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Journal of Gastrointestinal Surgery
Published in: Journal of Gastrointestinal Surgery 12/2009

01-12-2009 | 2009 SSAT Poster Presentation

A Matched Case-Control Study of Preoperative Biliary Drainage in Patients with Pancreatic Adenocarcinoma: Routine Drainage Is Not Justified

Authors: James J. Mezhir, Murray F. Brennan, Raymond E. Baser, Michael I. D’Angelica, Yuman Fong, Ronald P. DeMatteo, William R. Jarnagin, Peter J. Allen

Published in: Journal of Gastrointestinal Surgery | Issue 12/2009

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Abstract

Background

Preoperative biliary drainage (PBD) prior to pancreaticoduodenectomy (PD) continues to be routine in many centers despite retrospective and randomized data showing that PBD increases perioperative infectious complications.

Methods

Review of a prospectively maintained database identified 340 consecutive patients with pancreatic adenocarcinoma who underwent PD between 2000 and 2005. From this cohort, 94 PBD and 94 nonstented (no-PBD) patients were matched for age, gender, preoperative albumin, and bilirubin levels (PBD group: prestent bilirubin; no-PBD group: preoperative bilirubin).

Results

The majority of PBD patients (89%) underwent internal endoscopic biliary drainage. Stent-related complications occurred in 46 patients (23%) and resulted in a significant delay in time to resection. In the matched-pair comparison, there was more operative blood loss in PBD patients, but similar operative times, transfusions, and hospital stay. Bile cultures were positive in 82% of PBD patients versus 7% no PBD. There was a statistically significant increase in infectious complications including wound infections and intra-abdominal abscess in PBD patients, but equal incidence of anastomotic leak.

Conclusions

In this case-matched control study, PBD was associated with a stent-related complication rate of 23% and resulted in a twofold increase in postpancreatectomy infectious complications. The routine use of PBD remains unjustified.
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Metadata
Title
A Matched Case-Control Study of Preoperative Biliary Drainage in Patients with Pancreatic Adenocarcinoma: Routine Drainage Is Not Justified
Authors
James J. Mezhir
Murray F. Brennan
Raymond E. Baser
Michael I. D’Angelica
Yuman Fong
Ronald P. DeMatteo
William R. Jarnagin
Peter J. Allen
Publication date
01-12-2009
Publisher
Springer-Verlag
Published in
Journal of Gastrointestinal Surgery / Issue 12/2009
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-009-1046-9

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