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01-01-2008 | grassi prize finalist

Radiofrequency Ablation Versus Surgical Resection for the Treatment of Hepatocellular Carcinoma in Cirrhosis

Authors: Alfredo Guglielmi, Andrea Ruzzenente, Alessandro Valdegamberi, Silvia Pachera, Tommaso Campagnaro, Mirko D’Onofrio, Enrico Martone, Paola Nicoli, Calogero Iacono

Published in: Journal of Gastrointestinal Surgery | Issue 1/2008

Abstract

Background and Aims

Percutaneous radiofrequency ablation (RFA) demonstrated good results for the treatment of hepatocellular carcinoma (HCC) in cirrhotic patients; it is still not clear whether the overall survival and disease-free survival after RFA are comparable with surgical resection. The aims of this study are to compare the overall survival and disease-free survival in two groups of cirrhotic patients with HCC submitted to surgery or RFA.

Methods

Two hundred cirrhotic patients with HCCs smaller than 6 cm were included in this retrospective study: 109 underwent RFA and 91 underwent surgical resection at a single Division of Surgery of University of Verona.

Results

Median follow-up time was 27 months. Overall survival was significantly longer in the resection group in comparison with the RFA group with a median survival of 57 and 28 months, respectively (P = 0.01). In Child–Pugh class B patients and in patients with multiple HCC, survival was not significantly different between the two groups. In patients with HCC smaller than 3 cm, the overall survival and disease-free survival for RFA and resection were not significantly different in univariate and multivariate analysis. Whereas in patients with HCC greater than 3 cm, surgery showed improvement in outcome in both univariate and multivariate analysis.

Conclusions

Surgical resection significantly improves the overall survival and disease-free survival in comparison with RFA. In a selected group of patients (Child–Pugh class B, multiple HCC, or in HCC ≤3 cm), the results between the two treatments did not show significant differences.

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Title: Radiofrequency Ablation Versus Surgical Resection for the Treatment of Hepatocellular Carcinoma in Cirrhosis
Authors: Alfredo Guglielmi
Andrea Ruzzenente
Alessandro Valdegamberi
Silvia Pachera
Tommaso Campagnaro
Mirko D’Onofrio
Enrico Martone
Paola Nicoli
Calogero Iacono
Publication date: 01-01-2008
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 1/2008
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-007-0392-8

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Radiofrequency Ablation Versus Surgical Resection for the Treatment of Hepatocellular Carcinoma in Cirrhosis

Abstract

Background and Aims

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background and Aims

Methods

Results

Conclusions

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