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Journal of Gastrointestinal Surgery
Published in: Journal of Gastrointestinal Surgery 9/2011

01-09-2011 | Original Article

The Changes of Pro-opiomelanocortin Neurons in Type 2 Diabetes Mellitus Rats After Ileal Transposition: The Role of POMC Neurons

Authors: Weijie Chen, Zhibo Yan, Shaozhuang Liu, Guangyong Zhang, Dong Sun, Sanyuan Hu

Published in: Journal of Gastrointestinal Surgery | Issue 9/2011

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Abstract

Background

Ileal transposition (IT) can effectively resolve obesity and improve type 2 diabetes. IT is associated with increased glucagon-like peptide 1 secretion. The mechanisms mediating the effects of IT on obesity and diabetes remain undefined. Given the role of pro-opiomelanocortin neurons in energy balance, we sought to determine its potential role in these processes.

Methods

Twenty non-obese diabetic Goto–Kakizaki rats underwent either IT or sham operation. Various measures including food intake, body weight, fasting plasma glucose, glucagon-like peptide 1 level, activated pro-opiomelanocortin neuron number, and pro-opiomelanocortin mRNA expression were evaluated.

Results

The IT group demonstrated significantly improved plasma glucose homeostasis with increased glucagon-like peptide 1 secretion. The IT group ate less and demonstrated reduced body weight gain over time. These effects were also associated with increased central neuronal activity with increased pro-opiomelanocortin and derivative gene expression in the hypothalamus and increased protein expression in the pituitary gland.

Conclusions

More pro-opiomelanocortin neurons in the hypothalamus of diabetes rats were activated after ileal transposition. These data suggest a potential important role for pro-opiomelanocortin neurons in the resolution of diabetes after IT.
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Metadata
Title
The Changes of Pro-opiomelanocortin Neurons in Type 2 Diabetes Mellitus Rats After Ileal Transposition: The Role of POMC Neurons
Authors
Weijie Chen
Zhibo Yan
Shaozhuang Liu
Guangyong Zhang
Dong Sun
Sanyuan Hu
Publication date
01-09-2011
Publisher
Springer-Verlag
Published in
Journal of Gastrointestinal Surgery / Issue 9/2011
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-011-1606-7

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