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01-01-2011 | Original Article

Neuroendocrine Tumors of Meckel’s Diverticulum: Lessons from a Single Institution Study of Eight Cases

Authors: Gilles Poncet, MD, Valérie Hervieu, MD, Thomas Walter, MD, Florian Lépinasse, BSc, Laurence Chardon, MD, Frank Pilleul, MD, Catherine Lombard-Bohas, MD, Jean-Alain Chayvialle, MD, Christian Partensky, MD, Jean-Yves Scoazec, MD

Published in: Journal of Gastrointestinal Surgery | Issue 1/2011

Abstract

Introduction

Endocrine tumors of Meckel’s diverticulum are rare. Their clinical and pathological characteristics are not well known, making it difficult to assess the best strategy for therapeutic management.

Materials and Methods

Eight cases of endocrine tumors of Meckel’s diverticulum, submitted to surgical resection in our institution between 1977 and 2009, were studied. Clinical charts were reviewed; classification, grading, and staging were performed according to recent international recommendations. Five cases, including two associated with the carcinoid syndrome, were revealed by mesenteric mass or liver metastases; three cases were diagnosed incidentally at laparotomy or laparoscopy.

Results

All cases presented as typical well-differentiated midgut endocrine tumors. Five cases were associated with mesenteric lymph node metastases; three presented with liver metastases. Seven cases were classified as well-differentiated endocrine carcinomas, one as well-differentiated endocrine tumor of benign behavior.

Discussion

All tumors >1 cm, but one, had regional or distant disease. All patients had complete surgical resection of the primary. One patient deceased after 25 months; the others were alive after 12–101 months.

Conclusion

In conclusion, endocrine tumors of Meckel’s diverticulum are rarely symptomatic and often diagnosed at an advanced stage. All tumors measuring more than 1 cm in diameter must be resected according to oncological principles.

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Title: Neuroendocrine Tumors of Meckel’s Diverticulum: Lessons from a Single Institution Study of Eight Cases
Authors: Gilles Poncet, MD
Valérie Hervieu, MD
Thomas Walter, MD
Florian Lépinasse, BSc
Laurence Chardon, MD
Frank Pilleul, MD
Catherine Lombard-Bohas, MD
Jean-Alain Chayvialle, MD
Christian Partensky, MD
Jean-Yves Scoazec, MD
Publication date: 01-01-2011
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 1/2011
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-010-1312-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Neuroendocrine Tumors of Meckel’s Diverticulum: Lessons from a Single Institution Study of Eight Cases

Abstract

Introduction

Materials and Methods

Results

Discussion

Conclusion

At a glance: The ONWARDS insulin icodec trials

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Abstract

Introduction

Materials and Methods

Results

Discussion

Conclusion

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