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01-04-2014 | Case Report

Chronic Pancreatitis and Primary Sclerosing Cholangitis—First Report of Intrahepatic Autologous Islet Transplantation

Authors: Ling-jia Wang, Sona Young, Ryosuke Misawa, Ruba Azzam, Xiaojun Wang, Karolina Gołąb, Olivia Cochet, Omid Savari, Martin Tibudan, J. Michael Millis, Jeffrey B. Matthews, Piotr Witkowski

Published in: Journal of Gastrointestinal Surgery | Issue 4/2014

Abstract

Background

We are reporting first successful intrahepatic autologous islet transplantation after total pancreatectomy in a patient with chronic pancreatitis and primary sclerosing cholangitis.

Methods

Total pancreatectomy and subsequent islet autotransplantation were performed in a 16-year-old boy with intractable pain due to chronic pancreatitis in the setting of ulcerative colitis and primary sclerosing cholangitis (PSC). Liver biopsy revealed PSC with focal bridging fibrosis. The pancreas was surgically removed and digested, and islets were isolated, highly purified, and infused intraportally.

Results

Over 18-month follow-up, the patient did not show progression of chronic liver disease or signs of portal hypertension. Magnetic resonance cholangiopancreatography revealed no new changes, and liver biopsy did not show progression of the periportal fibrosis. Pain medication was weaned over 12 months at which time glycemic control was excellent without exogenous insulin supplementation. HbgA1c was 5.9. Fifteen months after the procedure, stimulation with a mixed meal led to a fourfold increase of serum C-peptide and an eightfold increase of insulin level.

Conclusion

Pancreatic autologous islets can be successfully transplanted into a liver affected by PSC without compromising hepatic or graft function. Durability of the procedure may be limited in the future by the natural course of the liver injury caused by PSC.

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Title: Chronic Pancreatitis and Primary Sclerosing Cholangitis—First Report of Intrahepatic Autologous Islet Transplantation
Authors: Ling-jia Wang
Sona Young
Ryosuke Misawa
Ruba Azzam
Xiaojun Wang
Karolina Gołąb
Olivia Cochet
Omid Savari
Martin Tibudan
J. Michael Millis
Jeffrey B. Matthews
Piotr Witkowski
Publication date: 01-04-2014
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 4/2014
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-013-2414-z

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Springer Medicine

Chronic Pancreatitis and Primary Sclerosing Cholangitis—First Report of Intrahepatic Autologous Islet Transplantation

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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