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01-03-2015 | 2014 SSAT Poster Presentation

High-Protein Diet Improves Postoperative Weight Gain After Massive Small-Bowel Resection

Authors: Raphael C. Sun, Pamela M. Choi, Jose Diaz-Miron, Joshua Sommovilla, Jun Guo, Christopher R. Erwin, Brad W. Warner

Published in: Journal of Gastrointestinal Surgery | Issue 3/2015

Abstract

Introduction

Short bowel syndrome (SBS) is a morbid clinical condition that results from massive small-bowel resection (SBR). After SBR, there is a dramatic weight loss in the acute postoperative period. Our aim was to determine the impact of a high-protein diet (HPD) on weight gain and body composition in mice after SBR.

Methods

C57BL/6 mice underwent 50 % proximal SBR. Postoperatively, mice were randomly selected to receive standard rodent liquid diet (LD) (n = 6) or an isocaloric HPD (n = 9) for 28 days. Mice weights were recorded daily. Body composition analyses were obtained weekly. Student’s t test was used for statistical comparisons with p < 0.05 considered significant.

Results

Mice that were fed HPD after SBR returned to baseline weight on average at postoperative day (POD) 8 versus mice that were fed LD that returned to baseline weight on average at POD 22. Total fat mass and lean mass were significantly greater by POD 14 within the HPD group. Both groups of mice demonstrated normal structural adaptation.

Conclusion

HPD results in greater weight gain and improved body composition in mice after SBR. This finding may be clinically important for patients with SBS since improved weight gain may reduce the time needed for parenteral nutrition.

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Title: High-Protein Diet Improves Postoperative Weight Gain After Massive Small-Bowel Resection
Authors: Raphael C. Sun
Pamela M. Choi
Jose Diaz-Miron
Joshua Sommovilla
Jun Guo
Christopher R. Erwin
Brad W. Warner
Publication date: 01-03-2015
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 3/2015
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-014-2715-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

High-Protein Diet Improves Postoperative Weight Gain After Massive Small-Bowel Resection

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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