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01-04-2012 | Case Report

Littoral Cell Angioma and Angiosarcoma of the Spleen: Report of Two Cases in Siblings and Review of the Literature

Authors: Michael Kranzfelder, Margit Bauer, Thomas Richter, Martina Rudelius, Martin Huth, Peter Wagner, Helmut Friess, Josef Stadler

Published in: Journal of Gastrointestinal Surgery | Issue 4/2012

Excerpt

Littoral cell angioma (LCA), a primary benign tumour of the spleen, was first described by Falk et al. in 1991.1 Arising from the normal littoral cells lining the sinus channels of the splenic red pulp due to yet unknown stimuli,2 LCA presents with intermediate features between those of endothelial and histiocytic cells. The most frequent clinical sign is splenomegaly. A malignant transformation to littoral cell angiosarcoma is very rare;3‐5 however, an association with other malignancies has been reported recently.6 …

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Title: Littoral Cell Angioma and Angiosarcoma of the Spleen: Report of Two Cases in Siblings and Review of the Literature
Authors: Michael Kranzfelder
Margit Bauer
Thomas Richter
Martina Rudelius
Martin Huth
Peter Wagner
Helmut Friess
Josef Stadler
Publication date: 01-04-2012
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 4/2012
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-011-1773-6

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Littoral Cell Angioma and Angiosarcoma of the Spleen: Report of Two Cases in Siblings and Review of the Literature

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