CrossRef Yeh JS, Franklin JM, Avorn J, Landon J, Kesselheim AS. Association of Industry Payments to Physicians With the Prescribing of Brand-name Statins in Massachusetts. JAMA Intern Med 2016;176(6):763-8.CrossRef
36.
go back to reference Dufour R, Joshi AV, Pasquale MK, Schaaf D, Mardekian J, Andrews GA, et al. The prevalence of diagnosed opioid abuse in commercial and Medicare managed care populations. Pain Pract 2014;14(3):E106-15.CrossRef Dufour R, Joshi AV, Pasquale MK, Schaaf D, Mardekian J, Andrews GA, et al. The prevalence of diagnosed opioid abuse in commercial and Medicare managed care populations. Pain Pract 2014;14(3):E106-15.CrossRef
37.
go back to reference Anderson KK, Hendrick F, McClair V. National Trends in High-dose Chronic Opioid Utilization among Dually Eligible and Medicare-only Beneficiaries (2006-2015). Data Analysis Brief: Center for Medicare and Medicaid Services; 2018. Anderson KK, Hendrick F, McClair V. National Trends in High-dose Chronic Opioid Utilization among Dually Eligible and Medicare-only Beneficiaries (2006-2015). Data Analysis Brief: Center for Medicare and Medicaid Services; 2018.
38.
go back to reference Meara E, Horwitz JR, Powell W, McClelland L, Zhou W, O’Malley AJ, et al. State Legal Restrictions and Prescription-Opioid Use among Disabled Adults. N Engl J Med 2016;375(1):44-53.CrossRef Meara E, Horwitz JR, Powell W, McClelland L, Zhou W, O’Malley AJ, et al. State Legal Restrictions and Prescription-Opioid Use among Disabled Adults. N Engl J Med 2016;375(1):44-53.CrossRef
39.
go back to reference Carey CM, Jena AB, Barnett ML. Patterns of Potential Opioid Misuse and Subsequent Adverse Outcomes in Medicare, 2008 to 2012. Ann Intern Med 2018;168(12):837-45.CrossRef Carey CM, Jena AB, Barnett ML. Patterns of Potential Opioid Misuse and Subsequent Adverse Outcomes in Medicare, 2008 to 2012. Ann Intern Med 2018;168(12):837-45.CrossRef
40.
go back to reference Boccuti C, Swoope C, Damico A, Neuman T. Medicare Patients’ Access to Physicians: A Synthesis of the Evidence. Kaiser Family Foundation, San Francisco; 2013. Boccuti C, Swoope C, Damico A, Neuman T. Medicare Patients’ Access to Physicians: A Synthesis of the Evidence. Kaiser Family Foundation, San Francisco; 2013.
41.
go back to reference Tringale KR, Marshall D, Mackey TK, Connor M, Murphy JD, Hattangadi-Gluth JA. Types and Distribution of Payments From Industry to Physicians in 2015. JAMA. 2017;317(17):1774-84.CrossRef Tringale KR, Marshall D, Mackey TK, Connor M, Murphy JD, Hattangadi-Gluth JA. Types and Distribution of Payments From Industry to Physicians in 2015. JAMA. 2017;317(17):1774-84.CrossRef
42.
go back to reference Cialdini RB. Influence: The Psychology of Persuasion: Harper Business; 1993. Cialdini RB. Influence: The Psychology of Persuasion: Harper Business; 1993.
43.
go back to reference Katz D, Caplan AL, Merz JF. All Gifts Large and Small: Toward an Understanding of the Ethics of Pharmaceutical Industry Gift Giving. Am J Bioeth 2003;3(3):39-46.CrossRef Katz D, Caplan AL, Merz JF. All Gifts Large and Small: Toward an Understanding of the Ethics of Pharmaceutical Industry Gift Giving. Am J Bioeth 2003;3(3):39-46.CrossRef
44.
go back to reference Manchanda P, Xie Y, Youn N. The Role of Targeted Communication and Contagion in Product Adoption. Mark Sci 2008;27(6):961-76.CrossRef Manchanda P, Xie Y, Youn N. The Role of Targeted Communication and Contagion in Product Adoption. Mark Sci 2008;27(6):961-76.CrossRef
45.
go back to reference Commercial Access to Physicians: Medical Industry Sales Reps Accessibility to U.S. Physicians. Irvine, CA: SK&A; 2017. Commercial Access to Physicians: Medical Industry Sales Reps Accessibility to U.S. Physicians. Irvine, CA: SK&A; 2017.
46.
go back to reference Larkin I, Ang D, Steinhart J, Chao M, Patterson M, Sah S, et al. Association Between Academic Medical Center Pharmaceutical Detailing Policies and Physician Prescribing. JAMA. 2017;317(17):1785-95.CrossRef Larkin I, Ang D, Steinhart J, Chao M, Patterson M, Sah S, et al. Association Between Academic Medical Center Pharmaceutical Detailing Policies and Physician Prescribing. JAMA. 2017;317(17):1785-95.CrossRef
Metadata
Title
Association between Opioid Prescribing in Medicare and Pharmaceutical Company Gifts by Physician Specialty
Authors
Mara A. G. Hollander, B.A.
Julie M. Donohue, PhD
Bradley D. Stein, MD, PhD
Elizabeth E. Krans, MD, MSc
Marian P. Jarlenski, PhD, MPH
Publication date
01-08-2020
Publisher
Springer International Publishing
Keywords
Opioids
Opioids
Published in
Journal of General Internal Medicine / Issue 8/2020
Print ISSN: 0884-8734
Electronic ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-019-05470-0

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