Skip to main content
Top
Published in: Journal of General Internal Medicine 4/2013

01-04-2013 | Original Research

Receipt of High Risk Medications among Elderly Enrollees in Medicare Advantage Plans

Authors: Danya M. Qato, PharmD, MPH, Amal N. Trivedi, MD, MPH

Published in: Journal of General Internal Medicine | Issue 4/2013

Login to get access

ABSTRACT

BACKGROUND

Since 2005, the Centers for Medicare and Medicaid Services (CMS) has required all Medicare Advantage (MA) plans to report prescribing rates of high risk medications (HRM).

OBJECTIVE

To determine predictors of receipt of HRMs, as defined by the National Committee for Quality Assurance’s “Drugs to Avoid in the Elderly” quality indicator, in a national sample of MA enrollees.

DESIGN AND PARTICIPANTS

Retrospective analysis of Healthcare Effectiveness Data and Information Set (HEDIS) data for 6,204,824 enrollees, aged 65 years or older, enrolled in 415 MA plans in 2009. To identify predictors of HRM use, we fit generalized linear models and modeled outcomes on the risk-difference scale.

MAIN OUTCOME MEASURES

Receipt or non-receipt of one or two HRMs.

KEY RESULTS

Approximately 21 % of MA enrollees received at least one HRM and 4.8 % received at least two. In fully adjusted models, females had a 10.6 (95 % CI: 10.0–11.2) higher percentage point rate of receipt than males, and residence in any of the Southern United States divisions was associated with a greater than 10 percentage point higher rate, as compared with the reference New England division. Higher rates were also observed among enrollees with low personal income (6.5 percentage points, 95 % CI: 5.5–7.5), relative to those without low income and those residing in areas in the lowest quintile of socioeconomic status (2.7 points, 95 % CI: 1.9–3.4) relative to persons residing in the highest quintile. Enrollees ≥ 85 years old, black enrollees, and other minority groups were less likely to receive these medications. Over 38 % of MA enrollees residing in the hospital referral region of Albany, Georgia received at least one HRM, a rate four times higher than the referral region with the lowest rate (Mason City, Iowa).

CONCLUSIONS

Use of HRMs among MA enrollees varies widely by geographic region. Persons living in the Southern region of the U.S., whites, women, and persons of low personal income and socioeconomic status are more likely to receive HRMs.
Appendix
Available only for authorised users
Literature
1.
go back to reference Institute of Medicine (U.S.). Aspden P, Wolcott JA, Bootman JL, Cronenwett LR, Eds. Preventing Medication Errors. Committee on Identifying and Preventing Medication Errors. . Washington: National Academies Press; 2007. Institute of Medicine (U.S.). Aspden P, Wolcott JA, Bootman JL, Cronenwett LR, Eds. Preventing Medication Errors. Committee on Identifying and Preventing Medication Errors. . Washington: National Academies Press; 2007.
2.
go back to reference Hohl CM, Zed PJ, Brubacher JR, Abu-Laban RB, Loewen PS, Purssell RA. Do emergency physicians attribute drug-related emergency department visits to medication-related problems? Ann Emerg Med. 2010;55(6):493–502. e494.PubMedCrossRef Hohl CM, Zed PJ, Brubacher JR, Abu-Laban RB, Loewen PS, Purssell RA. Do emergency physicians attribute drug-related emergency department visits to medication-related problems? Ann Emerg Med. 2010;55(6):493–502. e494.PubMedCrossRef
3.
go back to reference Hohl CM, Dankoff J, Colacone A, Afilalo M. Polypharmacy, adverse drug-related events, and potential adverse drug interactions in elderly patients presenting to an emergency department. Ann Emerg Med. 2001;38(6):666–671.PubMedCrossRef Hohl CM, Dankoff J, Colacone A, Afilalo M. Polypharmacy, adverse drug-related events, and potential adverse drug interactions in elderly patients presenting to an emergency department. Ann Emerg Med. 2001;38(6):666–671.PubMedCrossRef
4.
go back to reference Bond CA, Raehl CL. 2006 national clinical pharmacy services survey: clinical pharmacy services, collaborative drug management, medication errors, and pharmacy technology. Pharmacotherapy. 2008;28(1):1–13.PubMedCrossRef Bond CA, Raehl CL. 2006 national clinical pharmacy services survey: clinical pharmacy services, collaborative drug management, medication errors, and pharmacy technology. Pharmacotherapy. 2008;28(1):1–13.PubMedCrossRef
5.
go back to reference Gurwitz JH, Field TS, Avorn J, et al. Incidence and preventability of adverse drug events in nursing homes. Am J Med. 2000;109(2):87–94.PubMedCrossRef Gurwitz JH, Field TS, Avorn J, et al. Incidence and preventability of adverse drug events in nursing homes. Am J Med. 2000;109(2):87–94.PubMedCrossRef
6.
go back to reference Cahir C, Fahey T, Teeling M, Teljeur C, Feely J, Bennett K. Potentially inappropriate prescribing and cost outcomes for older people: a national population study. Br J Clin Pharmacol. 2010;69(5):543–552.PubMedCrossRef Cahir C, Fahey T, Teeling M, Teljeur C, Feely J, Bennett K. Potentially inappropriate prescribing and cost outcomes for older people: a national population study. Br J Clin Pharmacol. 2010;69(5):543–552.PubMedCrossRef
7.
go back to reference Budnitz DS, Shehab N, Kegler SR, Richards CL. Medication use leading to emergency department visits for adverse drug events in older adults. Ann Intern Med. 2007;147(11):755–U726.PubMed Budnitz DS, Shehab N, Kegler SR, Richards CL. Medication use leading to emergency department visits for adverse drug events in older adults. Ann Intern Med. 2007;147(11):755–U726.PubMed
8.
go back to reference Fick D, Semla T, Beizer J, et al. American Geriatrics Society Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc. 2012;60(4):616–631.CrossRef Fick D, Semla T, Beizer J, et al. American Geriatrics Society Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc. 2012;60(4):616–631.CrossRef
9.
go back to reference Zhan C, Sangl J, Bierman AS, et al. Potentially inappropriate medication use in the community-dwelling elderly: findings from the 1996 Medical Expenditure Panel Survey. JAMA. 2001;286(22):2823–2829.PubMedCrossRef Zhan C, Sangl J, Bierman AS, et al. Potentially inappropriate medication use in the community-dwelling elderly: findings from the 1996 Medical Expenditure Panel Survey. JAMA. 2001;286(22):2823–2829.PubMedCrossRef
10.
go back to reference Lichtenberg FR, Sun SX. The impact of medicare part D on prescription drug use by the elderly. Health Aff. 2007;26(6):1735–1744.CrossRef Lichtenberg FR, Sun SX. The impact of medicare part D on prescription drug use by the elderly. Health Aff. 2007;26(6):1735–1744.CrossRef
11.
go back to reference Fu AZ, Tang AS, Wang N, Du DT, Jiang JZ. Effect of Medicare Part D on potentially inappropriate medication use by older adults. J Am Geriatr Soc. 2010;58(5):944–949.PubMedCrossRef Fu AZ, Tang AS, Wang N, Du DT, Jiang JZ. Effect of Medicare Part D on potentially inappropriate medication use by older adults. J Am Geriatr Soc. 2010;58(5):944–949.PubMedCrossRef
12.
go back to reference Riley G, Zarabozo C. Trends in the health status of medicare risk contract enrollees. Health Care Financ Rev. Winter. 2006;28(2):81–95. Riley G, Zarabozo C. Trends in the health status of medicare risk contract enrollees. Health Care Financ Rev. Winter. 2006;28(2):81–95.
13.
go back to reference Stockl KM, Le L, Zhang S, Harada AS. Clinical and economic outcomes associated with potentially inappropriate prescribing in the elderly. Am J Manag Care. 2010;16(1):e1–10.PubMed Stockl KM, Le L, Zhang S, Harada AS. Clinical and economic outcomes associated with potentially inappropriate prescribing in the elderly. Am J Manag Care. 2010;16(1):e1–10.PubMed
14.
go back to reference Chrischilles EA, VanGilder R, Wright K, Kelly M, Wallace RB. Inappropriate medication use as a risk factor for self-reported adverse drug effects in older adults. J Am Geriatr Soc. 2009;57(6):1000–1006.PubMedCrossRef Chrischilles EA, VanGilder R, Wright K, Kelly M, Wallace RB. Inappropriate medication use as a risk factor for self-reported adverse drug effects in older adults. J Am Geriatr Soc. 2009;57(6):1000–1006.PubMedCrossRef
15.
go back to reference Berdot S, Bertrand M, Dartigues JF, Fourrier A, Tavernier B, Ritchie K, et al. Inappropriate medication use and risk of falls—a prospective study in a large community-dwelling elderly cohort. BMC Geriatr. 2009;9(1):30.PubMedCrossRef Berdot S, Bertrand M, Dartigues JF, Fourrier A, Tavernier B, Ritchie K, et al. Inappropriate medication use and risk of falls—a prospective study in a large community-dwelling elderly cohort. BMC Geriatr. 2009;9(1):30.PubMedCrossRef
17.
go back to reference Pugh MJV, Hanlon JT, Zeber JE, Bierman A, Cornell J, Berlowitz DR. Assessing potentially inappropriate prescribing in the elderly veterans affairs population using the HEDIS 2006 quality measure. J Manag Care Pharm. 2006;12(7):537–545.PubMed Pugh MJV, Hanlon JT, Zeber JE, Bierman A, Cornell J, Berlowitz DR. Assessing potentially inappropriate prescribing in the elderly veterans affairs population using the HEDIS 2006 quality measure. J Manag Care Pharm. 2006;12(7):537–545.PubMed
18.
go back to reference The Dartmouth atlas of health care, 1999. Chicago Ill.: American Hospital Publishing; 1999. The Dartmouth atlas of health care, 1999. Chicago Ill.: American Hospital Publishing; 1999.
19.
go back to reference Landon BE, Keating NL, Barnett ML, et al. Variation in patient-sharing networks of physicians across the United States. JAMA. 2012;308(3):265–273.PubMedCrossRef Landon BE, Keating NL, Barnett ML, et al. Variation in patient-sharing networks of physicians across the United States. JAMA. 2012;308(3):265–273.PubMedCrossRef
20.
go back to reference Zhang Y, Baicker K, Newhouse JP. Geographic variation in the quality of prescribing. N Engl J Med. 2010;363(21):1985–1988.PubMedCrossRef Zhang Y, Baicker K, Newhouse JP. Geographic variation in the quality of prescribing. N Engl J Med. 2010;363(21):1985–1988.PubMedCrossRef
21.
go back to reference Baicker K, Chandra A, Skinner JS, Wennberg JE. Who you are and where you live: how race and geography affect the treatment of medicare beneficiaries. Health Aff. 2004;Suppl Variation:VAR33-44. Baicker K, Chandra A, Skinner JS, Wennberg JE. Who you are and where you live: how race and geography affect the treatment of medicare beneficiaries. Health Aff. 2004;Suppl Variation:VAR33-44.
22.
go back to reference Koroukian SM, Dahman B, Copeland G, Bradley CJ. The utility of the state buy-in variable in the Medicare denominator file to identify dually eligible Medicare-Medicaid beneficiaries: a validation study. Health Serv Res. 2010;45(1):265–282.PubMedCrossRef Koroukian SM, Dahman B, Copeland G, Bradley CJ. The utility of the state buy-in variable in the Medicare denominator file to identify dually eligible Medicare-Medicaid beneficiaries: a validation study. Health Serv Res. 2010;45(1):265–282.PubMedCrossRef
24.
go back to reference Yang HWK, Simoni-Wastila L, Zuckerman IH, Stuart B. Benzodiazepine use and expenditures for Medicare beneficiaries and the implications of Medicare Part D exclusions. Psychiatr Serv. 2008;59(4):384–391.PubMedCrossRef Yang HWK, Simoni-Wastila L, Zuckerman IH, Stuart B. Benzodiazepine use and expenditures for Medicare beneficiaries and the implications of Medicare Part D exclusions. Psychiatr Serv. 2008;59(4):384–391.PubMedCrossRef
25.
go back to reference Goulding MR. Inappropriate medication prescribing for elderly ambulatory care patients. Arch Intern Med. 2004;164(3):305–312.PubMedCrossRef Goulding MR. Inappropriate medication prescribing for elderly ambulatory care patients. Arch Intern Med. 2004;164(3):305–312.PubMedCrossRef
26.
go back to reference Morabia A, Fabre J, Dunand JP. The influence of patient and physician gender on prescription of psychotropic drugs. J Clin Epidemiol. 1992;45(2):111–116.PubMedCrossRef Morabia A, Fabre J, Dunand JP. The influence of patient and physician gender on prescription of psychotropic drugs. J Clin Epidemiol. 1992;45(2):111–116.PubMedCrossRef
28.
go back to reference Bierman AS, Pugh MJ, Dhalla I, et al. Sex differences in inappropriate prescribing among elderly veterans. Am J Geriatr Pharmacother. 2007;5(2):147–161.PubMedCrossRef Bierman AS, Pugh MJ, Dhalla I, et al. Sex differences in inappropriate prescribing among elderly veterans. Am J Geriatr Pharmacother. 2007;5(2):147–161.PubMedCrossRef
29.
go back to reference Bao Y, Alexopoulos GS, Casalino LP, et al. Collaborative depression care management and disparities in depression treatment and outcomes. Arch Gen Psychiatr. 2011;68(6):627–636.PubMedCrossRef Bao Y, Alexopoulos GS, Casalino LP, et al. Collaborative depression care management and disparities in depression treatment and outcomes. Arch Gen Psychiatr. 2011;68(6):627–636.PubMedCrossRef
30.
go back to reference Alegria M, Chatterji P, Wells K, et al. Disparity in Depression Treatment Among Racial and Ethnic Minority Populations in the United States. Psychiatr Serv. 2008;59(11):1264–1272.PubMedCrossRef Alegria M, Chatterji P, Wells K, et al. Disparity in Depression Treatment Among Racial and Ethnic Minority Populations in the United States. Psychiatr Serv. 2008;59(11):1264–1272.PubMedCrossRef
31.
go back to reference Keyes KM, Hatzenbuehler ML, Alberti P, Narrow WE, Grant BF, Hasin DS. Service utilization differences for Axis I psychiatric and substance use disorders between white and black adults. Psychiatr Serv. 2008;59(8):893–901.PubMedCrossRef Keyes KM, Hatzenbuehler ML, Alberti P, Narrow WE, Grant BF, Hasin DS. Service utilization differences for Axis I psychiatric and substance use disorders between white and black adults. Psychiatr Serv. 2008;59(8):893–901.PubMedCrossRef
34.
go back to reference Ogden CL, Flegal KM. Prescription Medication Use Among Normal Weight, Overweight, and Obese Adults, United States, 2005–2008. Ann Epidemiol. 2012;22(2):8p. Ogden CL, Flegal KM. Prescription Medication Use Among Normal Weight, Overweight, and Obese Adults, United States, 2005–2008. Ann Epidemiol. 2012;22(2):8p.
35.
go back to reference Zhang YJ, Liu WW, Wang JB, Guo JJ. Potentially inappropriate medication use among older adults in the USA in 2007. Age Ageing. 2011;40(3):398–401.PubMedCrossRef Zhang YJ, Liu WW, Wang JB, Guo JJ. Potentially inappropriate medication use among older adults in the USA in 2007. Age Ageing. 2011;40(3):398–401.PubMedCrossRef
36.
go back to reference Wang YR, Pauly MV. Spillover effects of restrictive drug formularies on physician prescribing behavior: Evidence from Medicaid. J Econ Manage Strat Fal. 2005;14(3):755–773.CrossRef Wang YR, Pauly MV. Spillover effects of restrictive drug formularies on physician prescribing behavior: Evidence from Medicaid. J Econ Manage Strat Fal. 2005;14(3):755–773.CrossRef
37.
go back to reference Joyce GF, Escarce JJ, Solomon MD, Goldman DP. Employer drug benefit plans and spending on prescription drugs. JAMA. 2002;288(14):1733–1739.PubMedCrossRef Joyce GF, Escarce JJ, Solomon MD, Goldman DP. Employer drug benefit plans and spending on prescription drugs. JAMA. 2002;288(14):1733–1739.PubMedCrossRef
38.
go back to reference Fu AZ, Liu GG, Christensen DB. Inappropriate medication use and health outcomes in the elderly. J Am Geriatr Soc. 2004;52(11):1934–1939.PubMedCrossRef Fu AZ, Liu GG, Christensen DB. Inappropriate medication use and health outcomes in the elderly. J Am Geriatr Soc. 2004;52(11):1934–1939.PubMedCrossRef
39.
go back to reference Bao YH, Shao HB, Bishop TF, Schackman BR, Bruce ML. Inappropriate Medication in a National Sample of US Elderly Patients Receiving Home Health Care. J Gen Intern Med. 2012;27(3):304–310.PubMedCrossRef Bao YH, Shao HB, Bishop TF, Schackman BR, Bruce ML. Inappropriate Medication in a National Sample of US Elderly Patients Receiving Home Health Care. J Gen Intern Med. 2012;27(3):304–310.PubMedCrossRef
40.
go back to reference Garcia-Gollarte F, Baleriola-Julvez J, Ferrero-Lopez I, Cruz-Jentoft AJ. Inappropriate Drug Prescription at Nursing Home Admission. J Am Med Dir Assoc. Jan 2012;13(1). Garcia-Gollarte F, Baleriola-Julvez J, Ferrero-Lopez I, Cruz-Jentoft AJ. Inappropriate Drug Prescription at Nursing Home Admission. J Am Med Dir Assoc. Jan 2012;13(1).
41.
go back to reference Parsons C, Johnston S, Mathie E, et al. Potentially Inappropriate Prescribing in Older People with Dementia in Care Homes A Retrospective Analysis. Drugs Aging. 2012;29(2):143–155.PubMedCrossRef Parsons C, Johnston S, Mathie E, et al. Potentially Inappropriate Prescribing in Older People with Dementia in Care Homes A Retrospective Analysis. Drugs Aging. 2012;29(2):143–155.PubMedCrossRef
42.
go back to reference Ryan C, O’Mahony D, Kennedy J, Weedle P, Byrne S. Potentially inappropriate prescribing in an Irish elderly population in primary care. Br J Clin Pharmacol. 2009;68(6):936–947.PubMedCrossRef Ryan C, O’Mahony D, Kennedy J, Weedle P, Byrne S. Potentially inappropriate prescribing in an Irish elderly population in primary care. Br J Clin Pharmacol. 2009;68(6):936–947.PubMedCrossRef
44.
go back to reference Garfinkel D, Mangin D. Feasibility study of a systematic approach for discontinuation of multiple medications in older adults: addressing polypharmacy. Arch Intern Med. 2010;170(18):1648–1654.PubMedCrossRef Garfinkel D, Mangin D. Feasibility study of a systematic approach for discontinuation of multiple medications in older adults: addressing polypharmacy. Arch Intern Med. 2010;170(18):1648–1654.PubMedCrossRef
46.
go back to reference Avorn J. Improving drug use in elderly patients: getting to the next level. JAMA. 2001;286(22):2866–2868.PubMedCrossRef Avorn J. Improving drug use in elderly patients: getting to the next level. JAMA. 2001;286(22):2866–2868.PubMedCrossRef
Metadata
Title
Receipt of High Risk Medications among Elderly Enrollees in Medicare Advantage Plans
Authors
Danya M. Qato, PharmD, MPH
Amal N. Trivedi, MD, MPH
Publication date
01-04-2013
Publisher
Springer-Verlag
Published in
Journal of General Internal Medicine / Issue 4/2013
Print ISSN: 0884-8734
Electronic ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-012-2244-9

Other articles of this Issue 4/2013

Journal of General Internal Medicine 4/2013 Go to the issue

Healing Arts: Materia Medica

Hiding Behind the Hippocratic Oath

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.