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01-04-2013 | Original Article

Prognostic Significance of Tumor Doubling Time in Mass-Forming Type Cholangiocarcinoma

Authors: Agostino Maria De Rose, Alessandro Cucchetti, Gennaro Clemente, Francesco Ardito, Ivo Giovannini, Giorgio Ercolani, Felice Giuliante, Antonio Daniele Pinna, Gennaro Nuzzo

Published in: Journal of Gastrointestinal Surgery | Issue 4/2013

Abstract

Objective

The aim of this study was to determine the prognostic significance of the preoperatively assessed tumor doubling time (DT) in patients undergoing liver resection for mass-forming intrahepatic cholangiocarcinoma (IHC).

Methods

We evaluated 79 patients who underwent curative resection for IHC, and in whom the same imaging technique was preoperatively available in two consecutive occasions, to allow the calculation of the DT. The influence of DT and other clinical and pathological variables on tumor recurrence and patient survival was determined by the Kaplan–Meier method and uni- and multivariate analysis.

Results

Median overall survival was 40 months; 1-, 3-, and 5-year survival rates were 86.1, 55.1, and 35.1 %, respectively. Median disease-free survival was 17 months; 1-, 3-, and 5-year disease-free survival rates were 62.0, 29.1, and 23.3 %, respectively. At univariate analysis, DT <70 days (p < 0.001) and advanced tumor stage (p = 0.024) were associated with worse overall survival and maintained significance at multivariate analysis.

Conclusions

DT is a clinically useful parameter to estimate the prognosis of “mass-forming” IHC in patients undergoing liver resection.

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Title: Prognostic Significance of Tumor Doubling Time in Mass-Forming Type Cholangiocarcinoma
Authors: Agostino Maria De Rose
Alessandro Cucchetti
Gennaro Clemente
Francesco Ardito
Ivo Giovannini
Giorgio Ercolani
Felice Giuliante
Antonio Daniele Pinna
Gennaro Nuzzo
Publication date: 01-04-2013
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 4/2013
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-012-2129-6

At a glance: The STEP trials

Springer Medicine

Prognostic Significance of Tumor Doubling Time in Mass-Forming Type Cholangiocarcinoma

Abstract

Objective

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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