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Journal of Gastrointestinal Surgery

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01-04-2011 | Original Article

Inflammatory Myofibroblastic Tumor of the Small Bowel Mesentery: An Unusual Cause of Abdominal Pain and Uveitis

Authors: Audrey H. Choi, Olga L. Bohn, Timothy D. Beddow, Christopher R. McHenry

Published in: Journal of Gastrointestinal Surgery | Issue 4/2011

Abstract

Introduction

An inflammatory myofibroblastic tumor (IMT) of the small bowel mesentery with diffuse immunohistochemical staining for the anaplastic lymphoma kinase 1 gene is reported in a patient who presented with abdominal pain and uveitis.

Discussion

To our knowledge, only seven cases of IMT affecting the small bowel mesentery have previously been reported in the English literature. The association of IMT and uveitis is a rare phenomenon, previously reported in patients with IMT affecting the head and neck. Surgical resection of the IMT resulted in rapid resolution of the uveitis.

Conclusion

IMT should be considered in the differential diagnosis for a mesenteric mass.

Brunn, H., Two interesting benign lung tumors of contradictory histopathology. J Thorac Surg, 1939. 9: p. 119–131.

Diaz-Torne, C., et al., Inflammatory pseudotumor of the liver associated with rheumatoid arthritis. Arthritis Rheum, 2007. 57(6): p. 1102–6.PubMedCrossRef

McHenry, C.R., et al., Inflammatory pseudotumor of the spleen: a rare entity that may mimic hematopoietic malignancy. Am Surg, 1995. 61(12): p. 1067–71.PubMed

Chen, S.S., et al., Mesenteric inflammatory myofibroblastic tumors in an elder patient with early recurrence: a case report. World J Gastroenterol, 2007. 13(26): p. 3645–8.PubMed

Vaughan, K.G., et al., Mesenteric inflammatory pseudotumor as a cause of abdominal pain in a teenager: presentation and literature review. Pediatr Surg Int, 2005. 21(6): p. 497–9.PubMedCrossRef

Cho, A.H., et al., Inflammatory pseudotumor of temporal bone with pachymeningitis, cranial neuropathies and uveitis. Eur Neurol, 2004. 51(4): p. 238–40.PubMedCrossRef

Uy, H.S., et al., Sclerosing inflammatory pseudotumor of the eye. Arch Ophthalmol, 2001. 119(4): p. 603–7.PubMed

Burke, A., et al., Cardiac inflammatory myofibroblastic tumor: a “benign” neoplasm that may result in syncope, myocardial infarction, and sudden death. Am J Surg Pathol, 2007. 31(7): p. 1115–22.PubMedCrossRef

Koirala, R., et al., Retroperitoneal inflammatory myofibroblastic tumor. Am J Surg, 2010. 199(2): p. e17–9.PubMedCrossRef

10.

Gleason, B.C. and J.L. Hornick, Inflammatory myofibroblastic tumours: where are we now? J Clin Pathol, 2008. 61(4): p. 428–37.PubMedCrossRef

11.

Pulford, K., et al., Immune response to the ALK oncogenic tyrosine kinase in patients with anaplastic large-cell lymphoma. Blood, 2000. 96(4): p. 1605–7.PubMed

12.

Vaglio, A., C. Salvarani, and C. Buzio, Retroperitoneal fibrosis. Lancet, 2006. 367(9506): p. 241–51.PubMedCrossRef

13.

Kutluk, T., et al., Mesenteric inflammatory pseudotumor: unusual presentation with leukemoid reaction and massive calcified mass. J Pediatr Hematol Oncol, 2002. 24(2): p. 158–9.PubMedCrossRef

14.

Miyazaki, H., et al., Inflammatory pseudotumor of the mesentery causing portal venous thrombosis and cavernomatous transformation. Intern Med, 2002. 41(8): p. 633–7.PubMedCrossRef

15.

Sawant, S., L. Kasturi, and A. Amin, Inflammatory myofibroblastic tumor. Indian J Pediatr, 2002. 69(11): p. 1001–2.PubMedCrossRef

16.

Treissman, S.P., et al., Omental-mesenteric inflammatory pseudotumor. Cytogenetic demonstration of genetic changes and monoclonality in one tumor. Cancer, 1994. 73(5): p. 1433–7.PubMedCrossRef

17.

Uysal, S., et al., Inflammatory pseudotumor of the sigmoid colon mesentery: US and CT findings (2004:12b). Eur Radiol, 2005. 15(3): p. 633–5.PubMedCrossRef

18.

Coffin, C.M., et al., Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol, 1995. 19(8): p. 859–72.PubMedCrossRef

19.

Fletcher, C.D., Unni, K.K., Mertens, F. (eds), Pathology and Genetics of Tumors of Soft Tissue and Bone. World Health Organization Classification of Tumours. 2002, Lyon: IARC Press. 91–93.

20.

Arber, D.A., et al., Frequent presence of the Epstein-Barr virus in inflammatory pseudotumor. Hum Pathol, 1995. 26(10): p. 1093–8.PubMedCrossRef

21.

Evans, J., et al., Inflammatory pseudotumour secondary to actinomyces infection. Aust N Z J Surg, 1999. 69(6): p. 467–9.PubMedCrossRef

22.

Rathinam, S., et al., Inflammatory myofibroblastic tumour at the pacemaker site. Interact Cardiovasc Thorac Surg, 2010. 10(3): p. 443–5.PubMedCrossRef

23.

Manganelli, P., et al., Clinical and histological coexistence of inflammatory pseudotumour of the lymph nodes and rheumatoid arthritis. Clin Rheumatol, 2003. 22(6): p. 467–71.PubMedCrossRef

24.

Hoene, K.A., et al., Inflammatory myofibroblastic tumor of the urinary bladder in a 27-year-old woman with systemic lupus erythematosus. Int J Urol, 2008. 15(2): p. 182–4.PubMedCrossRef

25.

Chang, Y., et al., Inflammatory pseudotumor of the choroid plexus in Sjogren’s disease. Neurosurgery, 1991. 29(2): p. 287–90.PubMedCrossRef

26.

Cush, J.J., I.H. Leibowitz, and S.A. Friedman, Adult-onset Still’s disease and inflammatory orbital pseudotumor. N Y State J Med, 1985. 85(3): p. 110–1.PubMed

27.

Coffin, C.M., J.L. Hornick, and C.D. Fletcher, Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases. Am J Surg Pathol, 2007. 31(4): p. 509–20.PubMedCrossRef

28.

Jiang, Y.H., et al., Comparison of the clinical and immunohistochemical features, including anaplastic lymphoma kinase (ALK) and p53, in inflammatory myofibroblastic tumours. J Int Med Res, 2009. 37(3): p. 867–77.PubMed

29.

Meis, J.M. and F.M. Enzinger, Inflammatory fibrosarcoma of the mesentery and retroperitoneum. A tumor closely simulating inflammatory pseudotumor. Am J Surg Pathol, 1991. 15(12): p. 1146–56.PubMedCrossRef

30.

Chun, Y.S., et al., Pediatric inflammatory myofibroblastic tumor: anaplastic lymphoma kinase (ALK) expression and prognosis. Pediatr Blood Cancer, 2005. 45(6): p. 796–801.PubMedCrossRef

31.

Favini, F., et al., Inflammatory myofibroblastic tumor of the conjunctiva: response to chemotherapy with low-dose methotrexate and vinorelbine. Pediatr Blood Cancer, 2010. 54(3): p. 483–5.PubMedCrossRef

32.

Kovach, S.J., et al., Inflammatory myofibroblastic tumors. J Surg Oncol, 2006. 94(5): p. 385–91.PubMedCrossRef

33.

Butrynski, J.E., et al., Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor. N Engl J Med, 2010. 363(18): p. 1727–33.PubMedCrossRef

34.

Dagash, H., et al., Inflammatory myofibroblastic tumor of the pancreas: a case report of 2 pediatric cases--steroids or surgery? J Pediatr Surg, 2009. 44(9): p. 1839–41.PubMedCrossRef

35.

Li, J.Y., et al., Bilateral renal inflammatory pseudotumour effectively treated with corticosteroid. Clin Exp Nephrol, 2010. 14(2): p. 190–8.PubMedCrossRef

36.

Hoover, S.V., et al., Plasma cell granuloma of the lung, response to radiation therapy: report of a single case. Cancer, 1977. 39(1): p. 123–5.PubMedCrossRef

37.

Imperato, J.P., et al., Treatment of plasma cell granuloma of the lung with radiation therapy. A report of two cases and a review of the literature. Cancer, 1986. 57(11): p. 2127–9.PubMedCrossRef

38.

Yu, D.C., et al., Primary lung tumors in children and adolescents: a 90-year experience. J Pediatr Surg, 2010. 45(6): p. 1090–5.PubMedCrossRef

Title: Inflammatory Myofibroblastic Tumor of the Small Bowel Mesentery: An Unusual Cause of Abdominal Pain and Uveitis
Authors: Audrey H. Choi
Olga L. Bohn
Timothy D. Beddow
Christopher R. McHenry
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 4/2011
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-010-1408-3

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Inflammatory Myofibroblastic Tumor of the Small Bowel Mesentery: An Unusual Cause of Abdominal Pain and Uveitis

Abstract

Introduction

Discussion

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Introduction

Discussion

Conclusion

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