Skip to main content
Top
Published in: Journal of Gastrointestinal Surgery 2/2008

01-02-2008 | ahpba annual meeting

Right Portal Vein Ligation is as Efficient as Portal Vein Embolization to Induce Hypertrophy of the Left Liver Remnant

Authors: B. Aussilhou, M. Lesurtel, A. Sauvanet, O. Farges, S. Dokmak, N. Goasguen, A. Sibert, V. Vilgrain, J. Belghiti

Published in: Journal of Gastrointestinal Surgery | Issue 2/2008

Login to get access

Abstract

Background

Aim of this retrospective study was to compare induction of left liver hypertrophy after right portal vein ligation (PVL) and right portal vein embolization (PVE) before right hepatectomy for liver metastases.

Materials and Methods

Between 1998 and 2005, 18 patients underwent a PVE, whereas 17 patients underwent a PVL during a first stage laparotomy.

Results

There was no complication related to PVE or PVL. After a similar interval time (7 ± 3 vs 8 ± 3 weeks), the increase of the left liver volume was similar between the two groups (35 ± 38 vs 38 ± 26%). After PVE and PVL, right hepatectomy was performed in 12 and 14 patients, respectively. Technical difficulties during the right hepatectomy were similar according to duration of procedure (6.4 ± 1 vs 6.7 ± 1 h, p = 0.7) and transfusion rates (33 vs 28%, p = 0.7). Mortality was nil in both groups, and morbidity rates were respectively 58% for the PVE group and 36% for the PVL group (p = 0.6).

Conclusion

Right PVL and PVE result in a comparable hypertrophy of the left liver. During the first laparotomy of a two-step liver resection, PVL can be efficiently and safely performed.
Literature
1.
go back to reference Imamura H, Seyama Y, Kokudo N, Aoki T, Sano K, Minagawa M, Sugawara Y, Makuuchi M. Single and multiple resections of multiple hepatic metastases of colorectal origin. Surgery 2004;135(5):508–517.PubMedCrossRef Imamura H, Seyama Y, Kokudo N, Aoki T, Sano K, Minagawa M, Sugawara Y, Makuuchi M. Single and multiple resections of multiple hepatic metastases of colorectal origin. Surgery 2004;135(5):508–517.PubMedCrossRef
2.
go back to reference Jarnagin WR, Gonen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, Corvera C, Weber S, Blumgart LH. Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Ann Surg 2002;236(4):397–406.PubMedCrossRef Jarnagin WR, Gonen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, Corvera C, Weber S, Blumgart LH. Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Ann Surg 2002;236(4):397–406.PubMedCrossRef
3.
go back to reference Kubota K, Makuuchi M, Kusaka K, Kobayashi T, Miki K, Hasegawa K, Harihara Y, Takayama T. Measurement of liver volume and hepatic functional reserve as a guide to decision-making in resectional surgery for hepatic tumors. Hepatology 1997;26(5):1176–1181.PubMed Kubota K, Makuuchi M, Kusaka K, Kobayashi T, Miki K, Hasegawa K, Harihara Y, Takayama T. Measurement of liver volume and hepatic functional reserve as a guide to decision-making in resectional surgery for hepatic tumors. Hepatology 1997;26(5):1176–1181.PubMed
4.
go back to reference Azoulay D, Castaing D, Smail A, Adam R, Cailliez V, Laurent A, Lemoine A, Bismuth H. Resection of nonresectable liver metastases from colorectal cancer after percutaneous portal vein embolization. Ann Surg 2000;231(4):480–486.PubMedCrossRef Azoulay D, Castaing D, Smail A, Adam R, Cailliez V, Laurent A, Lemoine A, Bismuth H. Resection of nonresectable liver metastases from colorectal cancer after percutaneous portal vein embolization. Ann Surg 2000;231(4):480–486.PubMedCrossRef
5.
go back to reference Adam R, Delvart V, Pascal G, Valeanu A, Castaing D, Azoulay D, Giacchetti S, Paule B, Kunstlinger F, Ghemard O, Levi F, Bismuth H. Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival. Ann Surg 2004;240(4):644–657.PubMed Adam R, Delvart V, Pascal G, Valeanu A, Castaing D, Azoulay D, Giacchetti S, Paule B, Kunstlinger F, Ghemard O, Levi F, Bismuth H. Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival. Ann Surg 2004;240(4):644–657.PubMed
6.
go back to reference Allen PJ, Kemeny N, Jarnagin W, DeMatteo R, Blumgart L, Fong Y. Importance of response to neoadjuvant chemotherapy in patients undergoing resection of synchronous colorectal liver metastases. J Gastrointest Surg 2003;7(1):109–115.PubMedCrossRef Allen PJ, Kemeny N, Jarnagin W, DeMatteo R, Blumgart L, Fong Y. Importance of response to neoadjuvant chemotherapy in patients undergoing resection of synchronous colorectal liver metastases. J Gastrointest Surg 2003;7(1):109–115.PubMedCrossRef
7.
go back to reference Adam R, Pascal G, Castaing D, Azoulay D, Delvart V, Paule B, Levi F, Bismuth H. Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases? Ann Surg 2004;240(6):1052–1061.PubMedCrossRef Adam R, Pascal G, Castaing D, Azoulay D, Delvart V, Paule B, Levi F, Bismuth H. Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases? Ann Surg 2004;240(6):1052–1061.PubMedCrossRef
8.
go back to reference Aloia T, Sebagh M, Plasse M, Karam V, Levi F, Giacchetti S, Azoulay D, Bismuth H, Castaing D, Adam R. Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases. J Clin Oncol 2006;24(31):4983–4990.PubMedCrossRef Aloia T, Sebagh M, Plasse M, Karam V, Levi F, Giacchetti S, Azoulay D, Bismuth H, Castaing D, Adam R. Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases. J Clin Oncol 2006;24(31):4983–4990.PubMedCrossRef
9.
go back to reference Vauthey JN, Pawlik TM, Ribero D, Wu TT, Zorzi D, Hoff PM, Xiong HQ, Eng C, Lauwers GY, Mino-Kenudson M, Risio M, Muratore A, Capussotti L, Curley SA, Abdalla EK. Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol 2006;24(13):2065–2072.PubMedCrossRef Vauthey JN, Pawlik TM, Ribero D, Wu TT, Zorzi D, Hoff PM, Xiong HQ, Eng C, Lauwers GY, Mino-Kenudson M, Risio M, Muratore A, Capussotti L, Curley SA, Abdalla EK. Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol 2006;24(13):2065–2072.PubMedCrossRef
10.
go back to reference Kianmanesh R, Farges O, Abdalla EK, Sauvanet A, Ruszniewski P, Belghiti J. Right portal vein ligation: a new planned two-step all-surgical approach for complete resection of primary gastrointestinal tumors with multiple bilateral liver metastases. J Am Coll Surg 2003;197(1):164–170.PubMedCrossRef Kianmanesh R, Farges O, Abdalla EK, Sauvanet A, Ruszniewski P, Belghiti J. Right portal vein ligation: a new planned two-step all-surgical approach for complete resection of primary gastrointestinal tumors with multiple bilateral liver metastases. J Am Coll Surg 2003;197(1):164–170.PubMedCrossRef
11.
go back to reference Jaeck D, Oussoultzoglou E, Rosso E, Greget M, Weber JC, Bachellier P. A two-stage hepatectomy procedure combined with portal vein embolization to achieve curative resection for initially unresectable multiple and bilobar colorectal liver metastases. Ann Surg 2004;240(6):1037–1049.PubMedCrossRef Jaeck D, Oussoultzoglou E, Rosso E, Greget M, Weber JC, Bachellier P. A two-stage hepatectomy procedure combined with portal vein embolization to achieve curative resection for initially unresectable multiple and bilobar colorectal liver metastases. Ann Surg 2004;240(6):1037–1049.PubMedCrossRef
12.
go back to reference Takayasu K, Muramatsu Y, Shima Y, Moriyama N, Yamada T, Makuuchi M. Hepatic lobar atrophy following obstruction of the ipsilateral portal vein from hilar cholangiocarcinoma. Radiology 1986;160(2):389–393.PubMed Takayasu K, Muramatsu Y, Shima Y, Moriyama N, Yamada T, Makuuchi M. Hepatic lobar atrophy following obstruction of the ipsilateral portal vein from hilar cholangiocarcinoma. Radiology 1986;160(2):389–393.PubMed
13.
go back to reference Adam R, Laurent A, Azoulay D, Castaing D, Bismuth H. Two-stage hepatectomy: a planned strategy to treat irresectable liver tumors. Ann Surg 2000;232(6):777–785.PubMedCrossRef Adam R, Laurent A, Azoulay D, Castaing D, Bismuth H. Two-stage hepatectomy: a planned strategy to treat irresectable liver tumors. Ann Surg 2000;232(6):777–785.PubMedCrossRef
14.
go back to reference Denys AL, Abehsera M, Sauvanet A, Sibert A, Belghiti J, Menu Y. Failure of right portal vein ligation to induce left lobe hypertrophy due to intrahepatic portoportal collaterals: successful treatment with portal vein embolization. AJR Am J Roentgenol 1999;173(3):633–635.PubMed Denys AL, Abehsera M, Sauvanet A, Sibert A, Belghiti J, Menu Y. Failure of right portal vein ligation to induce left lobe hypertrophy due to intrahepatic portoportal collaterals: successful treatment with portal vein embolization. AJR Am J Roentgenol 1999;173(3):633–635.PubMed
15.
go back to reference Broering DC, Hillert C, Krupski G, Fischer L, Mueller L, Achilles EG, Schulte am Esch J, Rogiers X. Portal vein embolization vs. portal vein ligation for induction of hypertrophy of the future liver remnant. J Gastrointest Surg 2002;6(6):905–193.PubMedCrossRef Broering DC, Hillert C, Krupski G, Fischer L, Mueller L, Achilles EG, Schulte am Esch J, Rogiers X. Portal vein embolization vs. portal vein ligation for induction of hypertrophy of the future liver remnant. J Gastrointest Surg 2002;6(6):905–193.PubMedCrossRef
16.
go back to reference Farges O, Belghiti J, Kianmanesh R, Regimbeau JM, Santoro R, Vilgrain V, Denys A, Sauvanet A. Portal vein embolization before right hepatectomy: prospective clinical trial. Ann Surg 2003;237(2):208–217.PubMedCrossRef Farges O, Belghiti J, Kianmanesh R, Regimbeau JM, Santoro R, Vilgrain V, Denys A, Sauvanet A. Portal vein embolization before right hepatectomy: prospective clinical trial. Ann Surg 2003;237(2):208–217.PubMedCrossRef
17.
go back to reference Balzan S, Belghiti J, Farges O, Ogata S, Sauvanet A, Delefosse D, Durand F. The “50–50 criteria” on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy. Ann Surg 2005;242(6):824–828.PubMedCrossRef Balzan S, Belghiti J, Farges O, Ogata S, Sauvanet A, Delefosse D, Durand F. The “50–50 criteria” on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy. Ann Surg 2005;242(6):824–828.PubMedCrossRef
18.
go back to reference Harada H, Imamura H, Miyagawa S, Kawasaki S. Fate of the human liver after hemihepatic portal vein embolization: cell kinetic and morphometric study. Hepatology 1997;26(5):1162–1170.PubMed Harada H, Imamura H, Miyagawa S, Kawasaki S. Fate of the human liver after hemihepatic portal vein embolization: cell kinetic and morphometric study. Hepatology 1997;26(5):1162–1170.PubMed
19.
go back to reference Fujii Y, Shimada H, Endo I, Kamiyama M, Kamimukai N, Tanaka K, Kunisaki C, Sekido H, Togo S, Nagashima Y. Changes in clinicopathological findings after portal vein embolization. Hepatogastroenterology 2000;47(36):1560–1563.PubMed Fujii Y, Shimada H, Endo I, Kamiyama M, Kamimukai N, Tanaka K, Kunisaki C, Sekido H, Togo S, Nagashima Y. Changes in clinicopathological findings after portal vein embolization. Hepatogastroenterology 2000;47(36):1560–1563.PubMed
20.
go back to reference Komori K, Nagino M, Nimura Y. Hepatocyte morphology and kinetics after portal vein embolization. Br J Surg 2006;93(6):745–751.PubMedCrossRef Komori K, Nagino M, Nimura Y. Hepatocyte morphology and kinetics after portal vein embolization. Br J Surg 2006;93(6):745–751.PubMedCrossRef
21.
go back to reference Starzl TE, Francavilla A, Halgrimson CG, Francavilla FR, Porter KA, Brown TH, Putnam CW. The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood. Surg Gynecol Obstet 1973;137(2):179–199.PubMed Starzl TE, Francavilla A, Halgrimson CG, Francavilla FR, Porter KA, Brown TH, Putnam CW. The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood. Surg Gynecol Obstet 1973;137(2):179–199.PubMed
22.
go back to reference Abdalla EK, Hicks ME, Vauthey JN. Portal vein embolization: rationale, technique and future prospects. Br J Surg 2001;88(2):165–175.PubMedCrossRef Abdalla EK, Hicks ME, Vauthey JN. Portal vein embolization: rationale, technique and future prospects. Br J Surg 2001;88(2):165–175.PubMedCrossRef
23.
go back to reference Bouzari H, Amisano M, Zorzi D, Vigano L, Capussotti L, Muratore A. Hypertrophy of the future liver remnant volume following portal vein occlusion: portal vein embolization vs portal vein ligation. HPB 2006;8(S2):27–28. Bouzari H, Amisano M, Zorzi D, Vigano L, Capussotti L, Muratore A. Hypertrophy of the future liver remnant volume following portal vein occlusion: portal vein embolization vs portal vein ligation. HPB 2006;8(S2):27–28.
24.
go back to reference Krupski G, Broring DC, Wittkugel O, Muller L, Nicolas V, Rogiers X, Adam G, Bucheler E. Formation of portal venous collaterals after ligation of the portal vein for induction of liver regeneration. Rofo 2002;174(10):1281–1284.PubMed Krupski G, Broring DC, Wittkugel O, Muller L, Nicolas V, Rogiers X, Adam G, Bucheler E. Formation of portal venous collaterals after ligation of the portal vein for induction of liver regeneration. Rofo 2002;174(10):1281–1284.PubMed
25.
go back to reference Goto Y, Nagino M, Nimura Y. Doppler estimation of portal blood flow after percutaneous transhepatic portal vein embolization. Ann Surg 1998;228(2):209–213.PubMedCrossRef Goto Y, Nagino M, Nimura Y. Doppler estimation of portal blood flow after percutaneous transhepatic portal vein embolization. Ann Surg 1998;228(2):209–213.PubMedCrossRef
26.
go back to reference Yachida S, Ikeda K, Kaneda K, Goda F, Maeba T, Maeta H. Preventive effect of preoperative portal vein ligation on endotoxin-induced hepatic failure in hepatectomized rats is associated with reduced tumour necrosis factor alpha production. Br J Surg 2000;87(10):1382–1390.PubMedCrossRef Yachida S, Ikeda K, Kaneda K, Goda F, Maeba T, Maeta H. Preventive effect of preoperative portal vein ligation on endotoxin-induced hepatic failure in hepatectomized rats is associated with reduced tumour necrosis factor alpha production. Br J Surg 2000;87(10):1382–1390.PubMedCrossRef
27.
go back to reference Heinrich S, Jochum W, Graf R, Clavien PA. Portal vein ligation and partial hepatectomy differentially influence growth of intrahepatic metastasis and liver regeneration in mice. J Hepatol 2006;45(1):35–42.PubMedCrossRef Heinrich S, Jochum W, Graf R, Clavien PA. Portal vein ligation and partial hepatectomy differentially influence growth of intrahepatic metastasis and liver regeneration in mice. J Hepatol 2006;45(1):35–42.PubMedCrossRef
28.
go back to reference Dagher I, Lainas P, Boudechiche L, Coulomb-Lhermine A, Weber A, Osorio A, Pariente D, Franco D. Reversible portal vein embolization induces efficient liver regeneration. Ann Chir 2006;131(10):665. Dagher I, Lainas P, Boudechiche L, Coulomb-Lhermine A, Weber A, Osorio A, Pariente D, Franco D. Reversible portal vein embolization induces efficient liver regeneration. Ann Chir 2006;131(10):665.
29.
go back to reference Belghiti J, Hiramatsu K, Benoist S, Massault P, Sauvanet A, Farges O. Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection. J Am Coll Surg 2000;191(1):38–46.PubMedCrossRef Belghiti J, Hiramatsu K, Benoist S, Massault P, Sauvanet A, Farges O. Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection. J Am Coll Surg 2000;191(1):38–46.PubMedCrossRef
30.
go back to reference Imamura H, Seyama Y, Kokudo N, Maema A, Sugawara Y, Sano K, Takayama T, Makuuchi M. One thousand fifty-six hepatecto-mies without mortality in 8 years. Arch Surg 2003;138(11):1198–206.PubMedCrossRef Imamura H, Seyama Y, Kokudo N, Maema A, Sugawara Y, Sano K, Takayama T, Makuuchi M. One thousand fifty-six hepatecto-mies without mortality in 8 years. Arch Surg 2003;138(11):1198–206.PubMedCrossRef
31.
go back to reference Elias D, De Baere T, Roche A, Ducreux M, Leclere J, Lasser P. During liver regeneration following right portal embolization the growth rate of liver metastases is more rapid than that of the liver parenchyma. Br J Surg 1999;86(6):784–788.PubMedCrossRef Elias D, De Baere T, Roche A, Ducreux M, Leclere J, Lasser P. During liver regeneration following right portal embolization the growth rate of liver metastases is more rapid than that of the liver parenchyma. Br J Surg 1999;86(6):784–788.PubMedCrossRef
32.
go back to reference Kokudo N, Tada K, Seki M, Ohta H, Azekura K, Ueno M, Ohta K, Yamaguchi T, Matsubara T, Takahashi T, Nakajima T, Muto T, Ikari T, Yanagisawa A, Kato Y. Proliferative activity of intrahepatic colorectal metastases after preoperative hemihepatic portal vein embolization. Hepatology 2001;34(2):267–272.PubMedCrossRef Kokudo N, Tada K, Seki M, Ohta H, Azekura K, Ueno M, Ohta K, Yamaguchi T, Matsubara T, Takahashi T, Nakajima T, Muto T, Ikari T, Yanagisawa A, Kato Y. Proliferative activity of intrahepatic colorectal metastases after preoperative hemihepatic portal vein embolization. Hepatology 2001;34(2):267–272.PubMedCrossRef
33.
go back to reference Abdalla EK, Adam R, Bilchik AJ, Jaeck D, Vauthey JN, Mahvi D. Improving resectability of hepatic colorectal metastases: expert consensus statement. Ann Surg Oncol 2006;13(10):1271–1280.PubMedCrossRef Abdalla EK, Adam R, Bilchik AJ, Jaeck D, Vauthey JN, Mahvi D. Improving resectability of hepatic colorectal metastases: expert consensus statement. Ann Surg Oncol 2006;13(10):1271–1280.PubMedCrossRef
34.
go back to reference Karoui M, Penna C, Amin-Hashem M, Mitry E, Benoist S, Franc B, Rougier P, Nordlinger B. Influence of preoperative chemotherapy on the risk of major hepatectomy for colorectal liver metastases. Ann Surg 2006;243(1):1–7.PubMedCrossRef Karoui M, Penna C, Amin-Hashem M, Mitry E, Benoist S, Franc B, Rougier P, Nordlinger B. Influence of preoperative chemotherapy on the risk of major hepatectomy for colorectal liver metastases. Ann Surg 2006;243(1):1–7.PubMedCrossRef
35.
go back to reference Goere D, Farges O, Leporrier J, Sauvanet A, Vilgrain V, Belghiti J. Chemotherapy does not impair hypertrophy of the left liver after right portal vein obstruction. J Gastrointest Surg 2006;10(3):365–370.PubMedCrossRef Goere D, Farges O, Leporrier J, Sauvanet A, Vilgrain V, Belghiti J. Chemotherapy does not impair hypertrophy of the left liver after right portal vein obstruction. J Gastrointest Surg 2006;10(3):365–370.PubMedCrossRef
Metadata
Title
Right Portal Vein Ligation is as Efficient as Portal Vein Embolization to Induce Hypertrophy of the Left Liver Remnant
Authors
B. Aussilhou
M. Lesurtel
A. Sauvanet
O. Farges
S. Dokmak
N. Goasguen
A. Sibert
V. Vilgrain
J. Belghiti
Publication date
01-02-2008
Publisher
Springer-Verlag
Published in
Journal of Gastrointestinal Surgery / Issue 2/2008
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-007-0410-x

Other articles of this Issue 2/2008

Journal of Gastrointestinal Surgery 2/2008 Go to the issue